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ChemicalBook >> CAS DataBase List >>ETHYL4-[2-(1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)ETHOXYL]-3-OXOBUTANOATE

ETHYL4-[2-(1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)ETHOXYL]-3-OXOBUTANOATE

CAS No.
88150-75-8
Chemical Name:
ETHYL4-[2-(1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)ETHOXYL]-3-OXOBUTANOATE
Synonyms
Ethyl 4-(2-(1,3-dioxoisoindolin-2-yl)ethoxy)-3-oxobutanoate;Amlodipine Impurity S;Amlodipine EP Impurity S;Amlodipine IH Impurity C;Benzeneethanol,β-amino-5-methoxy-;Ethyl-4(2-Phthalimido Ethoxy)Acetoacetate;4-(2-PhthaliMidoethoxy)acetoacetic Acid Ethyl Ester;Ethyl-4(2-phthalimido ethoxy)acetoacetate (AMB-Ester);Ethyl 4-[2-(1,3-dioxoisoindol-2-yl)ethoxy]-3-oxobutanoate;Ethyl 4-[2-(1,3-Dioxo-2-isoindolinyl)ethoxy]-3-oxobutanoate
CBNumber:
CB61236455
Molecular Formula:
C16H17NO6
Molecular Weight:
319.31
MDL Number:
MFCD12407176
MOL File:
88150-75-8.mol
Last updated:2026-05-28 02:10:17
Product description Number Pack Size Price
4-(2-Phthalimidoethoxy)acetoacetic Acid Ethyl Ester TRC-P384570-25MG 25mg $179
4-(2-Phthalimidoethoxy)acetoacetic Acid Ethyl Ester TRC-P384570-250MG 250mg $670
4-(2-Phthalimidoethoxy)acetoacetic Acid Ethyl Ester TRC-P384570-1G 1g $1321
Ethyl 4-(2-(1,3-dioxoisoindolin-2-yl)ethoxy)-3-oxobutanoate NDA15075 2g $900
Ethyl 4-(2-(1,3-dioxoisoindolin-2-yl)ethoxy)-3-oxobutanoate NDA15075 1g $900
More product size

ETHYL4-[2-(1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)ETHOXYL]-3-OXOBUTANOATE Properties

Boiling point 479.7±30.0 °C(Predicted)
Density 1.297±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility Chloroform (Slightly), DMSO (Sparingly), Methanol (Sparingly)
pka 9.83±0.46(Predicted)
form Oil
color Yellow

SAFETY

Risk and Safety Statements

ETHYL4-[2-(1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)ETHOXYL]-3-OXOBUTANOATE price More Price(47)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC TRC-P384570-25MG 4-(2-Phthalimidoethoxy)acetoacetic Acid Ethyl Ester 88150-75-8 25mg $179 2026-06-03 Buy
TRC TRC-P384570-250MG 4-(2-Phthalimidoethoxy)acetoacetic Acid Ethyl Ester 88150-75-8 250mg $670 2026-06-03 Buy
TRC TRC-P384570-1G 4-(2-Phthalimidoethoxy)acetoacetic Acid Ethyl Ester 88150-75-8 1g $1321 2026-06-03 Buy
Biosynth NDA15075 Ethyl 4-(2-(1,3-dioxoisoindolin-2-yl)ethoxy)-3-oxobutanoate 88150-75-8 2g $900 2026-06-04 Buy
Biosynth NDA15075 Ethyl 4-(2-(1,3-dioxoisoindolin-2-yl)ethoxy)-3-oxobutanoate 88150-75-8 1g $900 2026-06-04 Buy
Product number Packaging Price Buy
TRC-P384570-25MG 25mg $179 Buy
TRC-P384570-250MG 250mg $670 Buy
TRC-P384570-1G 1g $1321 Buy
NDA15075 2g $900 Buy
NDA15075 1g $900 Buy

ETHYL4-[2-(1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)ETHOXYL]-3-OXOBUTANOATE Chemical Properties,Uses,Production

Uses

4-(2-Phthalimidoethoxy)acetoacetic Acid Ethyl Ester is an intermediate in the synthesis of Amlodipine Besilate (A633500) related compounds.

