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ChemicalBook >> CAS DataBase List >>N-[(1S,2S)-3-(4-Chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methyl-2-[(5-(trifluoromethyl)pyridin-2-yl)oxy]propanamide( MK 0364)

N-[(1S,2S)-3-(4-Chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methyl-2-[(5-(trifluoromethyl)pyridin-2-yl)oxy]propanamide( MK 0364)

CAS No.
701977-09-5
Chemical Name:
N-[(1S,2S)-3-(4-Chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methyl-2-[(5-(trifluoromethyl)pyridin-2-yl)oxy]propanamide( MK 0364)
Synonyms
Taranabant;CS-782;MK 0364;Tranabant;Taranaban;Unii-X9U622S114;Taranabant [usan];Taranabant(MK 0364);Tranabant (MK-0364);N-((2S,3S)-4-(4-chlorophenyl)-3-(3-cyanophenyl)butan-2-yl)-2-Methyl-2-(pyridin-2-yloxy)propanaMide
CBNumber:
CB61562448
Molecular Formula:
C27H25ClF3N3O2
Molecular Weight:
515.95
MDL Number:
MFCD09970765
MOL File:
701977-09-5.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 03:54:27
Product description Number Pack Size Price
Taranabant ≥98% 10009795 500μg $54
Taranabant ≥98% 10009795 1mg $102
Taranabant ≥98% 10009795 5mg $418
Taranabant ≥98% 10009795 10mg $732
Taranabant ≥98% 10009795 500μg $49

N-[(1S,2S)-3-(4-Chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methyl-2-[(5-(trifluoromethyl)pyridin-2-yl)oxy]propanamide( MK 0364) Properties

Melting point 106.0-106.3 °C
Boiling point 634.2±55.0 °C(Predicted)
Density 1.30
storage temp. Store at -20°C
solubility DMSO: 50 mM
pka 14.55±0.46(Predicted)
form Powder
color White to off-white
FDA UNII X9U622S114

SAFETY

Risk and Safety Statements

Symbol(GHS)  Health Hazard (GHS08)Environment (GHS09)
GHS08,GHS09
Signal word  Danger
Hazard statements  H372-H400
Precautionary statements  P273-P391-P501-P260-P264-P270-P314-P501

N-[(1S,2S)-3-(4-Chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methyl-2-[(5-(trifluoromethyl)pyridin-2-yl)oxy]propanamide( MK 0364) price More Price(53)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 10009795 Taranabant ≥98% 701977-09-5 500μg $54 2026-04-30 Buy
Cayman Chemical 10009795 Taranabant ≥98% 701977-09-5 1mg $102 2026-04-30 Buy
Cayman Chemical 10009795 Taranabant ≥98% 701977-09-5 5mg $418 2026-04-30 Buy
Cayman Chemical 10009795 Taranabant ≥98% 701977-09-5 10mg $732 2026-04-30 Buy
Cayman Chemical 10009795 Taranabant ≥98% 701977-09-5 500μg $49 2024-03-01 Buy
Product number Packaging Price Buy
10009795 500μg $54 Buy
10009795 1mg $102 Buy
10009795 5mg $418 Buy
10009795 10mg $732 Buy
10009795 500μg $49 Buy

N-[(1S,2S)-3-(4-Chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methyl-2-[(5-(trifluoromethyl)pyridin-2-yl)oxy]propanamide( MK 0364) Chemical Properties,Uses,Production

Uses

Taranabant is a highly potent and selective cannabinoid 1 (CB1) receptor inverse agonist that inhibits the binding and functional activity of various agonists, with a binding Ki of 0.13 nM for the human CB1R in vitro.

Definition

ChEBI: Taranabant is a stilbenoid.

in vivo

Taranabant (MK-0364) dose-dependently inhibits 2 h and overnight food intake as well as overnight gains in body weight in C57BL/6N mice. At the 1- and 3-mg/kg doses (p.o.), Taranabant significantly inhibits 2-h food intake (36 and 69% reductions, respectively; P<0.05 and P<0.00001, respectively) and overnight food intake (13 and 40% reductions, respectively; P<0.05 and P<0.00001, respectively) as well as overnight gains in body weight (48 and 165% reductions, respectively; P<0.01 and P<0.00001, respectively). Taranabant dose-dependently inhibits food intake and weight gain, with an acute minimum effective dose of 1 mg/kg in diet-induced obese (DIO) rats[1]. Taranabant (MK-0364) has a good pharmacokinetic profile in three species (rat, 1 mg/kg iv, 2 mg/kg po, F=74%, t1/2=2.7 h; dog, 0.2 mg/kg iv, 0.4 mg/kg po, F=31%; t1/2=14 h; rhesus monkey, 0.2 mg/kg iv, 0.4 mg/kg po, F=31%, t1/2=3.6 h) and good brain exposure (1 mg/kg iv, brain and plasma concentrations of 0.11 and 0.18 μM at 1 h, respectively)[2].

