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ChemicalBook >> CAS DataBase List >>THIOPHENE-2-THIOCARBOXAMIDE

THIOPHENE-2-THIOCARBOXAMIDE

CAS No.
20300-02-1
Chemical Name:
THIOPHENE-2-THIOCARBOXAMIDE
Synonyms
THIOPHENE-2-CARBOTHIOAMIDE;THIOPHENE-2-THIOAMIDE;OTAVA-BB BB7020331311;2-Thiocarbamoylthiophene;2-Thienylthiocarboxamide;2-Thiophenecarbothioamide;Thiophen-2-carbothioamide;Thiophen-2-thiocarboxamid;2-Thiophenethiocarboxamide;THIOPHENE-2-THIOCARBOXAMIDE
CBNumber:
CB5697863
Molecular Formula:
C5H5NS2
Molecular Weight:
143.23
MDL Number:
MFCD00052890
MOL File:
20300-02-1.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-06-04 16:00:12
Product description Number Pack Size Price
Thiophene-2-carbothioamide AldrichCPR CDS014286 250 mg $77.9
Thiophene-2-carbothioamide >98.0%(HPLC) T3604 5g $403
Thiophene-2-carbothioamide >98.0%(HPLC) T3604 25g $1274
Thiophene-2-carbothioamide Asreported 290796 1g $375
Thiophene-2-carbothioamide Asreported 290796 2g $598
More product size

THIOPHENE-2-THIOCARBOXAMIDE Properties

Melting point 106 °C
Boiling point 260℃
Density 1.357
Flash point 111℃
storage temp. 2-8°C(protect from light)
form powder to crystal
pka 12.56±0.29(Predicted)
color White to Yellow to Green
Water Solubility Insoluble in water.
BRN 110159
InChI 1S/C5H5NS2/c6-5(7)4-2-1-3-8-4/h1-3H,(H2,6,7)
InChIKey HDXYHAPUCGQOBX-UHFFFAOYSA-N
SMILES NC(=S)c1cccs1
CAS DataBase Reference 20300-02-1(CAS DataBase Reference)
UNSPSC Code 12352200
NACRES NA.21

SAFETY

Risk and Safety Statements

Symbol(GHS)  Skull and Crossbones (GHS06)
GHS06
Signal word  Warning
Hazard statements  H301-H315-H319-H335
Precautionary statements  P280h-P305+P351+P338-P309-P310
Hazard Codes  Xi
Risk Statements  25-43
Safety Statements  22-36/37/39-45-36/37
RIDADR  2811
WGK Germany  WGK 3
Hazard Note  Irritant
HazardClass  6.1
PackingGroup  III
HS Code  2934999090
Storage Class 11 - Combustible Solids
Hazard Classifications Acute Tox. 4 Oral
Skin Sens. 1
Limited Quantities 5.0 kg (11 lbs) (solid)
Excepted Quantities Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L)
NFPA 704
1
3 0

THIOPHENE-2-THIOCARBOXAMIDE price More Price(72)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich CDS014286 Thiophene-2-carbothioamide AldrichCPR 20300-02-1 250 mg $77.9 2026-04-30 Buy
TCI Chemical T3604 Thiophene-2-carbothioamide >98.0%(HPLC) 20300-02-1 5g $403 2026-04-30 Buy
TCI Chemical T3604 Thiophene-2-carbothioamide >98.0%(HPLC) 20300-02-1 25g $1274 2026-04-30 Buy
Usbiological 290796 Thiophene-2-carbothioamide Asreported 20300-02-1 1g $375 2026-06-03 Buy
Usbiological 290796 Thiophene-2-carbothioamide Asreported 20300-02-1 2g $598 2026-06-03 Buy
Product number Packaging Price Buy
CDS014286 250 mg $77.9 Buy
T3604 5g $403 Buy
T3604 25g $1274 Buy
290796 1g $375 Buy
290796 2g $598 Buy

THIOPHENE-2-THIOCARBOXAMIDE Chemical Properties,Uses,Production

Uses

Thiophene-2-thiocarboxamide is used as a pharmaceutical intermediate.

Synthesis

2-THIOPHENECARBOXAMIDE

5813-89-8

THIOPHENE-2-THIOCARBOXAMIDE

20300-02-1

General procedure for the synthesis of thiophene-2-thioformamide from 2-thiophenecarboxamide: 2-thiophenecarboxamide (1 g, 7.86 mmol) was dissolved in dry 1,2-dimethoxyethane (30 mL). Lawesson's reagent (1.6 g, 3.9 mmol) was added and the reaction was protected under nitrogen. The reaction mixture was stirred at room temperature for 12 hours and then filtered. Subsequently, the solvent was removed by distillation under reduced pressure and the residue was purified by silica gel column chromatography (eluent: petroleum ether/ethyl acetate = 10:1 to 2:1) to afford thiophene-2-thiocarboxamide (1.0 g, 88.8% yield, white solid). Thiophene-2-carbothioamide can be used directly in the subsequent reaction without further purification.

References

[1] Patent: EP2708534, 2014, A1. Location in patent: Paragraph 0055
[2] ACS Medicinal Chemistry Letters, 2013, vol. 4, # 10, p. 904 - 908
[3] Journal of Medicinal Chemistry, 2017, vol. 60, # 17, p. 7512 - 7523
[4] Chemistry - A European Journal, 2013, vol. 19, # 29, p. 9655 - 9662
[5] Journal of Chemical Research, 2010, # 3, p. 151 - 153

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View Lastest Price from THIOPHENE-2-THIOCARBOXAMIDE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Thiophene-2-carbothioic acid amide   pictures 2025-12-12 Thiophene-2-carbothioic acid amide
20300-02-1
$1.00 1KG 99% 20 tons Shaanxi Dideu Medichem Co. Ltd
THIOPHENE-2-THIOCARBOXAMIDE pictures 2025-04-04 THIOPHENE-2-THIOCARBOXAMIDE
20300-02-1
1KG 98% 1ton Henan Aochuang Chemical Co.,Ltd.
Thiophene-2-thiocarboxamide pictures 2022-01-04 Thiophene-2-thiocarboxamide
20300-02-1
1g 98%minHPLC 50kgs/month Shanghai Rlavie Technology Co ltd

THIOPHENE-2-THIOCARBOXAMIDE Spectrum

OTAVA-BB BB7020331311 THIOPHENE-2-THIOAMIDE THIOPHENE-2-THIOCARBOXAMIDE THIOPHENE-2-CARBOTHIOIC ACID AMIDE Thiophene-2-carbothioamide, 95+% Thiophene-2-carbothioic acid amide, 2-Carbamothioylthiophene 2-(Aminothiocarbonyl)thiophene 2-Thienylthiocarboxamide 2-Thiocarbamoylthiophene 2-Thiophenecarbothioamide 2-Thiophenethiocarboxamide Thiophen-2-carbothioamide thiohypofluorous acid (4-oxo-3,4-dihydro-2H-1-benzopyran-6-yl) ester Thiophen-2-thiocarboxamid Thiophene-2-thiocarboxamide-97% THIOPHENE-2-CARBOTHIOAMIDE 20300-02-1
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