F16
- CAS No.
- 36098-33-6
- Chemical Name:
- F16
- Synonyms
- F16;RMA-297;F16 (F-16;Compound F16);F-16;COMPOUND F16;F16, 10 mM in DMSO;F16/Cell proliferation inhibitor (F16);4-[(E)-2-(INDOL-3-YL)ETHENYL]-N-METHYLPYRIDINIUM IODIDE;3-[2-(1-methylpyridin-1-ium-4-yl)ethenyl]-1H-indole,iodide;(E)-4-(2-(1H-Indol-3-yl)vinyl)-1-methylpyridin-1-ium iodide
- CBNumber:
- CB5739848
- Molecular Formula:
- C16H15IN2
- Molecular Weight:
- 362.21
- MDL Number:
- MFCD00050298
- MOL File:
- 36098-33-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| F16 ≥98% | 10022 | 1mg | $16 |
| F16 ≥98% | 10022 | 5mg | $59 |
| F16 ≥98% | 10022 | 10mg | $98 |
| F16 ≥98% | 10022 | 50mg | $423 |
| F16 ≥98% | 10022 | 1mg | $14 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H319-H335-H315 | |||||||||
| Precautionary statements | P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362 | |||||||||
| NFPA 704 |
|
F16 price More Price(38)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 10022 | F16 ≥98% | 36098-33-6 | 1mg | $16 | 2026-04-30 | Buy |
| Cayman Chemical | 10022 | F16 ≥98% | 36098-33-6 | 5mg | $59 | 2026-04-30 | Buy |
| Cayman Chemical | 10022 | F16 ≥98% | 36098-33-6 | 10mg | $98 | 2026-04-30 | Buy |
| Cayman Chemical | 10022 | F16 ≥98% | 36098-33-6 | 50mg | $423 | 2026-04-30 | Buy |
| Cayman Chemical | 10022 | F16 ≥98% | 36098-33-6 | 1mg | $14 | 2024-03-01 | Buy |
F16 Chemical Properties,Uses,Production
Uses
F16 is a cell-permeable mitochondrial toxin with apoptotic and necrotic action in tumor cell lines.
Biological Activity
f16 is a small, cationic, lipophilic, and fluorescent molecule capable of binding preferentially to mitochondrial membranes and disrupts their function. f16 is a potential antitumor agent.f16 affected growth in some mouse and human breast cancer cell lines. f16 resulted in a dramatic decrease in the number of cells in s phase and an increase in the percentage of cells in g1 phase [1]. prolonged incubation with 3 μm f16 led to increased cell death of f16-sensitive cells but not of f16-resistant ones. f16 accumulation in mitochondria induced mitochondrial damage characterized by imbalance of volumetric homeostasis, failure to synthesize atp, cytochrome c release and increased production of reactive oxy gen species [1]. f16 incubation decreased the cellular atp pool in both parental eph4-a6 and bcl-2-overexpressing eph4-a6.c13 and eph4-a6.c18 cells in a time-dependent manner [1]. treatment with f16 promoted early release of cytochrome c in transformed eph4-a6 cells. treatment with f16 (0.3-3 μm) resulted in the characteristic apoptotic dna laddering in the eph4-a6 cells. f16-induced mitochondrial dysfunction triggers apoptosis or necrosis. f16 induced necrosis in various cell lines resistant to apoptosis [2].
References
[1] fantin v r, berardi m j, scorrano l, et al. a novel mitochondriotoxic small molecule that selectively inhibits tumor cell growth[j]. cancer cell, 2002, 2(1): 29-42.
[2] fantin v r, leder p. f16, a mitochondriotoxic compound, triggers apoptosis or necrosis depending on the genetic background of the target carcinoma cell[j]. cancer research, 2004, 64(1): 329-336.
F16 Preparation Products And Raw materials
Raw materials
Preparation Products
F16 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32466 | 58 |
| CD Chemical Group Limited | +8615986615575 | info@codchem.com | China | 17259 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8467 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7552 | 61 |
| HangZhou YuHao Chemical Technology Co., Ltd. | 0571-82693216 | info@yuhaochemical.com | China | 2028 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 021-61312847; 18021002903 | 3008007409@qq.com | China | 89686 | 60 |
| Zhengzhou Acme Chemical Co., Ltd. | 0371-0371-55629727 13323845623 | 2885676761@qq.com | China | 10008 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 18892239720 | psaitong@jm-bio.com | China | 12306 | 58 |
| Beyond Pharmaceutical Co., Ltd | 0571-81953185 +86-15381198709 | jasonyao@bydpharma.com | China | 851 | 60 |
