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ChemicalBook >> CAS DataBase List >>Cyclobenzaprine hydrochloride

Cyclobenzaprine hydrochloride

CAS No.
6202-23-9
Chemical Name:
Cyclobenzaprine hydrochloride
Synonyms
CYCLOBENZAPRINE HCL;flexeril;Flexiba;Lisseril;flexiban;Cyclobezaprine HCl;MK130 hydrochloride;Cyclobenzaprine HCI;Nortriptyline EP Impurity E;Amitriptyline EP Impurity B
CBNumber:
CB6238272
Molecular Formula:
C20H22ClN
Molecular Weight:
311.85
MDL Number:
MFCD00079039
MOL File:
6202-23-9.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 03:44:22
Product description Number Pack Size Price
Cyclobenzaprine hydrochloride C4542 1g $182
Cyclobenzaprine Hydrochloride certified reference material, pharmaceutical secondary standard PHR2797 400MG $326
Cyclobenzaprine hydrochloride European Pharmacopoeia (EP) Reference Standard C3200000 20 mg $175
Cyclobenzaprine hydrochloride solution 1.0?mg/mL in methanol (as free base), ampule of 1?mL, certified reference material, Cerilliant? C-060 1mL $40.8
Cyclobenzaprine hydrochloride British Pharmacopoeia (BP) Reference Standard BP886 25 mg $229
More product size

Cyclobenzaprine hydrochloride Properties

Melting point 216-2180C
Flash point 9℃
storage temp. Inert atmosphere,Room Temperature
Water Solubility Completely soluble in water
solubility ≥15.59 mg/mL in DMSO; ≥5.32 mg/mL in EtOH; ≥54.3 mg/mL in H2O
form Solid
color White to Almost white
λmax 290nm(lit.)
Merck 14,2713
Major Application pharmaceutical (small molecule)
InChI 1S/C20H21N.ClH/c1-21(2)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20;/h3-6,8-14H,7,15H2,1-2H3;1H
InChIKey VXEAYBOGHINOKW-UHFFFAOYSA-N
SMILES Cl.CN(C)CC\C=C1\c2ccccc2C=Cc3ccccc13
CAS DataBase Reference 6202-23-9(CAS DataBase Reference)
FDA UNII 0VE05JYS2P
NCI Drug Dictionary cyclobenzaprine hydrochloride
UNSPSC Code 41116107
NACRES NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)  Skull and Crossbones (GHS06)
GHS06
Signal word  Danger
Hazard statements  H301-H312+H332
Precautionary statements  P280-P301+P310+P330-P302+P352+P312-P304+P340+P312
Hazard Codes  Xn,T,F
Risk Statements  20/21/22-39/23/24/25-23/24/25-11
Safety Statements  36-45-36/37-16-7
RIDADR  UN 2811 6.1/PG 3
WGK Germany  3
RTECS  HP0875000
HazardClass  6.1(b)
PackingGroup  III
HS Code  29214990
Storage Class 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects
Hazard Classifications Acute Tox. 3 Oral
Acute Tox. 4 Dermal
Acute Tox. 4 Inhalation
Toxicity LD50 in mice (mg/kg): 35 i.v., 250 orally (Metysova)
NFPA 704
3
0 0

Cyclobenzaprine hydrochloride price More Price(82)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich C4542 Cyclobenzaprine hydrochloride 6202-23-9 1g $182 2026-04-30 Buy
Sigma-Aldrich PHR2797 Cyclobenzaprine Hydrochloride certified reference material, pharmaceutical secondary standard 6202-23-9 400MG $326 2026-04-30 Buy
Sigma-Aldrich C3200000 Cyclobenzaprine hydrochloride European Pharmacopoeia (EP) Reference Standard 6202-23-9 20 mg $175 2026-04-30 Buy
Sigma-Aldrich C-060 Cyclobenzaprine hydrochloride solution 1.0?mg/mL in methanol (as free base), ampule of 1?mL, certified reference material, Cerilliant? 6202-23-9 1mL $40.8 2026-04-30 Buy
Sigma-Aldrich BP886 Cyclobenzaprine hydrochloride British Pharmacopoeia (BP) Reference Standard 6202-23-9 25 mg $229 2026-04-30 Buy
Product number Packaging Price Buy
C4542 1g $182 Buy
PHR2797 400MG $326 Buy
C3200000 20 mg $175 Buy
C-060 1mL $40.8 Buy
BP886 25 mg $229 Buy

Cyclobenzaprine hydrochloride Chemical Properties,Uses,Production

Description

Cyclobenzaprine is a skeletal muscle relaxant that also has sedative properties. It has been shown to antagonize muscarinic receptors (Kis = 25, 60, and 6 nM for M1, M2, and M3, respectively), serotonin 5-HT2 receptors (Kis = 56 and 330 nM for 5-HT2C and 5-HT2B, respectively), and histamine H1 receptor (IC50 = 20 nM).

