NICOTINIC ACID HYDRAZIDE
- CAS No.
- 553-53-7
- Chemical Name:
- NICOTINIC ACID HYDRAZIDE
- Synonyms
- NICOTINIC HYDRAZIDE;ws102;Niazid;WS 102;NSC 36088;3-Isoniazid;WLN: T6NJ CVMZ;AKOS BBS-00004102;NICOTINOHYDRAZIDE;Nicotinylhydrazide
- CBNumber:
- CB5491636
- Molecular Formula:
- C6H7N3O
- Molecular Weight:
- 137.14
- MDL Number:
- MFCD00006383
- MOL File:
- 553-53-7.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| Nicotinic hydrazide 97% | 107425 | 25g | $103 |
| Nicotinic hydrazide 97% | 107425 | 100g | $328 |
| Nicotinic Acid Hydrazide >98.0%(GC)(T) | N0087 | 25g | $27 |
| Nicotinic Acid Hydrazide >98.0%(GC)(T) | N0087 | 100g | $73 |
| 3-Isoniazid | FI24684 | 50g | $150 |
| More product size | |||
| Melting point | 159-161 °C(lit.) |
|---|---|
| Boiling point | 251.97°C (rough estimate) |
| Density | 1.2620 (rough estimate) |
| refractive index | 1.6910 (estimate) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | H2O: soluble50mg/mL |
| pka | 11.43±0.10(Predicted) |
| form | Fine Needle-Like Crystalline Powder |
| color | White to off-white |
| Water Solubility | Soluble in alcohol, water. |
| BRN | 119299 |
| InChI | InChI=1S/C6H7N3O/c7-9-6(10)5-2-1-3-8-4-5/h1-4H,7H2,(H,9,10) |
| InChIKey | KFUSANSHCADHNJ-UHFFFAOYSA-N |
| SMILES | C1=NC=CC=C1C(NN)=O |
| CAS DataBase Reference | 553-53-7(CAS DataBase Reference) |
| FDA UNII | AF1LLO72TM |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H319 | |||||||||
| Precautionary statements | P264-P280-P305+P351+P338-P337+P313 | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 22-26-36/37/39 | |||||||||
| RIDADR | UN2811 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | QT1750000 | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29280000 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 | |||||||||
| Toxicity | LD50 intravenous in mouse: 180mg/kg | |||||||||
| NFPA 704 |
|
NICOTINIC ACID HYDRAZIDE price More Price(50)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 107425 | Nicotinic hydrazide 97% | 553-53-7 | 25g | $103 | 2026-04-30 | Buy |
| Sigma-Aldrich | 107425 | Nicotinic hydrazide 97% | 553-53-7 | 100g | $328 | 2023-06-20 | Buy |
| TCI Chemical | N0087 | Nicotinic Acid Hydrazide >98.0%(GC)(T) | 553-53-7 | 25g | $27 | 2026-04-30 | Buy |
| TCI Chemical | N0087 | Nicotinic Acid Hydrazide >98.0%(GC)(T) | 553-53-7 | 100g | $73 | 2026-04-30 | Buy |
| Biosynth | FI24684 | 3-Isoniazid | 553-53-7 | 50g | $150 | 2026-06-04 | Buy |
NICOTINIC ACID HYDRAZIDE Chemical Properties,Uses,Production
Chemical Properties
WHITE TO OFF-WHITE FINE NEEDLE-LIKE CRYST. POWDER
Uses
Nicotinic hydrazide was used in hydrazone library formation. It was used to study the oxidation of isonicotinic acid hydrazide (isoniazid) by horseradish peroxidase.
Uses
An Impurity of Isoniazid (I821450), potent antitubercular agent against M. tuberculosis.
Biochem/physiol Actions
Nicotinic hydrazide is an inhibitor of peroxidase enzyme. It forms solid metal complexes having strong biological activity.
Synthesis
93-60-7
553-53-7
The general procedure for the synthesis of 3-pyridinecarbohydrazide from methyl nicotinate was as follows: accurately weigh methyl 3-pyridinecarboxylate (2.74 g, 20 mmol) in a 50 mL round-bottomed flask, add anhydrous ethanol (15 mL), and stir at room temperature until the solid was completely dissolved. Subsequently, 80% hydrazine hydrate (30 mmol) was slowly added dropwise and immediately a large amount of needle-like white solid was observed to precipitate. The reaction mixture was continued to be stirred at room temperature for 3 h. Upon completion of the reaction, diafiltration was carried out and the solid was washed with a small amount of ethanol, resulting in 2.56 g of white needle-like crystals in 93.2% yield.
Purification Methods
Crystallise it from aqueous EtOH or *benzene. [Beilstein 22 III/IV 439, 22/2 V 121.]
References
[1] Bioorganic and Medicinal Chemistry, 2003, vol. 11, # 7, p. 1381 - 1387
[2] Patent: CN104592217, 2018, B. Location in patent: Paragraph 0032; 0033; 0034
[3] Patent: WO2017/11466, 2017, A1. Location in patent: Paragraph 00473
[4] Bioorganic and Medicinal Chemistry, 2012, vol. 20, # 6, p. 2158 - 2171
[5] Patent: CN108484582, 2018, A. Location in patent: Paragraph 0031; 0036; 0037; 0038; 0039
NICOTINIC ACID HYDRAZIDE Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Daken Advanced Materials Co.,Ltd | +86-2158073036 | info@dakenam.com | China | 14026 | 58 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29812 | 58 |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 8497 | 58 |
| Changzhou Ditong Chemical Co.,Ltd | +86-0519-88298848 | info@edengenechem.com | China | 2165 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | sales@conier.com | China | 49979 | 58 | |
| Jinan Liheng Biotechnology Co., Ltd. | 15865262812 | info@lihengpharm.com | CHINA | 938 | 58 |
| Zhengzhou Alfa Chemical Co.,Ltd | +86-18530059196 | sale04@alfachem.cn | China | 9612 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32468 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +86-189 4982 3763 | sales@tnjchem.com | China | 34563 | 58 |
View Lastest Price from NICOTINIC ACID HYDRAZIDE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2021-07-13 | NICOTINIC ACID HYDRAZIDE
553-53-7
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd | ||
 |
2021-07-10 | NICOTINIC ACID HYDRAZIDE
553-53-7
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd | ||
 |
2019-07-06 | NICOTINIC ACID HYDRAZIDE
553-53-7
|
$1.00 | 1KG | 99% | Career Henan Chemical Co |
-
- NICOTINIC ACID HYDRAZIDE
553-53-7
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- NICOTINIC ACID HYDRAZIDE
553-53-7
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- NICOTINIC ACID HYDRAZIDE
553-53-7
- $1.00
- 99%
- Career Henan Chemical Co
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