beta-Cyclodextrin methyl ethers
- CAS No.
- 128446-36-6
- Chemical Name:
- beta-Cyclodextrin methyl ethers
- Synonyms
- Methyl-β-cyclodextrin;METHYL-BETA-CYCLODEXTRIN;MBC;Me-β-CD;MBCD;Dimethyl-β-Cyclodextrin;Methyl-beta-cyclodextrine;MEBCD;MβCD);BETA-CYD
- CBNumber:
- CB5696215
- Molecular Formula:
- C54H94O35
- Molecular Weight:
- 1303.3
- MDL Number:
- MFCD00074980
- MOL File:
- 128446-36-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Methyl-β-cyclodextrin average Mn 1310 | 332615 | 5g | $57.8 |
| Methyl-β-cyclodextrin average Mn 1310 | 332615 | 25g | $188 |
| Methyl-β-cyclodextrin (mixture of several Methylated) | M1356 | 25g | $73 |
| Methyl-β-cyclodextrin (mixture of several Methylated) | M1356 | 250g | $370 |
| Methyl-β-cyclodextrin | 21633 | 5g | $46 |
| More product size | |||
| Melting point | 180-182 °C(lit.) |
|---|---|
| alpha | +159°(25℃, c=1, H2O) |
| Flash point | 187 °C |
| storage temp. | room temp |
| solubility | H2O: soluble50mg/mL |
| form | powder |
| color | White to off-white |
| biological source | synthetic (organic) |
| optical activity | [α]25/D +159°, c = 1 in H2O |
| Water Solubility | Soluble in water |
| Cosmetics Ingredients Functions | CHELATING |
| Cosmetic Ingredient Review (CIR) | beta-Cyclodextrin methyl ethers (128446-36-6) |
| InChIKey | YZOUYRAONFXZSI-SBHWVFSVSA-N |
| SMILES | O1C2OC(C(OC3OC(C(OC4OC(C(OC5OC(C(OC6OC(C(OC7OC(C(OC8OC(C1C(C8OC)O)COC)C(C7OC)O)COC)C(C6OC)O)COC)C(C5OC)O)COC)C(C4OC)O)COC)C(C3OC)O)COC)C(C2OC)O)COC |
| LogP | -2.566 (est) |
| FDA UNII | F9TVU546K5 |
| EPA Substance Registry System | .beta.-Cyclodextrin, methyl ethers (128446-36-6) |
| Absorption |
≤0.10 at 350-600nm in solution at 10% ≤1.00 at 220-350nm in solution at 10% |
| UNSPSC Code | 12352201 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H317-H361 | |||||||||
| Precautionary statements | P201-P202-P261-P272-P280g-P302+P352-P308+P313-P363-P403-P501c | |||||||||
| Safety Statements | 22-24/25 | |||||||||
| WGK Germany | 3 | |||||||||
| TSCA | TSCA listed | |||||||||
| HS Code | 35051000 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
beta-Cyclodextrin methyl ethers price More Price(69)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 332615 | Methyl-β-cyclodextrin average Mn 1310 | 128446-36-6 | 5g | $57.8 | 2026-04-30 | Buy |
| Sigma-Aldrich | 332615 | Methyl-β-cyclodextrin average Mn 1310 | 128446-36-6 | 25g | $188 | 2026-04-30 | Buy |
| TCI Chemical | M1356 | Methyl-β-cyclodextrin (mixture of several Methylated) | 128446-36-6 | 25g | $73 | 2026-04-30 | Buy |
| TCI Chemical | M1356 | Methyl-β-cyclodextrin (mixture of several Methylated) | 128446-36-6 | 250g | $370 | 2026-04-30 | Buy |
| Cayman Chemical | 21633 | Methyl-β-cyclodextrin | 128446-36-6 | 5g | $46 | 2026-04-30 | Buy |
beta-Cyclodextrin methyl ethers Chemical Properties,Uses,Production
Description
Methyl-β-cyclodextrin is a randomly methylated form of the cyclic oligosaccharide β-cyclodextrin . Methyl-β-cyclodextrin contains seven D-(+)-glucopyranose units that contain randomized hydrogen or methyl groups. Methyl-β-cyclodextrin has been used to improve the aqueous solubility of various compounds and to extract cholesterol from lipid membranes. Methyl-β-cyclodextrin (5 mM) reduces α-synuclein levels in the membrane and detergent-insoluble fractions from B103 neuroblastoma cells transfected with human α-synuclein. It also reduces α-synuclein levels in mouse brain in a transgenic model of α-synucleinopathy.
