6-BROMO-1,2,3,4-TETRAHYDROQUINOLINE
- CAS No.
- 22190-35-8
- Chemical Name:
- 6-BROMO-1,2,3,4-TETRAHYDROQUINOLINE
- Synonyms
- TIMTEC-BB SBB013968;UKRORGSYN-BB BBV-052938;6-BROMO-1,2,3,4-TETRAHYDROQUINOLINE;206-Bromo-1,2,3,4-Tetrahydroquinoline;quinoline, 6-bromo-1,2,3,4-tetrahydro-;6-BROMO-1,2,3,4-TETRAHYDROQUINOLINE，97% min;6-broMo-1,2,3,4-tetrahydroquinoline hydrocholide;6-BROMO-1,2,3,4-TETRAHYDRO-QUINOLINE HCL 6-BROMO-1,2,3,4-TETRAHYDRO-QUINOLINE
- CBNumber:
- CB5391516
- Molecular Formula:
- C9H10BrN
- Molecular Weight:
- 212.09
- MDL Number:
- MFCD04966989
- MOL File:
- 22190-35-8.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 6-Bromo-1,2,3,4-tetrahydroquinoline 95+% | B14749 | 250mg | $18 |
| 6-Bromo-1,2,3,4-tetrahydroquinoline 95+% | B14749 | 1g | $23 |
| 6-Bromo-1,2,3,4-tetrahydroquinoline 95+% | B14749 | 5g | $40 |
| 6-Bromo-1,2,3,4-tetrahydroquinoline 95+% | B14749 | 10g | $70 |
| 6-Bromo-1,2,3,4-tetrahydroquinoline 95+% | B14749 | 25g | $140 |
| More product size | |||
| Boiling point | 303.1±31.0 °C(Predicted) |
|---|---|
| Density | 1.428±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C(protect from light) |
| pka | 4.26±0.20(Predicted) |
| form | low melting solid |
| color | Light yellow to brown |
| InChI | InChI=1S/C9H10BrN/c10-8-3-4-9-7(6-8)2-1-5-11-9/h3-4,6,11H,1-2,5H2 |
| InChIKey | WEHMHBSITKCQBY-UHFFFAOYSA-N |
| SMILES | N1C2=C(C=C(Br)C=C2)CCC1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| HazardClass | IRRITANT |
| HS Code | 2933499090 |
6-BROMO-1,2,3,4-TETRAHYDROQUINOLINE price More Price(54)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Synthonix | B14749 | 6-Bromo-1,2,3,4-tetrahydroquinoline 95+% | 22190-35-8 | 250mg | $18 | 2026-05-06 | Buy |
| Synthonix | B14749 | 6-Bromo-1,2,3,4-tetrahydroquinoline 95+% | 22190-35-8 | 1g | $23 | 2026-05-06 | Buy |
| Synthonix | B14749 | 6-Bromo-1,2,3,4-tetrahydroquinoline 95+% | 22190-35-8 | 5g | $40 | 2026-05-06 | Buy |
| Synthonix | B14749 | 6-Bromo-1,2,3,4-tetrahydroquinoline 95+% | 22190-35-8 | 10g | $70 | 2026-05-06 | Buy |
| Synthonix | B14749 | 6-Bromo-1,2,3,4-tetrahydroquinoline 95+% | 22190-35-8 | 25g | $140 | 2026-05-06 | Buy |
6-BROMO-1,2,3,4-TETRAHYDROQUINOLINE Chemical Properties,Uses,Production
Synthesis
635-46-1
22190-35-8
General steps: 1. Bromination reaction: To a stirred acetonitrile solution of 1,2,3,4-tetrahydroquinoline (20.0 g, 150 mmol, 1.0 eq.) was added N-bromosuccinimide (25.5 g, 143 mmol, 0.95 eq.) in 4 portions at 0°C, each 20 minutes apart. The reaction mixture was continued to be stirred for 3 h at 0 °C. 2. Reaction monitoring: the progress of the reaction was monitored by thin layer chromatography (TLC), the unfolding agent was 10% ethyl acetate-hexane and the product Rf value was 0.55. 3. Post-treatment: After completion of the reaction, the organic layer was diluted with the addition of ether and washed sequentially with saturated sodium bicarbonate solution, water and brine. The organic phase was dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure. 4. Purification: The crude product was purified by column chromatography on silica gel (100-200 mesh) with hexane solution of 5% ethyl acetate as eluent to give 6-bromo-1,2,3,4-tetrahydroquinoline (20.0 g, 64% yield) as a yellow oil. 5. Characterization of the product: Liquid chromatography-mass spectrometry (LCMS) analysis showed a purity of 92.25% (ES+): m/z 212.0 (M+H+); retention time (tr) = 2.06 min.
References
[1] Tetrahedron, 2005, vol. 61, # 16, p. 4035 - 4041
[2] Patent: WO2012/94462, 2012, A2. Location in patent: Page/Page column 60
[3] Patent: US2008/221160, 2008, A1. Location in patent: Page/Page column 11; 12
[4] Patent: EP2172453, 2010, A1. Location in patent: Page/Page column 11
[5] Patent: WO2013/166015, 2013, A1. Location in patent: Paragraph 0093 - 0095
6-BROMO-1,2,3,4-TETRAHYDROQUINOLINE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3009 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Accela ChemBio Inc. | +1-858-6993322 +86-18019713315 | info@accelachem.com | United States | 21193 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | sales@conier.com | China | 49979 | 58 | |
| career henan chemical co | +86-0371-86658258 | factory@coreychem.com | China | 29793 | 58 |
| QINGDAO KAIENSI INTERNATIONAL TRADE CO.,LTD. | +86-0532-8699-9256 +86-18518128472 | kaley@cnfdevelop.com | China | 1410 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| SIMAGCHEM CORP | +86-5922680277 +86-13806087780 | sale@simagchem.com | China | 17346 | 58 |
View Lastest Price from 6-BROMO-1,2,3,4-TETRAHYDROQUINOLINE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2020-01-05 | 6-BROMO-1,2,3,4-TETRAHYDROQUINOLINE
22190-35-8
|
$1.00 | 1KG | 99% | 200kg | Career Henan Chemical Co |
-
- 6-BROMO-1,2,3,4-TETRAHYDROQUINOLINE
22190-35-8
- $1.00
- 99%
- Career Henan Chemical Co
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