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ISG15 (22D2) Rabbit mAb

CAS No.
Chemical Name:
ISG15 (22D2) Rabbit mAb
Synonyms
ISG15 (22D2) Rabbit mAb
CBNumber:
CB55738538
Molecular Formula:
Molecular Weight:
0
MDL Number:
MOL File:
Mol file

ISG15 (22D2) Rabbit mAb Chemical Properties,Uses,Production

Source

Rabbit

Reactivity

Human

Background

Interferon-stimulated 15 kDa protein, also known as ubiquitin cross-reactive protein, is a member of the ubiquitin-like protein family and functions in various biological pathways from pregnancy to innate immune responses. Expression of ISG15 is stimulated by cellular exposure to type 1 interferons α and β, in addition to infection with viruses such as influenza B. After exposure to type I interferons, both lymphocytes and monocytes, in addition to some fibroblasts and epithelial cells, release ISG15 into culture medium. ISG15 has been shown to function as a cytokine, stimulating interferon γ secretion by monocytes and macrophages, proliferation of natural killer cells, and chemotactic responses in neutrophils. ISG15 has also been shown to function intracellularly, being covalently conjugated to other proteins by E1, E2 and E3 ligases via a multi-step process analogous to ubiquitination. ISG15 is removed from proteins by the ubiquitin processing protease Ubp43. ISG15-protein conjugation is induced by type 1 interferons, and target proteins include the serine protease inhibitor Serpin 2A, PLCγ1, ERK1/2, Jak1 and Stat1. Unlike ubiquitination, ISGylation does not target proteins for degradation, rather ISGylation increases Jak1 and Stat1 activity, enhancing the cellular response to interferons.

References

[1] Ritchie, K.J. and Zhang, D.E. (2004) Semin. Cell Dev. Biol. 15, 237-246.
[2] Korant, B.D. et al. (1984) J. Biol. Chem. 259, 14835-14839.
[3] Haas, A.L. et al. (1987) J. Biol. Chem. 262, 11315-11323.
[4] Knight, E. and Cordova, B. (1991) J. Immunol. 146, 2280-2284.
[5] D'Cunha, J. et al. (1996) Proc. Natl. Acad. Sci. USA 93, 211-215.
[6] Loeb, K.R. and Haas, A.L. (1992) J. Biol. Chem. 267, 7806-7813.
[7] Zhao, C. et al. (2005) Proc. Natl. Acad. Sci. USA 102, 10200-10205.
[8] Malakhov, M.P. et al. (2002) J. Biol. Chem. 277, 9976-9981.
[9] Malakhov, M.P. et al. (2003) J. Biol. Chem. 278, 16608-16613.
[10] Hamerman, J.A. et al. (2002) J. Immunol. 168, 2415-2423.

ISG15 (22D2) Rabbit mAb Preparation Products And Raw materials

Raw materials

Preparation Products

ISG15 (22D2) Rabbit mAb Suppliers

Global( 6)Suppliers
Supplier Tel Email Country ProdList Advantage
Shanghai Universal Biotech Co.,Ltd 15921930842 15921930842 yh-wang@univ-bio.com China 25021 58
Cell Signaling Technology Inc 21-80243558 86218024 info@cellsignal.cn China 6427 58
Hangzhou Novas Biotechnology Co., Ltd. 15264006066 CHINA 1844 58
ISG15 (22D2) Rabbit mAb
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