3-ISOBUTYL-1-METHYLXANTHINE
- CAS No.
- 28822-58-4
- Chemical Name:
- 3-ISOBUTYL-1-METHYLXANTHINE
- Synonyms
- IBMX;MIX;IMX;3-Isobutyl-1-methyl-3,7-dihydro-1H-purine-2,6-dione;SC 2964;I5879-1G;NSC 165960;I5879-100MG;I5879-250MG;IBMX(NSC165960
- CBNumber:
- CB6263892
- Molecular Formula:
- C10H14N4O2
- Molecular Weight:
- 222.24
- MDL Number:
- MFCD00005584
- MOL File:
- 28822-58-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 3-Isobutyl-1-methylxanthine | 410957 | 250mg | $94 |
| 3-Isobutyl-1-methylxanthine - CAS 28822-58-4 - Calbiochem A cell-permeable, non-specific inhibitor of cAMP and cGMP phosphodiesterases (IC?? = 2-50 μM). | 410957 | 1g | $253 |
| IBMX ≥98% | 13347 | 100mg | $43 |
| IBMX ≥98% | 13347 | 250mg | $81 |
| IBMX ≥98% | 13347 | 500mg | $140 |
| More product size | |||
| Melting point | 200-201 °C(lit.) |
|---|---|
| Boiling point | 363.42°C (rough estimate) |
| Density | 1.2042 (rough estimate) |
| refractive index | 1.6500 (estimate) |
| storage temp. | -20°C |
| solubility | DMSO: 1 M with gentle warming |
| form | powder |
| pka | 8.61±0.70(Predicted) |
| color | off-white |
| BRN | 247859 |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. |
| InChI | InChI=1S/C10H14N4O2/c1-6(2)4-14-8-7(11-5-12-8)9(15)13(3)10(14)16/h5-6H,4H2,1-3H3,(H,11,12) |
| InChIKey | APIXJSLKIYYUKG-UHFFFAOYSA-N |
| SMILES | N1C2=C(N(CC(C)C)C(=O)N(C)C2=O)NC=1 |
| CAS DataBase Reference | 28822-58-4(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | TBT296U68M |
| UNSPSC Code | 12352202 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P264-P270-P301+P312a-P330-P501a | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Faceshields, Gloves | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22 | |||||||||
| Safety Statements | 24/25 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | ZD8500000 | |||||||||
| HS Code | 29335990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
3-ISOBUTYL-1-METHYLXANTHINE price More Price(108)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 410957 | 3-Isobutyl-1-methylxanthine | 28822-58-4 | 250mg | $94 | 2026-04-30 | Buy |
| Sigma-Aldrich | 410957 | 3-Isobutyl-1-methylxanthine - CAS 28822-58-4 - Calbiochem A cell-permeable, non-specific inhibitor of cAMP and cGMP phosphodiesterases (IC?? = 2-50 μM). | 28822-58-4 | 1g | $253 | 2026-04-30 | Buy |
| Cayman Chemical | 13347 | IBMX ≥98% | 28822-58-4 | 100mg | $43 | 2026-04-30 | Buy |
| Cayman Chemical | 13347 | IBMX ≥98% | 28822-58-4 | 250mg | $81 | 2026-04-30 | Buy |
| Cayman Chemical | 13347 | IBMX ≥98% | 28822-58-4 | 500mg | $140 | 2026-04-30 | Buy |
3-ISOBUTYL-1-METHYLXANTHINE Chemical Properties,Uses,Production
Description
IBMX (28822-58-4) is a pan-specific inhibitor of phosphodiesterases (IC50=2-50 μM). Inhibition of PDEs leads to increased concentration of intracellular cAMP which activates PKA.2IBMX does not inhibit PDE8 or PDE9.3Weak adenosine receptor antagonist.4
Chemical Properties
White Needles with Yellow Cast
Uses
phosphodiesterase inhibitor
Uses
A nonspecific inhibitor of phosphodiesterases
Uses
3-Isobutyl-1-methylxanthine is used in inhibition of phenylephrine-induced release of 5-hydroxytryptamine from neuroendocrine epithelial cells of the airway mucosa (IC50 = 1.3 uM). Also inhibits ion channels in the neuromuscular junction, GH3 cells, and vascular smooth muscle cells. Inhibits the growth of carcinoma cells both in vivo and in vitro in mice.
