5-BROMO-6-BROMOMETHYL-1 3-BENZODIOXOLE
- CAS No.
- 5434-47-9
- Chemical Name:
- 5-BROMO-6-BROMOMETHYL-1 3-BENZODIOXOLE
- Synonyms
- 5-broMo-6-(broMoMethyl)benzo[d][1,3]dioxole;5-Bromo-6-(bromomethyl)-1,3-dioxaindane;alpha,2-dibromo-4,5-methylenedioxy-toluen;1,3-Benzodioxole, 5-bromo-6-(bromomethyl)-;5-Bromo-6-bromomethyl-1,3-benzodioxole 96%
- CBNumber:
- CB5498897
- Molecular Formula:
- C8H6Br2O2
- Molecular Weight:
- 293.94
- MDL Number:
- MFCD00230428
- MOL File:
- 5434-47-9.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 5-Bromo-6-bromomethyl-1,3-benzodioxole 96% | 653748 | 5g | $76.9 |
| 5-Bromo-6-bromomethyl-1,3-benzodioxole 96% | 653748 | 25g | $239 |
| 5-Bromo-6-bromomethyl-1,3-benzodioxole | FAA43447 | 10g | $354 |
| 5-Bromo-6-(Bromomethyl)Benzo[d][1,3]Dioxole ≥98% | AA00345F | 1g | $34 |
| 5-Bromo-6-(Bromomethyl)Benzo[d][1,3]Dioxole ≥98% | AA00345F | 5g | $118 |
| Melting point | 91-95 °C |
|---|---|
| Boiling point | 322.9±42.0 °C(Predicted) |
| Density | 2.009±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| form | solid |
| Appearance | White to off-white Solid |
| InChI | 1S/C8H6Br2O2/c9-3-5-1-7-8(2-6(5)10)12-4-11-7/h1-2H,3-4H2 |
| InChIKey | FDCXAYVCUJDBJU-UHFFFAOYSA-N |
| SMILES | BrCc1cc2OCOc2cc1Br |
| FDA UNII | 3YPQ3WT85L |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS05 |
|---|---|
| Signal word | Danger |
| Hazard statements | H314 |
| Precautionary statements | P260-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338-P363 |
| PPE | Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges |
| Hazard Codes | C,N |
| Risk Statements | 34-51/53 |
| Safety Statements | 26-36/37/39-45-60-61 |
| RIDADR | UN 3261 8/PG 2 |
| WGK Germany | 3 |
| RTECS | XT0570000 |
| Storage Class | 8A - Combustible corrosive hazardous materials |
| Hazard Classifications | Skin Corr. 1B |
5-BROMO-6-BROMOMETHYL-1 3-BENZODIOXOLE price More Price(17)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 653748 | 5-Bromo-6-bromomethyl-1,3-benzodioxole 96% | 5434-47-9 | 5g | $76.9 | 2023-01-07 | Buy |
| Sigma-Aldrich | 653748 | 5-Bromo-6-bromomethyl-1,3-benzodioxole 96% | 5434-47-9 | 25g | $239 | 2023-01-07 | Buy |
| Biosynth | FAA43447 | 5-Bromo-6-bromomethyl-1,3-benzodioxole | 5434-47-9 | 10g | $354 | 2026-06-04 | Buy |
| aablocks | AA00345F | 5-Bromo-6-(Bromomethyl)Benzo[d][1,3]Dioxole ≥98% | 5434-47-9 | 1g | $34 | 2026-05-28 | Buy |
| aablocks | AA00345F | 5-Bromo-6-(Bromomethyl)Benzo[d][1,3]Dioxole ≥98% | 5434-47-9 | 5g | $118 | 2026-05-28 | Buy |
5-BROMO-6-BROMOMETHYL-1 3-BENZODIOXOLE Chemical Properties,Uses,Production
Synthesis
120-57-0
5434-47-9
The general procedure for the synthesis of 5-bromo-6-(bromomethyl)benzo[d][1,3]dioxole from piperonal was as follows: bromine (3.36 g, 21 mmol) was added slowly and dropwise to a solution of piperonal (3.0 g, 20 mmol) in chloroform (15 mL). The reaction mixture was heated to 60 °C and the reaction was stirred at this temperature for 12 hours. Upon completion of the reaction, the mixture was cooled to room temperature and diluted with the addition of dichloromethane (60 mL). Subsequently, the organic phase was washed sequentially with saturated aqueous sodium bicarbonate (2 x 20 mL) and brine (20 mL), and the organic layer was dried with anhydrous sodium sulfate. The solvent was removed by concentration under reduced pressure to give the crude product 5-bromo-6-(bromomethyl)benzo[d][1,3]dioxole (5.88 g, 100% yield), which solidified on standing. A portion of the crude product (2.44 g, 8.33 mmol) was taken and dissolved in tetrahydrofuran and the solution was cooled to -78 °C. Under nitrogen protection, lithium aluminum hydride (348 mg, 9.16 mmol) was added in batches and the reaction was stirred at -78 °C for 3 hours. Subsequently, lithium aluminum hydride (80 mg, 2.03 mmol) was added and stirring was continued for 1 hour. Upon completion of the reaction, ethyl acetate was carefully added to quench the excess lithium aluminum hydride, followed by methanol (20 mL). The insoluble salt was removed by filtration and the filtrate was concentrated under reduced pressure to afford the target product 5-bromo-6-(bromomethyl)benzo[d][1,3]dioxole (1.76 g, 99% yield), which could be used in the subsequent reaction without further purification. The product was characterized by 1H-NMR (CDCl3): δ 7.01 (s, 1H), 6.73 (s, 1H), 5.95 (s, 2H), 2.32 (s, 3H).
References
[1] Patent: WO2003/99805, 2003, A1. Location in patent: Page 418-419
5-BROMO-6-BROMOMETHYL-1 3-BENZODIOXOLE Preparation Products And Raw materials
5-BROMO-6-BROMOMETHYL-1 3-BENZODIOXOLE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3009 | 60 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
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| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Energy Chemical | 021-021-58432009 400-005-6266 | sales8178@energy-chemical.com | China | 44878 | 61 |
| Syntechem Co.,Ltd | info@syntechem.com | China | 12984 | 57 | |
| Shanghai Run-Biotech Co., Ltd. | 021-57171705 13817537615 | sales@run-biotech.com | China | 2319 | 58 |
| Bide Pharmatech Ltd. | 400-400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51395 | 80 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 13636370518 | shyysw007@163.com | China | 89686 | 60 |
