Source

Rabbit

Reactivity

Human;Mouse;Rat;Monkey

Background

Neurofibromatosis 2 is an autosomal dominant, inherited disorder characterized by the occurrence of vestibular schwannomas, meningiomas, and other nervous system tumors. Both the familial tumors of NF2 and equivalent sporadic tumors found in the general population are caused by inactivation of the NF2 tumor suppressor gene. Merlin is the NF2 gene product, displaying striking similarity to ezrin, radixin, and moesin proteins. Regulation of merlin and ERM proteins involves intramolecular and intermolecular head-to-tail associations between family members. Merlin and ERM proteins act as linkers between the plasma membrane and the cytoskeleton, affecting cell morphology, polarity, and signal transduction. Merlin is phosphorylated by the Rac/Cdc42 effector p21-activated kinase at Ser518, negatively regulating Rac.

References

[1] Ramesh, V. (2004) Nat. Rev. Neurosci. 5, 462-70.
[2] Bretscher, A. et al. (2002) Nat. Rev. Mol. Cell Biol. 3, 586-99.
[3] Xiao, G. H. et al. (2002) J. Biol. Chem. 277, 883-6.
[4] Kissil, J. L. et al. (2003) Mol. Cell 12, 841-9.

Raw materials

Preparation Products