METHYLSTAT
- CAS No.
- 1310877-95-2
- Chemical Name:
- METHYLSTAT
- Synonyms
- METHYLSTAT;Methylstat >=98% (HPLC);MUJOCHRZXRZONW-FOCLMDBBSA-N;JMJD Histone Demethylase Inhibitor IV, Methylstat;Methylstat, jumonji C domain-containing histone demethylase inhibitor;JMJD Histone Demethylase Inhibitor IV, Methylstat - CAS 1310877-95-2 - Calbiochem;(E)-methyl 4-(N-hydroxy-4-(4-((naphthalen-1-yl-carbamoyloxy)methyl)benzylamino)butylamino)-4-oxobut-2-enoate;(2E)-4-[Hydroxy[4-[[[4-[[[(1-naphthalenylamino)carbonyl]oxy]methyl]phenyl]methyl]amino]butyl]amino]-4-oxo-2-butenoic acid methyl ester;2-Butenoic acid, 4-[hydroxy[4-[[[4-[[[(1-naphthalenylamino)carbonyl]oxy]methyl]phenyl]methyl]amino]butyl]amino]-4-oxo-, methyl ester, (2E)-
- CBNumber:
- CB62628129
- Molecular Formula:
- C28H31N3O6
- Molecular Weight:
- 505.56
- MDL Number:
- MFCD22572723
- MOL File:
- 1310877-95-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Methylstat ≥98% (HPLC) | SML0343 | 5mg | $228 |
| JMJD Histone Demethylase Inhibitor IV, Methylstat | 420203 | 10mg | $335 |
| JMJD Histone Demethylase Inhibitor IV, Methylstat ((E)-Methyl-4-(hydroxy(4-((4-(((naphthalen-1-ylcarbamoyl)oxy)methyl)benzyl)amino)butyl)amino)-4-oxobut-2-enoate, Histone Lysine Demethylase Inhibitor VII, Methylstat) ≥96%(HPLC) | 217483 | 10mg | $596 |
| JMJD Histone Demethylase Inhibitor IV, Methylstat | KCC87795 | 25mg | $1241.25 |
| JMJD Histone Demethylase Inhibitor IV, Methylstat | KCC87795 | 50mg | $1727 |
METHYLSTAT price More Price(24)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0343 | Methylstat ≥98% (HPLC) | 1310877-95-2 | 5mg | $228 | 2026-04-30 | Buy |
| Sigma-Aldrich | 420203 | JMJD Histone Demethylase Inhibitor IV, Methylstat | 1310877-95-2 | 10mg | $335 | 2023-01-07 | Buy |
| Usbiological | 217483 | JMJD Histone Demethylase Inhibitor IV, Methylstat ((E)-Methyl-4-(hydroxy(4-((4-(((naphthalen-1-ylcarbamoyl)oxy)methyl)benzyl)amino)butyl)amino)-4-oxobut-2-enoate, Histone Lysine Demethylase Inhibitor VII, Methylstat) ≥96%(HPLC) | 1310877-95-2 | 10mg | $596 | 2026-06-03 | Buy |
| Biosynth | KCC87795 | JMJD Histone Demethylase Inhibitor IV, Methylstat | 1310877-95-2 | 25mg | $1241.25 | 2026-06-04 | Buy |
| Biosynth | KCC87795 | JMJD Histone Demethylase Inhibitor IV, Methylstat | 1310877-95-2 | 50mg | $1727 | 2026-06-04 | Buy |
METHYLSTAT Chemical Properties,Uses,Production
Uses
Methylstat is a potent histone demethylases inhibitor. Methylstat shows anti-proliferative activity with low cytotoxicity. Methylstat induces apoptosis and cell cycle arrest at G0/G1 phase. Methylstat increases the expression of p53 and p21 protein levels. Methylstat inhibits angiogenesis induced by various cytokines. Methylstat can be used as a chemical probe for addressing its role in angiogenesis[1][2].
Definition
ChEBI: 4-[hydroxy-[4-[[4-[[(1-naphthalenylamino)-oxomethoxy]methyl]phenyl]methylamino]butyl]amino]-4-oxo-2-butenoic acid methyl ester is a member of naphthalenes.
Biological Activity
Methylst at is an inhibitor of the Jumonji C domain-containing histone trimethyl demethylases (JHDMs). Methylst at inhibits the activity of JMJD2C (IC50 = 4.3 μM), with similar potency against JMJD2E and JMJD3. The compound has poor activity against dimethyl demethylases, and does not inhibit class I or II HDACs. Methyls at blocks proliferation of the esophageal carcinoma cell line KYSE150 with an IC50 value of 5.1 μM.
References
[1] Yumi Cho, et al. A histone demethylase inhibitor, methylstat, inhibits angiogenesis in vitro and in vivo. RSC Advances, 2014.
[2] Kac FN, et al. Synergistic Apoptotic Effects of Bortezomib and Methylstat on Multiple Myeloma Cells. Arch Med Res. 2020 Apr;51(3):187-193. DOI:10.1016/j.arcmed.2020.01.012
METHYLSTAT Preparation Products And Raw materials
Raw materials
Preparation Products
METHYLSTAT Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19936 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32466 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39037 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52923 | 58 | |
| Beijing Yisiyan Technology Research Center | 010-56645598 13366904824 | bjkaida@163.com | China | 1600 | 59 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing@energy-chemical.com | China | 44918 | 58 |
| Beijing Biocreative Technology Co., Ltd. | 15522676233 | 3007606172@qq.com | China | 1248 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24959 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11972 | 58 |
| Huai Hua Binfengchem Co., Ltd | 0745-2866851 17711757908 | 406037272@qq.com | China | 4630 | 58 |
View Lastest Price from METHYLSTAT manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-15 | Methylstat
1310877-95-2
|
$199.00 | 98.34% | 10g | TargetMol Chemicals Inc. |
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- Methylstat
1310877-95-2
- $199.00
- 98.34%
- TargetMol Chemicals Inc.
