ChemicalBook >> CAS DataBase List >>4-(4-Methylpiperazin-1-ylmethyl)benzoic acid
4-(4-Methylpiperazin-1-ylmethyl)benzoic acid
- CAS No.
- 106261-48-7
- Chemical Name:
- 4-(4-Methylpiperazin-1-ylmethyl)benzoic acid
- Synonyms
- Imatinib-int G;Imatinib Imp.S;Imatinib Impurity S;Imatinib Impurity 42;Imatinib Impurity 36;Imatinib impurities5;4-(4-Methyl-1-piperazinylmethyl)benzoicAci;4-(4-METHYLPIPERAZIN-1-YLMETHYL)BENZOIC ACID;4-(4-Methyl-1-piperazinylMethyl)benzoic Acid;4-(4-MethyIpiperazin-1-yImethyI)benzoic Acid
- CBNumber:
- CB61449907
- Molecular Formula:
- C13H18N2O2
- Molecular Weight:
- 234.29
- MDL Number:
- MFCD01632530
- MOL File:
- 106261-48-7.mol
- MSDS File:
- SDS
Last updated:2026-05-28 02:35:10
| Product description | Number | Pack Size | Price |
| 4-[(4-Methylpiperazin-1-yl)methyl]benzoic acid | FM136767 | 0.05kg | $900 |
| 4-[(4-Methylpiperazin-1-yl)methyl]benzoic acid | FM136767 | 0.025kg | $900 |
| 4-[(4-Methylpiperazin-1-yl)methyl]benzoic acid | FM136767 | 0.01kg | $900 |
| 4-[(4-Methylpiperazin-1-yl)methyl]benzoic acid | FM136767 | 0.005kg | $900 |
| 4-[(4-Methylpiperazin-1-yl)methyl]benzoic acid | FM136767 | 0.1kg | $1100 |
| More product size | |||
| Melting point | 310-312 °C |
|---|---|
| Boiling point | 377.2±32.0 °C(Predicted) |
| Density | 1.174±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| pka | 4.31±0.10(Predicted) |
| Appearance | White to off-white Solid |
| Water Solubility | Slightly soluble in water. |
| FDA UNII | M4XAX7UGT4 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| NFPA 704 |
|
4-(4-Methylpiperazin-1-ylmethyl)benzoic acid price More Price(65)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | FM136767 | 4-[(4-Methylpiperazin-1-yl)methyl]benzoic acid | 106261-48-7 | 0.05kg | $900 | 2026-06-04 | Buy |
| Biosynth | FM136767 | 4-[(4-Methylpiperazin-1-yl)methyl]benzoic acid | 106261-48-7 | 0.025kg | $900 | 2026-06-04 | Buy |
| Biosynth | FM136767 | 4-[(4-Methylpiperazin-1-yl)methyl]benzoic acid | 106261-48-7 | 0.01kg | $900 | 2026-06-04 | Buy |
| Biosynth | FM136767 | 4-[(4-Methylpiperazin-1-yl)methyl]benzoic acid | 106261-48-7 | 0.005kg | $900 | 2026-06-04 | Buy |
| Biosynth | FM136767 | 4-[(4-Methylpiperazin-1-yl)methyl]benzoic acid | 106261-48-7 | 0.1kg | $1100 | 2026-06-04 | Buy |
4-(4-Methylpiperazin-1-ylmethyl)benzoic acid Chemical Properties,Uses,Production
Uses
4-(4-Methyl-1-piperazinylmethyl)benzoic acid is used as Imatinib intermediate, as pharmaceutical intermediate.
Synthesis
728936-43-4
106261-48-7
GENERAL STEPS: Methyl 4-(4-methylpiperazin-1-ylmethyl)benzoate hydrochloride (1.25 g) was dissolved in potassium hydroxide-methanol solution (0.93 g KOH dissolved in 15 ml methanol). Water (0.75 ml) was added and the mixture was heated to reflux for 1 hour. After completion of the reaction, the mixture was cooled to room temperature and the pH was adjusted to 6 with 2 M hydrochloric acid solution. the solvent was removed by evaporation and the residue was dried under vacuum. The resulting residue contained 4-(4-methylpiperazin-1-ylmethyl)benzoic acid and the inorganic salt, which could be used in the subsequent reaction without further purification, assuming 100% yield of the title compound.1H NMR (400 MHz, d6-DMSO) δ: 2.27 (s, 3H), 2.44 (bs, 2H), 3.18-3.95 (m, 8H), 7.41 ( d, 2H, J=8Hz), 7.89 (d, 2H, J=8.1Hz).