Chemical Properties

Crystalline Solid

Originator

Flexeril,Merck Sharp andDohme,US,1977

Uses

Cyclobenzaprine hydrochloride has been used to study its effect on the muscles of dystrophin-deficient mdx5Cv mice.

Uses

Cyclobenzaprine hydrochloride can be used as a serotonin receptor inhibitor.

Uses

Cyclobenzaprine hydrochloride cam be used as muscle relaxant (skeletal).

Definition

ChEBI: The hydrochloride salt of cyclobenzaprine. A centrally acting skeletal muscle relaxant, it is used in the symptomatic treatment of painful muscle spasm.

Manufacturing Process

In an initial step, dibenzo [a,d]cyclohepten-5-one is reacted with the Grignardreagent of 3-dimethylaminopropyl chloride and hydrolyzed to give 5-(3-dimethylaminopropyl)-dibenzo[a,d][1,4]cycloheptatriene-5-ol. Then 13 g ofthat material, 40 ml of hydrochloric acid, and 135 ml of glacial acetic acid isrefluxed for 3 hours. The solution is then evaporated to dryness in vacuoand added to ice water which is then rendered basic by addition of ammoniumhydroxide solution. Extraction of the basic solution with chloroform andremoval of the solvent from the dried chloroform extracts yields the crudeproduct which when distilled in vacuo yields essentially pure 5-(3-dimethylaminopropylidene)-dibenzo[a,d][1,4]cycloheptatriene, BP 173°C to177°C at 1.0 mm.

brand name

Flexeril (McNeil).

Therapeutic Function

Muscle relaxant

General Description

Cyclobenzaprine is a tricyclic agent, which has anti-depressant and anti-cholinergic properties. It lowers the tonic somatic motor activity of motor neuron systems. Cyclobenzaprine prevents the uptake ofnoradrenaline. It is used to treat neck,back and myofascial pain. Cyclobenzaprine functions as a nerve impulse inhibitor.

References

[1]. honda m, nishida t, ono h. tricyclic analogs cyclobenzaprine, amitriptyline and cyproheptadine inhibit the spinal reflex transmission through 5-ht2 receptors. european journal of pharmacology, 2003, 458(1): 91-99.
[2]. barnes c d, fung s j, gintautas j. brainstem noradrenergic system depression by cyclobenzaprine. neuropharmacology, 1980, 19(2): 221-224.
[3]. leysen j e. 5-ht2 receptors. current drug targets-cns & neurological disorders, 2004, 3(1): 11-26.

Cyclobenzaprine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 353)Suppliers
Supplier Tel Email Country ProdList Advantage
Shaanxi Dideu Medichem Co. Ltd 		+86-29-87569262 +86-15003564040 1056@dideu.com China 3969 58
Guangzhou Tengyue Chemical Co., Ltd. 		+86-86-18148706580 +86-18826483838 evan@tyvovo.com China 143 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718 +86-13336195806 sales@capot.com China 29640 60
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Shanghai Arbor Chemical Co., Ltd. 		021-60451682 act@arborchemical.com CHINA 904 58
CONIER CHEM AND PHARMA LIMITED 		sales@conier.com China 49979 58
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View Lastest Price from Cyclobenzaprine hydrochloride manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Cyclobenzaprine hydrochloride pictures 2026-06-30 Cyclobenzaprine hydrochloride
6202-23-9
 1kg 98% 10000KGS Shaanxi Dideu New Materials Co. Ltd
Cyclobenzaprine hydrochloride pictures 2026-02-02 Cyclobenzaprine hydrochloride
6202-23-9
 1KG 99% 2000tons Shaanxi Dideu Medichem Co. Ltd
Cyclobenzaprine hydrochloride pictures 2025-04-21 Cyclobenzaprine hydrochloride
6202-23-9
 $90.00 1kg 99% Purity (What/sapp: +86 18145728414) 1000 Tons/Month Guangzhou Tengyue Chemical Co., Ltd.

