ChemicalBook >> CAS DataBase List >>2-(TERT-BUTOXYCARBONYL)-1,2,3,4-TETRAHYDROISOQUINOLINE-6-CARBOXYLIC ACID

2-(TERT-BUTOXYCARBONYL)-1,2,3,4-TETRAHYDROISOQUINOLINE-6-CARBOXYLIC ACID

2-(TERT-BUTOXYCARBONYL)-1,2,3,4-TETRAHYDROISOQUINOLINE-6-CARBOXYLIC ACID structure

CAS No.: 170097-67-3

Chemical Name:: 2-(TERT-BUTOXYCARBONYL)-1,2,3,4-TETRAHYDROISOQUINOLINE-6-CARBOXYLIC ACID

Synonyms: Lifitegrast Impurity 45;N-BOC-6-HYDROXYCARBONYL-1,2,3,4-TETRAHYDRO;N-Boc-1,2,3,4-tetrahydroisoquinoline-6-carboxylic;2-Boc-1,2,3,4-Tetrahydroisoquinoline-6-Carboxylic Acid;N-BOC-1,2,3,4-TETRAHYDROISOQUINOLINE-6-CARBOXYLIC ACID;N-BOC-6-HYDROXYCARBONYL-1,2,3,4-TETRAHYDROISOQUINOLINE;2-(Tert-Butoxycarbonyl)-1,2,3,4-Tetrahydroisoquinoline-6-Car...;3,4-DIHYDRO-1H-ISOQUINOLINE-2,6-DICARBOXYLIC ACID 2-TERT-BUTYL ESTER;2-(TERT-BUTOXYCARBONYL)-1,2,3,4-TETRAHYDROISOQUINOLINE-6-CARBONIC ACID;2-(TERT-BUTOXYCARBONYL)-1,2,3,4-TETRAHYDROISOQUINOLINE-6-CARBOXYLIC ACID

CBNumber:: CB6238171

Molecular Formula:: C15H19NO4

Molecular Weight:: 277.32

MDL Number:: MFCD05861548

MOL File:: 170097-67-3.mol

MSDS File:: SDS

Last updated:2026-05-28 03:44:21

Product description	Number	Pack Size	Price
N-BOC-1,2,3,4-TETRAHYDROISOQUINOLINE-6-CARBOXYLIC ACID 97%	56192	1G	$131
N-BOC-1,2,3,4-TETRAHYDROISOQUINOLINE-6-CARBOXYLIC ACID 97%	56192	5G	$454
N-BOC-1,2,3,4-TETRAHYDROISOQUINOLINE-6-CARBOXYLIC ACID 97%	56192	25G	$2112
N-BOC-1,2,3,4-tetrahydroisoquinoline-6-carboxylic acid 97%	OR313034	100mg	$54
N-BOC-1,2,3,4-tetrahydroisoquinoline-6-carboxylic acid 97%	OR313034	250mg	$82
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Request For Quotation

2-(TERT-BUTOXYCARBONYL)-1,2,3,4-TETRAHYDROISOQUINOLINE-6-CARBOXYLIC ACID Properties

Boiling point	429.3±45.0 °C(Predicted)
Density	1+-.0.06 g/cm3(Predicted)
storage temp.	2-8°C
pka	4.33±0.20(Predicted)
Appearance	White to off-white Solid

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319
Precautionary statements	P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313
HS Code	2933992000

2-(TERT-BUTOXYCARBONYL)-1,2,3,4-TETRAHYDROISOQUINOLINE-6-CARBOXYLIC ACID price More Price(76)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
AstaTech	56192	N-BOC-1,2,3,4-TETRAHYDROISOQUINOLINE-6-CARBOXYLIC ACID 97%	170097-67-3	1G	$131	2026-04-30	Buy
AstaTech	56192	N-BOC-1,2,3,4-TETRAHYDROISOQUINOLINE-6-CARBOXYLIC ACID 97%	170097-67-3	5G	$454	2026-04-30	Buy
AstaTech	56192	N-BOC-1,2,3,4-TETRAHYDROISOQUINOLINE-6-CARBOXYLIC ACID 97%	170097-67-3	25G	$2112	2026-04-30	Buy
Apolloscientific	OR313034	N-BOC-1,2,3,4-tetrahydroisoquinoline-6-carboxylic acid 97%	170097-67-3	100mg	$54	2026-06-04	Buy
Apolloscientific	OR313034	N-BOC-1,2,3,4-tetrahydroisoquinoline-6-carboxylic acid 97%	170097-67-3	250mg	$82	2026-06-04	Buy

