Source

Rabbit

Reactivity

Human;Mouse;Rat;Monkey;Pig

Background

c-Jun is a member of the Jun family containing c-Jun, JunB, and JunD, and is a component of the transcription factor activator protein-1. AP-1 is composed of dimers of Fos, Jun, and ATF family members and binds to and activates transcription at TRE/AP-1 elements. Extracellular signals, including growth factors, chemokines, and stress, activate AP-1-dependent transcription. The transcriptional activity of c-Jun is regulated by phosphorylation at Ser63 and Ser73 through SAPK/JNK. Knockout studies in mice have shown that c-Jun is essential for embryogenesis, and subsequent studies have demonstrated roles for c-Jun in various tissues and developmental processes, including axon regeneration, liver regeneration, and T cell development. AP-1 regulated genes exert diverse biological functions, including cell proliferation, differentiation, and apoptosis, as well as transformation, invasion and metastasis, depending on cell type and context. Other target genes regulate survival, as well as hypoxia and angiogenesis. Research studies have implicated c-Jun as a promising therapeutic target for cancer, vascular remodeling, acute inflammation, and rheumatoid arthritis.

References

[1] Jochum, W. et al. (2001) Oncogene 20, 2401-12.
[2] Davis, R.J. (2000) Cell 103, 239-52.
[3] Hilberg, F. et al. (1993) Nature 365, 179-81.
[4] Raivich, G. et al. (2004) Neuron 43, 57-67.
[5] Behrens, A. et al. (2002) EMBO J 21, 1782-90.
[6] Riera-Sans, L. and Behrens, A. (2007) J Immunol 178, 5690-700.
[7] Lepp?, S. and Bohmann, D. (1999) Oncogene 18, 6158-62.
[8] Shaulian, E. and Karin, M. (2002) Nat Cell Biol 4, E131-6.
[9] Weiss, C. and Bohmann, D. (2004) Cell Cycle 3, 111-3.
[10] Karamouzis, M.V. et al. (2007) Mol Cancer Res 5, 109-20.

Raw materials

Preparation Products