Cyclobenzaprine hydrochloride Spectrum

3-(5h-dibenzo(a,d)cyclohepten-5-ylidene)-n,n-dimethyl-1-propanaminhydroc 5-(3-dimethylaminopropylidene)-5h-dibenzo-(a,d)cycloheptenehydrochloride CYCLOBENZAPRINEHYDROCHLORIDE,USP Lisseril Proheptatriene hydrochloride Cyclobenzaprine hydrochloride,5-(3-Dimethylaminopropylidene)dibenzo[a,e]cycloheptatriene hydrochloride Cyclobenzaprine Hydrochloride (200 mg) 3-(5H-Dibenzo[a,d][7]annulen-5-ylidene)-N,N-dimethylpropan-1-amine hydrochloride 1-PropanaMine,3-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-diMethyl-, hydrochloride (1:1) 3-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-1-propanamine, hydrochloride (1:1) Cyclobenzaprine hydrochloride solution d)cycloheptene-delta(sup5)-gamma-propylamine,n,n-dimethyl-5h-dibenzo(hydr flexiban n,n-dimethyl-5h-dibenzo(a,d)cycloheptene-delta(sup5,gamma)-propylaminehydro proheptatrienmonohydrochloride CYCLOBENZAPRINE HYDROCHLORIDE AMITRITYLINE HYDROCHLORIDE IMP B 5-[3-DIMETHYLAMINOPROPYLIDENE]-DIBENZO[A,E]CYCLOHEPTATRIENE HYDROCHLORIDE 3-(5H-dibenzo[a,d]cyclohepten-5-ylidene)propyl(dimethyl)ammonium chloride 3-(5H-Dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-1-propanamine Hydrochloride Flexiba 1-Propanamine, 3-(5H-dibenzoa,dcyclohepten-5-ylidene)-N,N-dimethyl-, hydrochloride Nortriptyline EP Impurity E Amitriptyline EP Impurity B HCl Cyclobenzaprine hydrochloride, 98%, a peripherally-acting AAAD or DOPA decarboxylase inhibitor Cyclobenzaprine Hydrochloride, Usp 99% Amitriptyline hydrochloride impurity B Cyclobenzaprine Hydrochloride(Flexeril,Yurelax) Amitriptyline EP Impurity B Cyclobenzaprine hydrochloride CRS Cyclobenzaprine Hydrochloride > Amitriptyline EP Impurity B HCl (Nortriptyline EP Impurity E HCl) Cyclobezaprine HCl Amitriptyline EP Impurity B (Cyclobenzaprine) Cyclobenzaprine HCl (MK130) Cyclobenzaprine HydrochlorideQ: What is Cyclobenzaprine Hydrochloride Q: What is the CAS Number of Cyclobenzaprine Hydrochloride Q: What is the storage condition of Cyclobenzaprine Hydrochloride Q: What are the applications of Cyclobenzaprine Hydrochloride Cyclobenzaprine Hydrochloride (1154503) Cyclobenzaprine (hydrochloride) (CRM) Hydrochloride Cyclobenzaprine MK130 hydrochloride CYCLOBENZAPRINE HCL RSSYY(Perospirone Hydrochloride Hydrate)-1 Amitriptyline Hydrochloride EP Impurity B as Hydrochloride Nortriptyline Hydrochloride EP Impurity E as Hydrochloride Nortriptyline Hydrochloride Impurity E as Hydrochloride Nortriptyline EP Impurity E HCl Nortriptyline EP Impurity E HCl (Amitriptyline EP Impurity B HCl) Cyclobenzaprine hydrochloride in methanol Nortriptyline EP Impurity E (hydrochloride) 3-(5H-Dibenzo[a,d][7]annulen-5-ylidene)-N,N-dimethylpropan-1-amine Hydrochloride (Cyclobenzaprine Hy Cyclobenzaprine hydrochloride, 10 mM in DMSO Cyclobenzaprine HCI Cyclobenzaprine Hydrochloride 1.0 mg/ml in Methanol (as free base) Cyclobenzaprine.HCl, 1mg/ml in Methanol (as free base) 3-(5H-Dibenzo[a,d][7]annulen-5-ylidene)-N,N-dimethylpropan-1-amine Hydrochloride (Cyclobenzaprine Hydrochloride) 2,4-Dichloro-3,5-dinitroanisole Cyclobenzaprine HCl (Nortriptyline EP Impurity E HCl, Amitriptyline EP Impurity B HCl) Amitriptyline Hydrochloride Impurity B as Hydrochloride
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