Source

Rabbit

Reactivity

Human;Mouse;Rat

Background

Collapsin Response Mediator Protein-2 is expressed at high levels in the developing nervous system and plays a critical role in axonal outgrowth by specifying axon/dendrite fate and establishing neuronal polarity. CRMP-2 enhances axon elongation and branching by binding to tubulin heterodimers to promote microtubule assembly. GSK-3β inactivates CRMP-2 by phosphorylating it at Thr514. CRMP-2 is primed following phosphorylation at Ser522 by CDK5 and at Thr518 by GSK-3β. Phosphorylation of CRMP-2, which decreases tubulin binding ability, can be inhibited by NT-3 and BDNF through the PI3 kinase/Akt pathway. CRMP-2 also mediates semaphorin-induced growth cone collapse. Hyperphosphorylation of CRMP-2 is found in Alzheimer disease plaques with concurrent elevated GSK-3β activity in these patients.

References

[1] Gu, Y. and Ihara, Y. (2000) J Biol Chem 275, 17917-20.
[2] Yoshimura, T. et al. (2005) Cell 120, 137-49.
[3] Fukata, Y. et al. (2002) Nat Cell Biol 4, 583-91.
[4] Goshima, Y. et al. (1995) Nature 376, 509-14.
[5] Cole, A.R. et al. (2004) J Biol Chem 279, 50176-80.

Raw materials

Preparation Products