2-Amino-5-hydroxypyrimidine
- CAS No.
- 143489-45-6
- Chemical Name:
- 2-Amino-5-hydroxypyrimidine
- Synonyms
- 2-Amino-5-pyrimidinol;2-Amino-pyrimidin-5-ol;5-Pyrimidinol, 2-amino-;2-Amido-5-hydroxyprimidine;2-Amino-5-hydroxypyrimidine;2-AMino-5-hydroxypyriMidi...;5-Pyrimidinol, 2-amino- (9CI);2-Amino-5-hydroxypyrimidine ISO 9001：2015 REACH;2-Aminopyrimidin-5-ol, 5-Hydroxypyrimidin-2-amine
- CBNumber:
- CB5506653
- Molecular Formula:
- C4H5N3O
- Molecular Weight:
- 111.1
- MDL Number:
- MFCD08062411
- MOL File:
- 143489-45-6.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 2-Amino-5-hydroxypyrimidine (2-Amino-pyrimidin-5-ol) | A1378-19 | 500mg | $602 |
| 2-Amino-5-hydroxypyrimidine Asreported | 258502 | 1g | $531 |
| 2-Amino-5-hydroxypyrimidine Asreported | 258502 | 2g | $744 |
| 2-Amino-5-hydroxypyrimidine Asreported | 258502 | 5g | $1068 |
| 2-Amino-5-hydroxypyrimidine Asreported | 258502 | 10g | $1480 |
| More product size | |||
| Melting point | >170°C (dec.) |
|---|---|
| Boiling point | 393.6±34.0 °C(Predicted) |
| Density | 1.450±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,2-8°C |
| solubility | DMSO (Slightly), Methanol (Slightly, Sonicated) |
| pka | 3.95±0.23(Predicted) |
| form | Powder or Crystalline Powder |
| color | White to yellow |
| CAS DataBase Reference | 143489-45-6(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| Hazard Codes | Xn |
| Risk Statements | 20/21/22-36/37/38 |
| Safety Statements | 26-36-36/37/39 |
| HazardClass | IRRITANT |
| HS Code | 25010019 |
2-Amino-5-hydroxypyrimidine price More Price(61)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | A1378-19 | 2-Amino-5-hydroxypyrimidine (2-Amino-pyrimidin-5-ol) | 143489-45-6 | 500mg | $602 | 2026-06-03 | Buy |
| Usbiological | 258502 | 2-Amino-5-hydroxypyrimidine Asreported | 143489-45-6 | 1g | $531 | 2026-06-03 | Buy |
| Usbiological | 258502 | 2-Amino-5-hydroxypyrimidine Asreported | 143489-45-6 | 2g | $744 | 2026-06-03 | Buy |
| Usbiological | 258502 | 2-Amino-5-hydroxypyrimidine Asreported | 143489-45-6 | 5g | $1068 | 2026-06-03 | Buy |
| Usbiological | 258502 | 2-Amino-5-hydroxypyrimidine Asreported | 143489-45-6 | 10g | $1480 | 2026-06-03 | Buy |
2-Amino-5-hydroxypyrimidine Chemical Properties,Uses,Production
Chemical Properties
White Solid
Uses
2-Aminopyrimidin-5-ol is an endogenous metabolite.
Definition
ChEBI: 2-Amino-5-hydroxypyrimidine is a hydroxypyrimidine.
Synthesis
13418-77-4
143489-45-6
Boron tribromide (2.6 mL, 50 mmol) was slowly added dropwise to a benzene solution (60 mL) containing 5-methoxy-2-aminopyrimidine (1.25 g, 10 mmol) under argon protection. The reaction mixture was stirred under reflux conditions for 6 hours. After completion of the reaction, the mixture was allowed to stand at room temperature overnight. Subsequently, the solvent was removed by rotary evaporator and the residue was carefully treated with ice-cold deionized water (10 mL). The solution pH was adjusted to 6-7 using 6N hydrochloric acid and subsequently extracted with ethyl acetate. The organic phase was washed with saturated saline, dried over anhydrous sodium sulfate and filtered. The filtrate was concentrated to give a yellow solid, which was purified by column chromatography (eluent ratio of 20:1 dichloromethane to methanol) to give 840 mg (75% yield) of 2-aminopyrimidin-5-ol as a white solid. The structure of the product was confirmed by 1H-NMR and electron bombardment mass spectrometry (EI-MS).1H NMR (DMSO-d6) δ 8.90 (s, 1H), 7.86 (s, 2H), 5.91 (s, 2H); EI-MS (m/z) 111 (M+).
References
[1] European Journal of Medicinal Chemistry, 1992, vol. 27, # 3, p. 207 - 217
[2] Patent: US2009/105269, 2009, A1. Location in patent: Page/Page column 10
[3] Journal of Medicinal Chemistry, 2010, vol. 53, # 3, p. 1117 - 1127
2-Amino-5-hydroxypyrimidine Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29812 | 58 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10403 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 +86-18019713315 | info@accelachem.com | United States | 21193 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | sales@conier.com | China | 49979 | 58 | |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569262 +86-15003564040 | 1056@dideu.com | China | 3971 | 58 |
| Antai Fine Chemical Technology Co.,Limited | 18503026267 | info@antaichem.com | CHINA | 9636 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
View Lastest Price from 2-Amino-5-hydroxypyrimidine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-02-02 | 2-Amino-5-hydroxypyrimidine
143489-45-6
|
$1.00 | 1g | 99% | 50ton | Shaanxi Dideu Medichem Co. Ltd | |
 |
2025-11-18 | 2-Amino-5-hydroxypyrimidine
143489-45-6
|
$1.10 | 1g | 99.00% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2021-07-13 | 2-Amido-5-hydroxyprimidine
143489-45-6
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd |
-
- 2-Amino-5-hydroxypyrimidine
143489-45-6
- $1.00
- 99%
- Shaanxi Dideu Medichem Co. Ltd
-
- 2-Amino-5-hydroxypyrimidine
143489-45-6
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- 2-Amido-5-hydroxyprimidine
143489-45-6
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
