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ChemicalBook >> CAS DataBase List >>4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid

4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid

CAS No.
641569-94-0
Chemical Name:
4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid
Synonyms
3-(4-(pyridin-3-yl)pyrimidin-2-ylamino)-4-methylbenzoic acid;-3-((4-(pyridin-3-yL;Nilotinib Impurity01;Nilotinib Intemediate 2;Nilotinib EP Impurity D;Nilotinib impurity D CRS;Nilotinib EP Impurity D/B;4-Methyl-3-((4-(pyridin-3-yl);Nilotinib Carboxylic Acid Impurity;Nilotinib Impurity 6 (Nilotinib EP Impurity D)
CBNumber:
CB61503982
Molecular Formula:
C17H14N4O2
Molecular Weight:
306.32
MDL Number:
MFCD11521324
MOL File:
641569-94-0.mol
MSDS File:
SDS
Last updated:2026-07-09 20:17:37
Product description Number Pack Size Price
4-methyl-3[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid Asreported 283156 50mg $337
4-methyl-3[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid Asreported 283156 100mg $468
4-methyl-3[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid Asreported 283156 250mg $612
4-methyl-3[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid Asreported 283156 500mg $758
4-methyl-3[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid Asreported 283156 1g $977
More product size

4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid Properties

Melting point >257oC (dec.)
Boiling point 587.9±60.0 °C(Predicted)
Density 1.336
storage temp. under inert gas (nitrogen or Argon) at 2–8 °C
solubility DMSO (Slightly), Methanol (Slightly, Heated)
pka 4.35±0.10(Predicted)
form Solid
color Pale Beige
Stability Hygroscopic
InChI InChI=1S/C17H14N4O2/c1-11-4-5-12(16(22)23)9-15(11)21-17-19-8-6-14(20-17)13-3-2-7-18-10-13/h2-10H,1H3,(H,22,23)(H,19,20,21)
InChIKey LDLZPHLSVKGFSC-UHFFFAOYSA-N
SMILES C(O)(=O)C1=CC=C(C)C(NC2=NC=CC(C3=CC=CN=C3)=N2)=C1
CAS DataBase Reference 641569-94-0(CAS DataBase Reference)
FDA UNII TQ9WCS4PF0

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302+H312+H332-H315-H319-H335
Precautionary statements  P261-P271-P280
HS Code  2933599590

4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid price More Price(72)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Usbiological 283156 4-methyl-3[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid Asreported 641569-94-0 50mg $337 2026-06-03 Buy
Usbiological 283156 4-methyl-3[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid Asreported 641569-94-0 100mg $468 2026-06-03 Buy
Usbiological 283156 4-methyl-3[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid Asreported 641569-94-0 250mg $612 2026-06-03 Buy
Usbiological 283156 4-methyl-3[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid Asreported 641569-94-0 500mg $758 2026-06-03 Buy
Usbiological 283156 4-methyl-3[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid Asreported 641569-94-0 1g $977 2026-06-03 Buy
Product number Packaging Price Buy
283156 50mg $337 Buy
283156 100mg $468 Buy
283156 250mg $612 Buy
283156 500mg $758 Buy
283156 1g $977 Buy

4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid Chemical Properties,Uses,Production

Chemical Properties

4-Methyl-3-[[4-(3-pyridyl)-2-pyrimidinyl]amino]benzoic acid is a yellow-white solid with a certain solubility in methanol and dimethyl sulfoxide.

Uses

4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid is used in the preparation of (pyridinyl)-N-[(triazolyl)phenyl]pyrimidinamine derivatives and (pyridinyl)-N-[oxadiazolyl)phenyl]pyrimidinamine derivatives, and can be used in the detection of their activity as antileukemia agents (neoplastic stem cell leukemia). 4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid is also a Nilotinib (N465300) intermediate, which might be useful in treatment of chronic myelogenous leukemia.

Synthesis

3- [(Aminoiminomethyl)amino] -4-methyl-benzoic acid methyl ester mononitrate (10 g),3-(Dimethylamino)-1-(pyridine-3-yl)prop-2-en-1-one (7.3 g), sodium hydroxide (1.7 g) was added to 1-butanol (100 mL) in a round bottom flask under nitrogen atmosphere. The reaction mass was heated to reflux temperature and stirred for 12 hours. Then the reaction mass was cooled to 25-35°C, and iN sodium hydroxide solution (1.5 g in 37 mL of DM water) was added to it throughout 20 mm. The reaction mass was heated to reflux temperature (120-125°C) and then cooled to 25-35°C. Hydrochloric acid was added to the reaction mass at 25-35°C and stirred for an hour. The material formed was filtered, washed with DM water and then dried under vacuum at 50-55°C to provide 4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid (8.7 g).

References

[1] Patent: WO2015/87343, 2015, A2. Location in patent: Page/Page column 15

2458-12-0
641569-94-0
Synthesis of 4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid from 3-Amino-4-methylbenzoic acid
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View Lastest Price from 4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid pictures 2026-07-10 4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid
641569-94-0
 1kg 98% 1000kgs Shaanxi Dideu New Materials Co. Ltd
4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid pictures 2026-07-09 4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid
641569-94-0
 $2.00-10.00 1KG 99% Henan Fengda Chemical Co., Ltd
4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid pictures 2026-02-28 4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid
641569-94-0
 1kg Purity: 99% 500tons Shandong Jihui Chemical Co., Ltd.

4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid Spectrum

4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid 4-Methyl-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}benzoic acid Benzoic acid, 4-Methyl-3-[[4-(3-pyridinyl)-2-pyriMidinyl]aMino]- 4-Methyl-3-[[4-(3-pyridinyl)-2-pyriMidiny]aMino]benzoic acid 2-[(5-Carboxy-2-methylphenyl)amino]-4-(pyridin-3-yl)pyrimidine, 3-{2-[(5-Carboxy-2-methylphenyl)amino]pyrimidin-4-yl}pyridine Nilotinib Intemediate 2 4-Methyl-3-((4-(pyridin-3-yl) Nilotinib EP Impurity D Nilotinib Carboxylic Acid Impurity -3-((4-(pyridin-3-yL 4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid(For export only) Nilotinib EP Impurity D/B 4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic aci... 4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]benzoicaci Nilotinib Impurity 6 (Nilotinib EP Impurity D) Nilotinib Hydrochloride Monohydrate EP Impurity D 4-Methyl-3-[[4-G-pyridinyl)-2-pyrimidinyl]amino] benzoic acid 4-Methyl-3-[[4-(3-pyridyl)-2-pyrimidinyl]amino]benzoicacid 4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidiryl]amino]benzoic acid Nilotinib Impurity01 Nilotinib Hydrochloride Monohydrate Impurity D Nilotinib impurity D CRS 3-(4-(pyridin-3-yl)pyrimidin-2-ylamino)-4-methylbenzoic acid 641569-94-0 641589-94-0
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