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ChemicalBook >> CAS DataBase List >>BETA-POMPILIDOTOXIN

BETA-POMPILIDOTOXIN

CAS No.
216064-36-7
Chemical Name:
BETA-POMPILIDOTOXIN
Synonyms
β-PMTX;BETA-PMTX;POMPILIDOTOXIN;β-Pompilidotoxin;b-Pompilidotoxin;RIKIGLFDQLSRL-NH2;BETA-POMPILIDOTOXIN;L-Leucinamide, L-arginyl-L-isoleucyl-L-lysyl-L-isoleucylglycyl-L-leucyl-L-phenylalanyl-L-α-aspartyl-L-glutaminyl-L-leucyl-L-seryl-L-arginyl-
CBNumber:
CB5324309
Molecular Formula:
C71H124N22O17
Molecular Weight:
1557.88
MDL Number:
MFCD03788007
MOL File:
216064-36-7.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-04-24 14:59:12
Product description Number Pack Size Price
β-Pompilidotoxin CS-0027628 1mg $54
β-Pompilidotoxin CS-0027628 5mg $130
β-Pompilidotoxin CS-0027628 10mg $195
β-Pompilidotoxin CS-0027628 1mg $54
β-Pompilidotoxin CS-0027628 5mg $130

BETA-POMPILIDOTOXIN Properties

storage temp. −20°C
solubility ≥155.8 mg/mL in DMSO; insoluble in EtOH; ≥22.05 mg/mL in H2O
form solid
color White to off-white
Water Solubility Soluble to 1 mg/ml in water
Sequence Arg-Ile-Lys-Ile-Gly-Leu-Phe-Asp-Gln-Leu-Ser-Arg-Leu-NH2

SAFETY

Risk and Safety Statements

WGK Germany  3

BETA-POMPILIDOTOXIN price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-0027628 β-Pompilidotoxin 216064-36-7 1mg $54 2026-06-04 Buy
ChemScene CS-0027628 β-Pompilidotoxin 216064-36-7 5mg $130 2026-06-04 Buy
ChemScene CS-0027628 β-Pompilidotoxin 216064-36-7 10mg $195 2026-06-04 Buy
ChemScene CS-0027628 β-Pompilidotoxin 216064-36-7 1mg $54 2026-06-04 Buy
ChemScene CS-0027628 β-Pompilidotoxin 216064-36-7 5mg $130 2026-06-04 Buy
Product number Packaging Price Buy
CS-0027628 1mg $54 Buy
CS-0027628 5mg $130 Buy
CS-0027628 10mg $195 Buy
CS-0027628 1mg $54 Buy
CS-0027628 5mg $130 Buy

BETA-POMPILIDOTOXIN Chemical Properties,Uses,Production

Uses

β-Pompilidotoxin (β-PMTX), a wasp venom, can slow sodium channel inactivation and increases steady-state sodium current in cells[1].

Biological Activity

β-pompilidotoxin, (c71h124n22o17), a peptide with the sequence h2n-arg-ile-lys-ile-gly-leu-phe-asp-gln-leu-ser-arg-leu-amide, mw= 1557.88. pompilidotoxin is a toxin from the venom of spider wasps that slows the inactivation of na+channels. α-pompilidotoxin (α-pmtx) can be extracted from the venom of a solitary wasp, anopolis samariensis. β-pompilidotoxin (β-pmtx) originates from the venom of another wasp, batozonellus maculifrons(1). homology α-pmtx has no structural homology with other toxins. it lacks disulfide bonds which are known to be present in other toxins acting on sodium channels, such as sea anemone toxins or scorpion toxins(2). both α- and β-pmtx slow the inactivation of neuronal sodium channels (but not heart sodium channels), possibly by binding to the neurotoxin receptor site 3 on the extracellular surface of the sodium channel(3). β-pmtx has higher potency than α-pmtx. by slowing down the inactivation of sodium channels, pmtxs can potentiate synaptic transmission in the lobster neuromuscular endplate.figure1 formula of β-pompilidotoxin

References

1. Konno K, Hisada M, Itagaki Y, Naoki H, Kawai N, Miwa A, Yasuhara T, Takayama H (1998). "Isolation and structure of pompilidotoxins, novel peptide neurotoxins in solitary wasp venoms". Biochem Biophys Res Commun. 250 (3): 612–6.2. Sahara Y, Gotoh M, Konno K, Miwa A, Tsubokawa H, Robinson HP, Kawai N (2000). "A new class of neurotoxin from wasp venom slows inactivation of sodium current". Eur J Neurosci. 12 (6): 1961–70.3. Kawai N, Konno K (2004). "Molecular determinants of two neurotoxins that regulate sodium current inactivation in rat hippocampal neurons". Neurosci Lett. 361 (1-3): 44–6.

BETA-POMPILIDOTOXIN Preparation Products And Raw materials

Raw materials

Preparation Products

BETA-POMPILIDOTOXIN Suppliers

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MedBioPharmaceutical Technology Inc 021-69568360 18916172912 order@med-bio.cn China 8140 58

BETA-POMPILIDOTOXIN Spectrum

216064-36-7(BETA-POMPILIDOTOXIN)Related Search:

BETA-PMTX BETA-POMPILIDOTOXIN RIKIGLFDQLSRL-NH2 b-Pompilidotoxin β-PMTX β-Pompilidotoxin L-Leucinamide, L-arginyl-L-isoleucyl-L-lysyl-L-isoleucylglycyl-L-leucyl-L-phenylalanyl-L-α-aspartyl-L-glutaminyl-L-leucyl-L-seryl-L-arginyl- POMPILIDOTOXIN 216064-36-7 C71H124N22O17 Sodium Channel Modulators Voltage-gated Ion Channels Other Sodium Channel Modulators Ion Channels Monovalent Ion Channels Cell Signaling and Neuroscience Cell Biology BioChemical
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