References
[1] Patent: WO2004/63191, 2004, A1. Location in patent: Page 74
Synthesis of 4-(4-Methylpiperazin-1-ylmethyl)benzoic acid from 1-Methylpiperazine and 4-Formylbenzoic acid
4-(4-Methylpiperazin-1-ylmethyl)benzoic acid Preparation Products And Raw materials
Global( 196)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nanjing Fred Technology Co., Ltd | +86-25-84696168 +86-15380713688 | Austin@fredbio.com | China | 2428 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21585 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14332 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Shanghai Yingrui Biopharma Co.,Ltd | 21-33585366 | export01@shyrchem.com | CHINA | 1319 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29792 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
View Lastest Price from 4-(4-Methylpiperazin-1-ylmethyl)benzoic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-26 | 4-(4-Methylpiperazin-1-ylmethyl)benzoic acid
106261-48-7
|
1kg | 99%HPLC | 10tons | Nanjing Fred Technology Co., Ltd | ||
 |
2019-12-23 | 4-(4-Methylpiperazin-1-ylmethyl)benzoic acid
106261-48-7
|
$1.00 | 1KG | 99% | 100KG | Career Henan Chemical Co |
-
- 4-(4-Methylpiperazin-1-ylmethyl)benzoic acid
106261-48-7
- 99%HPLC
- Nanjing Fred Technology Co., Ltd
-
- 4-(4-Methylpiperazin-1-ylmethyl)benzoic acid
106261-48-7
- $1.00
- 99%
- Career Henan Chemical Co
106261-48-7(4-(4-Methylpiperazin-1-ylmethyl)benzoic acid)Related Search:
4-[(4-Methylpiperazin-1-yl)methyl]benzoic acid dihydrochloride
4-(Aminomethyl)benzoic acid
o-Toluic acid
4-(Chloromethyl)benzoic acid
2-(Trifluoromethyl)benzoic acid
m-Toluic acid
METHYL 4-[(4-METHYLPIPERAZIN-1-YL)METHYL]BENZOATE
p-Toluic acid
1-Methylpiperazine
2-(4-METHYLPIPERAZIN-1-YLMETHYL)BENZOIC ACID 95%,2-(4-METHYLPIPERAZIN-1-YLMETHYL)BENZOIC ACID
1of4
4-(4-METHYLPIPERAZIN-1-YLMETHYL)BENZOIC ACID
4-[(4-Methyl-1-piperaziny)methyl]benzoic acid dihydrochloride
Benzoic acid,4-[(4-methyl-1-piperazinyl)methyl]-
4-(4-Methyl-1-piperazinylMethyl)benzoic Acid
4-[(4-Methyl-1-piperaziny)Methyl]benzoic acid dihy
Imatinib Related Compound (4-(4-Methylpiperazin-1-yl)methyl)benzoic Acid)
4-[(1-methyl-2-piperazinyl)methyl]benzoic acid
Imatinib-int G
Imatinib Impurity 36
Imatinib Impurity 42
Imatinib Imp.S
4-(4-Methyl-1-piperazinylmethyl)benzoicacid,97%
4-(4-Methyl-1-piperazinylmethyl)benzoicAci
4-[(4-methylpiperazin-4-ium-1-yl)methyl]benzoate
Imatinib impurities5
4-((4-methylpiperazin-1-yl)methyl)benzoyl acid
4-(4-MethyIpiperazin-1-yImethyI)benzoic Acid
4-(4-Methylpiperazin-1-ylmethyl)benzoic acid, 98%min
Imatinib Impurity S
Imatinib Impurity: 4-(4-Methyl piperazinemethyl)benzoic acid dihydrochloride
106261-48-7