Synthesis

N-Hydroxyethylphthalimide

3891-07-4

Ethyl 4-chloroacetoacetate

638-07-3

ETHYL4-[2-(1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)ETHOXYL]-3-OXOBUTANOATE

88150-75-8

a. Add 2400 mL of tetrahydrofuran to reaction flask A. Cool the mixture to -10°C or lower. Add 750 g of N-hydroxyethylphthalimide and 345 g of NaH sequentially (keep stirring at low speed during addition). Dropwise addition of ethyl 4-chloroacetoacetate was initiated within 30 minutes after addition of N-hydroxyethylphthalimide and NaH. The temperature of the reaction flask was maintained below -10 °C and 732 g of ethyl 4-chloroacetoacetate was slowly added dropwise, controlling the temperature below 0 °C. The dropwise process lasted for 1.5 to 2 hours. The temperature was then raised to 28 to 32 °C and the reaction was carried out for 5 to 6 hours. Upon completion of the reaction, 1500 mL of toluene was added and the temperature was lowered to below 5°C to obtain a toluene dilution of the reaction solution. b. In reaction flask B, 1700 mL of toluene, 2800 mL of water, and 1178 g of acetic acid were added and the temperature was maintained below 5°C. The toluene dilution of the reaction solution obtained in step a was slowly added to the reaction flask B at a temperature below 10°C. The addition process lasted from 1 to 1.5 hours. After stirring for 10 minutes, the mixture was allowed to stand for 15 minutes to separate and remove the aqueous layer. The toluene layer was washed five times with brine (2500 mL each time) with a mass fraction of 4%. Anhydrous magnesium sulfate was added to the washed toluene solution for drying, followed by concentration of the toluene solution under reduced pressure to remove toluene (not less than 2700 mL of toluene was removed, and the toluene content did not exceed a predetermined value) to ultimately obtain ethyl-4-(2-phthalimidoethoxy)acetoacetate in 93% yield.

References

[1] Patent: CN106749187, 2017, A. Location in patent: Paragraph 0031; 0032; 0033; 0034
[2] Patent: WO2004/58711, 2004, A1. Location in patent: Page 18, 19
[3] Patent: WO2005/16885, 2005, A2. Location in patent: Page/Page column 47-49
[4] Patent: WO2005/25507, 2005, A2. Location in patent: Page/Page column 166-167

ETHYL4-[2-(1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)ETHOXYL]-3-OXOBUTANOATE Preparation Products And Raw materials

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ETHYL4-[2-(1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)ETHOXYL]-3-OXOBUTANOATE pictures 2019-07-06 ETHYL4-[2-(1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)ETHOXYL]-3-OXOBUTANOATE
88150-75-8
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ETHYL4-[2-(1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)ETHOXYL]-3-OXOBUTANOATE Spectrum

ETHYL-4-(2-(PHTHALIMIDO)ETHOXY)ACETOACET ATE (MEIS S.NO.1122 & COUNTRY GROUP B) ETHYL4-[2-(1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)ETHOXYL]-3-OXOBUTANOATE Ethyl-4(2-Phthalimido Ethoxy)Acetoacetate 4-(2-PhthaliMidoethoxy)acetoacetic Acid Ethyl Ester Butanoic acid,4-[2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)ethoxy]-3-oxo-, ethyl ester Amlodipine IH Impurity C Amlodipine Impurity S Ethyl 4-[2-(1,3-Dioxo-2-isoindolinyl)ethoxy]-3-oxobutanoate Ethyl 4-[2-(1,3-dioxoisoindol-2-yl)ethoxy]-3-oxobutanoate ETHYL4-[2-(1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)ETHOXYL]-... Ethyl-4(2-phthalido) ethoxy aceto acetateQ: What is Ethyl-4(2-phthalido) ethoxy aceto acetate Q: What is the CAS Number of Ethyl-4(2-phthalido) ethoxy aceto acetate Q: What is the storage condition of Ethyl-4(2-phthalido) ethoxy aceto acetate Q: What are the applications of Ethyl-4(2-phthalido) ethoxy aceto acetate Ethyl-4(2-phthalimido ethoxy)acetoacetate (AMB-Ester) Benzeneethanol,β-amino-5-methoxy- Ethyl 4-[2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)ethoxy]-3-oxobutanoate Amlodipine EP Impurity S Ethyl-4(2-Phthalimido Ethoxy)Acetoacetate (Amlodipine intermediate) Ethyl 4-(2-(1,3-dioxoisoindolin-2-yl)ethoxy)-3-oxobutanoate 88150-75-8
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