Source

Rabbit

Reactivity

Human;Mouse;Rat;Monkey

Background

Kinesin superfamily proteins are molecular motors that drive directional, microtubule-dependent intracellular transport of membrane-bound organelles and other macromolecules. The intracellular transport functions of KIFs are fundamentally important for a variety of cellular functions, including mitotic and meiotic division, motility/migration, hormone and neurotransmitter release, and differentiation. Disruptions to KIF-mediated intracellular transport have been linked with a variety of pathologies, ranging from tumorigenesis to defects in higher order brain function such as learning and memory.Kinesin superfamily protein 3A is a central component of the kinesin-2 protein complex. KIF3A and its paralog KIF3B bind to form a heterodimeric motor protein with ATP-dependent, plus-end-directed microtubule sliding activity. The tail domain of this heterodimer binds to kinesin-associated protein 3, which facilitates binding of the KIF3A/3B motor protein to its cargo. Recent studies in a variety of model organisms have demonstrated a critical role for kinesin-family proteins, including KIF3A, in the formation and function of cilia. Notably, KIF3A was shown to mediate cilia-dependent protein-protein interactions that function to transduce canonical Hedgehog signaling.

References

[1] Hirokawa, N. et al. (2009) Nat Rev Mol Cell Biol 10, 682-96.
[2] Yu, Y. and Feng, Y.M. (2010) Cancer 116, 5150-60.
[3] Park, J.J. et al. (2008) Mol Endocrinol 22, 989-1005.
[4] Hirokawa, N. et al. (2010) Neuron 68, 610-38.
[5] Yoshimura, Y. et al. (2010) Mol Cell Biol 30, 2206-19.
[6] Hirokawa, N. and Noda, Y. (2008) Physiol Rev 88, 1089-118.
[7] Haraguchi, K. et al. (2006) J Biol Chem 281, 4094-9.
[8] Yamazaki, H. et al. (1995) J Cell Biol 130, 1387-99.
[9] Zhao, C. et al. (2012) Proc Natl Acad Sci U S A 109, 2388-93.
[10] Humke, E.W. et al. (2010) Genes Dev 24, 670-82.

Raw materials

Preparation Products