2,6-difluoro-3,5-diMethoxybenzenaMine
- CAS No.
- 651734-54-2
- Chemical Name:
- 2,6-difluoro-3,5-diMethoxybenzenaMine
- Synonyms
- 2,6-Difluoro-3,5-dimethoxyaniline;PEMIGATINIB INT1;Pemetinib intermediate;Chlorpyrifos Impurity 8 (Profenofos);2,6-difluoro-3,5-diMethoxybenzenaMine;2,6-difluoro-3,5-dimethoxy-phenylamine;2,6-difluoro-3,5-dimethoxybenzeneamine;Benzenamine, 2,6-difluoro-3,5-dimethoxy-
- CBNumber:
- CB52702895
- Molecular Formula:
- C8H9F2NO2
- Molecular Weight:
- 189.16
- MDL Number:
- MFCD12973804
- MOL File:
- 651734-54-2.mol
| Product description | Number | Pack Size | Price |
| 2,6-Difluoro-3,5-dimethoxyaniline 99% | PC908567 | 250mg | $21 |
| 2,6-Difluoro-3,5-dimethoxyaniline 99% | PC908567 | 1g | $24 |
| 2,6-Difluoro-3,5-dimethoxyaniline 99% | PC908567 | 5g | $35 |
| 2,6-Difluoro-3,5-dimethoxyaniline 99% | PC908567 | 25g | $154 |
| 2,6-Difluoro-3,5-dimethoxyaniline 99% | PC908567 | 100g | $581 |
| Boiling point | 301.0±37.0 °C(Predicted) |
|---|---|
| Density | 1.276±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| pka | 0.97±0.10(Predicted) |
| Appearance | Light brown to brown Solid |
| InChI | InChI=1S/C8H9F2NO2/c1-12-4-3-5(13-2)7(10)8(11)6(4)9/h3H,11H2,1-2H3 |
| InChIKey | SUXITUVUFUOAGT-UHFFFAOYSA-N |
| SMILES | C1(N)=C(F)C(OC)=CC(OC)=C1F |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P301+P312-P302+P352-P304+P340-P305+P351+P338 |
| HS Code | 2922190090 |
2,6-difluoro-3,5-diMethoxybenzenaMine price More Price(31)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | PC908567 | 2,6-Difluoro-3,5-dimethoxyaniline 99% | 651734-54-2 | 250mg | $21 | 2026-06-04 | Buy |
| Apolloscientific | PC908567 | 2,6-Difluoro-3,5-dimethoxyaniline 99% | 651734-54-2 | 1g | $24 | 2026-06-04 | Buy |
| Apolloscientific | PC908567 | 2,6-Difluoro-3,5-dimethoxyaniline 99% | 651734-54-2 | 5g | $35 | 2026-06-04 | Buy |
| Apolloscientific | PC908567 | 2,6-Difluoro-3,5-dimethoxyaniline 99% | 651734-54-2 | 25g | $154 | 2026-06-04 | Buy |
| Apolloscientific | PC908567 | 2,6-Difluoro-3,5-dimethoxyaniline 99% | 651734-54-2 | 100g | $581 | 2026-06-04 | Buy |
2,6-difluoro-3,5-diMethoxybenzenaMine Chemical Properties,Uses,Production
Uses
2,6-Difluoro-3,5-dimethoxyaniline is an organic compound used primarily as an organic synthesis intermediate and a pharmaceutical intermediate, especially in laboratory research and development and chemical production processes. The compound is a key intermediate in the drug pemigatinib, used to treat certain types of cancer.
Synthesis
651734-57-5
651734-54-2
Tert-butyl 2,6-difluoro-3,5-dimethoxyphenylcarbamate (34.6 g, 0.12 mol) was added to 120 mL of trifluoroacetic acid and stirred until completely dissolved to form a homogeneous solution. The reaction mixture was stirred at room temperature for 30 minutes. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure. To the residue, saturated sodium bicarbonate solution was slowly added to adjust the pH to 8. The resulting suspension was extracted twice with diethyl ether (appropriate amount each time). The organic phases were combined, washed once with saturated saline, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give 22 g of 2,6-difluoro-3,5-dimethoxyaniline in 97% yield. The mass spectrum (APCI) showed (M+1)/z of 190.1.
References
[1] Patent: WO2006/38112, 2006, A1. Location in patent: Page/Page column 28
[2] Patent: US2004/19210, 2004, A1. Location in patent: Page 13
2,6-difluoro-3,5-diMethoxybenzenaMine Preparation Products And Raw materials
Raw materials
Preparation Products
2,6-difluoro-3,5-diMethoxybenzenaMine Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| .GZ HONESTCHEM CO.,LTD | +86-15013270415 | honestchemical@foxmail.com | China | 297 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29626 | 60 |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 8491 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569262 +86-15003564040 | 1056@dideu.com | China | 3968 | 58 |
| Neostar United (Changzhou) Industrial Co., Ltd. | +86-0519-85551759 | marketing1@neostarunited.com | China | 8827 | 58 |
| Shanghai UCHEM Inc. | +86-18930848214 +86-021-56762820 | sales@myuchem.com | China | 8899 | 58 |
| CR Corporation Limited | fred.wen@crcorporation.cn | China | 8642 | 58 | |
| Labnetwork lnc. | +86-27-50766799 +86-18062016861 | contact@labnetwork.com | China | 19981 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418684 +86-18949823763 | sales@tnjchem.com | China | 25333 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 +8619957148339 | market18@leapchem.com | China | 24569 | 58 |
View Lastest Price from 2,6-difluoro-3,5-diMethoxybenzenaMine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-10 | 2,6-difluoro-3,5-dimethoxyaniline
651734-54-2
|
$1.00 | 300g | 99.8% | 20 TONS | .GZ HONESTCHEM CO.,LTD | |
 |
2024-11-26 | 2,6-Difluoro-3,5-dimethoxybenzenamine
651734-54-2
|
1kg | 98% | 1 ton | Nanjing Fred Technology Co., Ltd |
-
- 2,6-difluoro-3,5-dimethoxyaniline
651734-54-2
- $1.00
- 99.8%
- .GZ HONESTCHEM CO.,LTD
-
- 2,6-Difluoro-3,5-dimethoxybenzenamine
651734-54-2
- 98%
- Nanjing Fred Technology Co., Ltd