Product number	Packaging	Price	Buy
56192	1G	$131	Buy
56192	5G	$454	Buy
56192	25G	$2112	Buy
OR313034	100mg	$54	Buy
OR313034	250mg	$82	Buy

2-(TERT-BUTOXYCARBONYL)-1,2,3,4-TETRAHYDROISOQUINOLINE-6-CARBOXYLIC ACID Chemical Properties,Uses,Production

Uses

N-Boc-1,2,3,4-Tetrahydroisoquinoline-6-carboxylic Acid is the starting material used to prepare benzazole derivatives as β-secretase inhibitors useful in treatment and prevention of diseases.

Synthesis

2-TERT-BUTYL 6-METHYL 3,4-DIHYDROISOQUINOLINE-2,6(1H)-DICARBOXYLATE

170097-66-2

170097-67-3

Step 2: Synthesis of 2-(tert-butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-6-carboxylic acid; To a mixture of methanol/tetrahydrofuran (1:1, 6 mL) of the crude urethane obtained from Step 1 was added 1N sodium hydroxide solution (1.97 mL, 1.97 mmol). The reaction mixture was heated to 70 °C and maintained for 1 hour. After the reaction was completed, the mixture was cooled and methanol was removed by rotary evaporator. The remaining aqueous solution was acidified to pH 4 with 1 N hydrochloric acid.The resulting precipitate was collected by vacuum filtration and dried to give the target product (0.34 g, 93% yield), which could be used in subsequent reactions without further purification. Mass spectrum (electrospray positive ion mode) m/e 222.0 [M-tBu]+.

References

[1] Journal of Medicinal Chemistry, 2004, vol. 47, # 21, p. 5167 - 5182
[2] Patent: WO2009/49154, 2009, A1. Location in patent: Page/Page column 40
[3] Patent: EP3192791, 2017, A1. Location in patent: Paragraph 0596
[4] European Journal of Medicinal Chemistry, 2019, p. 317 - 333
[5] Patent: WO2006/114313, 2006, A1. Location in patent: Page/Page column 159

2-(TERT-BUTOXYCARBONYL)-1,2,3,4-TETRAHYDROISOQUINOLINE-6-CARBOXYLIC ACID Preparation Products And Raw materials

Raw materials

2-TERT-BUTYL 6-METHYL 3,4-DIHYDROISOQUINOLINE-2,6(1H)-DICARBOXYLATE Sodium hydroxide Tetrahydrofuran Water Methanol

Preparation Products

2-(TERT-BUTOXYCARBONYL)-1,2,3,4-TETRAHYDROISOQUINOLINE-6-CARBOXYLIC ACID Suppliers

Global( 107)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29640	60
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
Wuhan Chemwish Technology Co., Ltd	027-67849912	sales@chemwish.com	CHINA	10821	58
CONIER CHEM AND PHARMA LIMITED		sales@conier.com	China	49979	58
career henan chemical co	+86-0371-86658258	factory@coreychem.com	China	29792	58
SIMAGCHEM CORP	+86-5922680277 +86-13806087780	sale@simagchem.com	China	17346	58
Labnetwork lnc.	+86-27-50766799 +86-18062016861	contact@labnetwork.com	China	19987	58
Alfa Chemistry	+1-5166625404;	Info@alfa-chemistry.com	United States	20000	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418684 +86-18949823763	sales@tnjchem.com	China	25356	58
Changzhou AniKare Pharmatech Co., Ltd.	+86-0519-8359-8696	sales@anikare.com	China	10000	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
Alchem Pharmtech,Inc.	58
Wuhan Chemwish Technology Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
SIMAGCHEM CORP	58
Labnetwork lnc.	58
Alfa Chemistry	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
Changzhou AniKare Pharmatech Co., Ltd.	58

View Lastest Price from 2-(TERT-BUTOXYCARBONYL)-1,2,3,4-TETRAHYDROISOQUINOLINE-6-CARBOXYLIC ACID manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2020-01-10	2-[(2-methylpropan-2-yl)oxycarbonyl]-3,4-dihydro-1H-isoquinoline-6-carboxylic acid 170097-67-3	$5.50	1KG	98%min	1kg,10kg,100kg	Career Henan Chemical Co