References

[1] Fong TM, et al. Antiobesity Efficacy of a Novel Cannabinoid-1 Receptor Inverse Agonist, N-[(1S,2S)-3-(4-Chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2 -methyl-2-{[5-(trifluoromethyl)pyridin-2-yl]oxy}propanamide (MK-0364), in Rodents. J Pharmacol Exp T DOI:10.1124/jpet.106.118737
[2] Lin LS, et al. Discovery of N-[(1S,2S)-3-(4-Chlorophenyl)-2- (3-cyanophenyl)-1-methylpropyl]-2-methyl-2- {[5-(trifluoromethyl)pyridin-2-yl]oxy}propanamide (MK-0364), a novel, acyclic cannabinoid-1 receptor inverse agonist for the treatment of obesity. J M DOI:10.1021/jm060996+

N-[(1S,2S)-3-(4-Chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methyl-2-[(5-(trifluoromethyl)pyridin-2-yl)oxy]propanamide( MK 0364) Preparation Products And Raw materials

Raw materials

Preparation Products

N-[(1S,2S)-3-(4-Chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methyl-2-[(5-(trifluoromethyl)pyridin-2-yl)oxy]propanamide( MK 0364) Suppliers

Global( 55)Suppliers
Supplier Tel Email Country ProdList Advantage
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49979 58
TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354 marketing@targetmol.com United States 32466 58
ANHUI WITOP BIOTECH CO., LTD 		+8615255079626 eric@witopchemical.com China 23541 58
Shaanxi Dideu Medichem Co. Ltd 		+86-029-89586680 +86-18192503167 1026@dideu.com China 9996 58
Wuhan Nutra Biotechnology Co.,Ltd 		+8617786394783 nutrabiotech@outlook.com China 300 58
Baoji Guokang Healthchem Co., Ltd. 		+86-0917-3909592 +86-13892490616 gksales1@gk-bio.com China 9067 58
Hefei Hirisun Pharmatech Co., Ltd 		+8615056975894 shawn@hirisunpharm.com CHINA 9911 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
TargetMol Chemicals Inc. 		+1-781-999-5354; support@targetmol.com United States 39040 58
Aladdin Scientific 		tp@aladdinsci.com United States 52923 58

View Lastest Price from N-[(1S,2S)-3-(4-Chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methyl-2-[(5-(trifluoromethyl)pyridin-2-yl)oxy]propanamide( MK 0364) manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Taranabant pictures 2026-05-11 Taranabant
701977-09-5
 $99.00 99.06% 10g TargetMol Chemicals Inc.
Taranabant pictures 2026-05-11 Taranabant
701977-09-5
 $99.00 99.06% 10g TargetMol Chemicals Inc.
Taranabant pictures 2025-06-25 Taranabant
701977-09-5
 $1.10 1g 99.0% min 100 tons min Shaanxi Dideu Medichem Co. Ltd
  • Taranabant pictures
  • Taranabant
    701977-09-5
  • $99.00
  • 99.06%
  • TargetMol Chemicals Inc.
  • Taranabant pictures
  • Taranabant
    701977-09-5
  • $99.00
  • 99.06%
  • TargetMol Chemicals Inc.
  • Taranabant pictures
  • Taranabant
    701977-09-5
  • $1.10
  • 99.0% min
  • Shaanxi Dideu Medichem Co. Ltd
N-[(1S,2S)-3-(4-Chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methyl-2-[(5-(trifluoromethyl)pyridin-2-yl)oxy]propanamide( MK 0364) MK 0364 N-[(1S,2S)-3-(4-Chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methyl-2-[(5-(trifluoromethyl)pyridin-2-yl)oxy]propanamide Tranabant N-(3-(4-Chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl)-2-methyl-2-((5-(trifluoromethyl)pyridin-2-yl)oxy)propanamide Propanamide, N-((1S,2S)-3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl)-2-methyl-2-((5-(trifluoromethyl)-2-pyridinyl)oxy)- Taranabant [usan] Unii-X9U622S114 2S)-3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-Methylpropyl]-2-Methyl-2-[[5-(trifluoroMethyl)-2-pyridinyl]oxy]- N-((2S,3S)-4-(4-chlorophenyl)-3-(3-cyanophenyl)butan-2-yl)-2-Methyl-2-(pyridin-2-yloxy)propanaMide Taranabant(MK 0364) Tranabant (MK-0364) CS-782 Taranaban N-[(1S,2S)-3-(4-Chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methyl-2-[(5-(trifluoromethyl)pyridin-2-yl)oxy]propanamide( MK 0364) ISO 9001：2015 REACH Taranabant 701977-09-5 C27H25ClF3N3O2
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