Source

Rabbit

Reactivity

Human;Mouse;Rat

Background

Enzymes of the phosphodiesterase superfamily catalyze the hydrolysis of 3',5'-cyclic nucleotides into the corresponding nucleotide 5'-monophosphates. The PDE superfamily includes 11 subfamilies in mammals. These enzymes function as important positive and negative regulators of cellular response, including regulation of insulin secretion, heart function, erectile function, and inflammation. The cAMP-specific phosphodiesterase 4B is important for the inflammatory response to lipopolysaccharide in monocytes. PDE4B plays an important role in the hydrolysis and inactivation of the ubiquitous second messenger cAMP that regulates lymphocyte cell growth and apoptosis. Research studies indicate that PDE4B is also involved in psychiatric disorders, including schizophrenia, autism, and depression.

References

[1] Bender, A.T. and Beavo, J.A. (2006) Pharmacol Rev 58, 488-520.
[2] Dyachok, O. et al. (2006) Nature 439, 349-52.
[3] Fischmeister, R. et al. (2006) Circ Res 99, 816-28.
[4] Rosen, R.C. and Kostis, J.B. (2003) Am J Cardiol 92, 9M-18M.
[5] Smith, S.J. et al. (2004) Mol Pharmacol 66, 1679-89.
[6] Jin, S.L. and Conti, M. (2002) Proc Natl Acad Sci U S A 99, 7628-33.
[7] Conti, M. et al. (2003) J Biol Chem 278, 5493-6.
[8] Fatemi, S.H. et al. (2008) Schizophr Res 101, 36-49.
[9] Braun, N.N. et al. (2007) Neuroreport 18, 1841-4.
[10] Numata, S. et al. (2009) Am J Med Genet B Neuropsychiatr Genet 150B, 527-34.

Raw materials

Preparation Products