2-[(2-methylpropan-2-yl)oxycarbonyl]-3,4-dihydro-1H-isoquinoline-6-carboxylic acid
170097-67-3
$5.50
98%min
Career Henan Chemical Co

2-(TERT-BUTOXYCARBONYL)-1,2,3,4-TETRAHYDROISOQUINOLINE-6-CARBOXYLIC ACID Spectrum

2-(TERT-BUTOXYCARBONYL)-1,2,3,4-TETRAHYDROISOQUINOLINE-6-CARBOXYLIC ACID(170097-67-3)¹HNMR 2-(TERT-BUTOXYCARBONYL)-1,2,3,4-TETRAHYDROISOQUINOLINE-6-CARBOXYLIC ACID(170097-67-3)¹HNMR

170097-67-3(2-(TERT-BUTOXYCARBONYL)-1,2,3,4-TETRAHYDROISOQUINOLINE-6-CARBOXYLIC ACID)Related Search:

5-BROMO-3,4-DIHYDRO-1H-ISOQUINOLINE-2-CARBOXYLIC ACID TERT-BUTYL ESTER TERT-BUTYL 5-HYDROXY-3,4-DIHYDROQUINOLINE-1(2H)-CARBOXYLATE 6-BROMO-3,4-DIHYDRO-1H-ISOQUINOLINE-2-CARBOXYLIC ACID TERT-BUTYL ESTER TERT-BUTYL 8-HYDROXY-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE TERT-BUTYL 6-HYDROXY-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE

TERT-BUTYL 8-BROMO-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE 2-Boc-1,2,3,4-Tetrahydroisoquinoline-5-Carboxylic Acid 2-Boc-1,2,3,4-Tetrahydroisoquinoline-8-Carboxylic Acid 2-(TERT-BUTOXYCARBONYL)-1,2,3,4-TETRAHYDROISOQUINOLINE-7-CARBOXYLIC ACID (S)-2-(tert-butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid,(3S)-2-(TERT-BUTOXYCARBONYL)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID

N-(TERT-BUTOXYCARBONYL)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID 2-TERT-BUTYL 6-METHYL 3,4-DIHYDROISOQUINOLINE-2,6(1H)-DICARBOXYLATE 3-(2-AMINOETHYL)BENZOIC ACID 4-[(tert-Butoxycarbonylamino)methyl]benzoic acid 2-(TERT-BUTOXYCARBONYL)-1,2,3,4-TETRAHYDROISOQUINOLINE-6-CARBOXYLIC ACID

TERT-BUTYL N-(4-FORMYLBENZYL)CARBAMATE 1,2,3,4-TETRAHYDROISOQUINOLINE 5,6,7,8-TETRAHYDROISOQUINOLINE

1of4

3,4-DIHYDRO-1H-ISOQUINOLINE-2,6-DICARBOXYLIC ACID 2-TERT-BUTYL ESTER 2-(TERT-BUTOXYCARBONYL)-1,2,3,4-TETRAHYDROISOQUINOLINE-6-CARBONIC ACID 2-(TERT-BUTOXYCARBONYL)-1,2,3,4-TETRAHYDROISOQUINOLINE-6-CARBOXYLIC ACID N-BOC-1,2,3,4-TETRAHYDROISOQUINOLINE-6-CARBOXYLIC ACID N-Boc-1,2,3,4-tetrahydroisoquinoline-6-carboxylic 2-Boc-1,2,3,4-Tetrahydroisoquinoline-6-Carboxylic Acid 2,6(1H)-Isoquinolinedicarboxylic acid, 3,4-dihydro-, 2-(1,1-dimethylethyl) ester N-BOC-6-HYDROXYCARBONYL-1,2,3,4-TETRAHYDROISOQUINOLINE N-BOC-6-HYDROXYCARBONYL-1,2,3,4-TETRAHYDRO 2-[(2-methylpropan-2-yl)oxycarbonyl]-3,4-dihydro-1H-isoquinoline-6-carboxylic acid 2-(Tert-Butoxycarbonyl)-1,2,3,4-Tetrahydroisoquinoline-6-Car... Lifitegrast Impurity 45 170097-67-3 pharmacetical

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