Chemical Properties
White powder
Uses
Methyl-β-cyclodextrin is a cholesterol-removing agent mainly used for lipid raft disruption. It may also be used for detergent removal from protein-lipid-detergent ternary mixture to produce 2D membrane protein crystals due to its high solubility and affinity for detergents generally used in membrane protein chemistry.
Uses
Cavity size is the major determinant as to which cyclodextrin is used in complexation. The cavity diameter of β-cyclodextrins or β-glucopyranose unit compounds is well-suited for use with molecules the size of hormones, vitamins and many compounds frequently used in tissue and cell culture applications. For this reason, β-cyclodextrin is most commonly used as a complexing agent. It is used to increase the solubility of non-polar substances such as fatty acids, lipids, vitamins and cholesterol for use in cell culture applications. Methyl-β-cyclodextrin is used to remove cholesterol from cultured cells and is employed to remove lipid rafts.
Uses
substrate for laminarinase and other glucanases
General Description
Methyl-β-cyclodextrin is a small cyclic heptasaccharide.
Biochem/physiol Actions
Methyl-β-cyclodextrin participates in increasing the permeability of cells. It also plays a role in depolymerizing the actin cytoskeleton in cells. Methyl-β-cyclodextrin is involved in attracting cholesterol from the plasma. It participates in activating extracellular receptor kinase in certain cells.
References
[1] MOJCA PODLESNIK BESENIAR . Kinetics of cholesterol extraction from lipid membranes by methyl-β-cyclodextrin—A surface plasmon resonance approach[J]. Biochimica et biophysica acta. Biomembranes, 2008, 1778 1: Pages 175-184. DOI: 10.1016/j.bbamem.2007.09.022
[2] PAZIT BAR-ON. Effects of the cholesterol-lowering compound methyl-β-cyclodextrin in models of α-synucleinopathy[J]. Journal of Neurochemistry, 2006, 98 4: 1032-1045. DOI: 10.1111/j.1471-4159.2006.04017.x
beta-Cyclodextrin methyl ethers Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Chuanghai Biotechnology Co., Ltd | +86-15350571055 | Sibel@chuanghaibio.com | China | 8737 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +86-17531190177 | faithe@yan-xi.com | China | 5838 | 58 |
| Wuhan Fortuna Chemical Co., Ltd | +86-27-59207850 | info@fortunachem.com | China | 5998 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-86-13131129325 | sales1@chuanghaibio.com | China | 5218 | 58 |
| airuikechemical co., ltd. | +86-18353166132 | sales02@airuikechemical.com | China | 983 | 58 |
| Hebei Zhuanglai Chemical Trading Co.,Ltd | 13343047651 | admin@zlchemi.com | China | 3689 | 58 |
| Shandong Deshang Chemical Co., Ltd. | +86-0531-8875-2665 +86-13153039501 | info@deshangchem.com | China | 659 | 58 |
| Shijiazhuang Byine Trading Co.,ltd | 19350938084 | mark@sjzbyine.com | China | 265 | 58 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-2158073036 | info@dakenam.com | China | 14032 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21531 | 55 |
View Lastest Price from beta-Cyclodextrin methyl ethers manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-07 | Methyl-Beta-Cyclodextrin
128446-36-6
|
1kg | 98%min | 500kg | WUHAN FORTUNA CHEMICAL CO., LTD | ||
 |
2026-07-24 | Beta-Cyclodextrin methyl ethers
128446-36-6
|
$10.00 | 1kg | 98% | 20tons | Nantong Provichem Biotech Co., Ltd. | |
 |
2026-07-14 | Methyl-β-cyclodextrin
128446-36-6
|
$33.00 | 99.00% | 10g | TargetMol Chemicals Inc. |
-
- Methyl-Beta-Cyclodextrin
128446-36-6
- 98%min
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- Beta-Cyclodextrin methyl ethers
128446-36-6
- $10.00
- 98%
- Nantong Provichem Biotech Co., Ltd.
-
- Methyl-β-cyclodextrin
128446-36-6
- $33.00
- 99.00%
- TargetMol Chemicals Inc.