Definition
ChEBI: 3-isobutyl-1-methyl-9H-xanthine is a 3-isobutyl-1-methylxanthine. It is functionally related to a 9H-xanthine. It is a tautomer of a 3-isobutyl-1-methyl-7H-xanthine.
General Description
3-isobutyl-1-methylxanthine/IBMX is a non-selective, non-specific inhibitor of cAMP and cGMP phosphodiesterases. IBMX can induce melanogenesis, and can be used as a positive control in melanogenesis research. In oocyte research, IBMX assists in maintaining the germinal vesicle (GV) arrest of prophase I oocytes.
Biological Activity
Phosphodiesterase inhibitor (IC 50 values are 13, 18, 19, 32 and 50 μ M for PDE4, PDE3, PDE1, PDE5 and PDE2 respectively). Suppresses α -adrenoceptor-mediated 5-HT release from neuroendocrine epithelial cells (IC 50 = 1.3 μ M).
Biochem/physiol Actions
The increase in cAMP level as a result of phosphodiesterase inhibition by IBMX activates PKA, leading to decreased proliferation, increased differentiation, and induction of apoptosis. IBMX inhibits phenylephrine-induced release of 5-hydroxytryptamine from neuroendocrine epithelial cells of the airway mucosa (IC50: 1.3 μM). IBMX also serves as an adenosine receptor antagonist. IBMX has been shown to inhibit ion channels in the neuromuscular junction, GH3 cells, and vascular smooth muscle cells. IBMX induces calcium release from intracellular stores in sensory neurons.
storage
+4°C
Purification Methods
Recrystallise it from aqueous EtOH. [Beilstein 26
Background
3-isobutyl-1-methylxanthine is a nonselective inhibitor of cAMP and cGMP phosphodiesterases. Research studies show that IBMX inhibits many members of the PDE family, with the exceptions of PDE8A, PDE8B, and PDE9. Treatment of cells with IBMX promotes accumulation of cAMP and cGMP, which leads to activation of cyclic-nucleotide-regulated protein kinases. Additional research indicates that IBMX can promote neuronal progenitor cell maturation in vitro.
References
[1] J A BEAVO. Effects of xanthine derivatives on lipolysis and on adenosine 3’,5’-monophosphate phosphodiesterase activity.[J]. Molecular Pharmacology, 1970, 6 6: 597-603.
[2] CLAUDIA TOMES Silvia M Silvia Rossi. Isobutylmethylxanthine and other classical cyclic nucleotide phosphodiesterase inhibitors affect cAMP-dependent protein kinase activity[J]. Cellular signalling, 1993, 5 5: Pages 615-621. DOI:10.1016/0898-6568(93)90056-r
[3] SCOTT H SODERLING Joseph A B. Regulation of cAMP and cGMP signaling: new phosphodiesterases and new functions[J]. Current Opinion in Cell Biology, 2000, 12 2: Pages 174-179. DOI:10.1016/s0955-0674(99)00073-3
[4] J W DALY D U K A Jacobson. Adenosine receptors: development of selective agonists and antagonists.[J]. Progress in clinical and biological research, 1987, 230: 41-63.
3-ISOBUTYL-1-METHYLXANTHINE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29812 | 58 |
| Nanjing Baifuli Technology Co., Ltd. | +86-15335185688 | sales@unisyn.cn | CHINA | 332 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | sales@conier.com | China | 49979 | 58 | |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32468 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +86-189 4982 3763 | sales@tnjchem.com | China | 34563 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8618071025641 | eric@witopchemical.com | China | 23541 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1059@dideu.com | China | 29120 | 58 |
| AFINE CHEMICALS LIMITED | +86-571-85134551 +86-18958018566 | info@afinechem.com | China | 15079 | 58 |
View Lastest Price from 3-ISOBUTYL-1-METHYLXANTHINE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-17 | IBMX
28822-58-4
|
$33.00-58.00 | 99.79% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-06-30 | 3-ISOBUTYL-1-METHYLXANTHINE
28822-58-4
|
1kg | 98% | 1000 | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2019-07-06 | 3-ISOBUTYL-1-METHYLXANTHINE
28822-58-4
|
$8.00 | 1kg | 99% | 10tons | Career Henan Chemical Co |
-
- IBMX
28822-58-4
- $33.00-58.00
- 99.79%
- TargetMol Chemicals Inc.
-
- 3-ISOBUTYL-1-METHYLXANTHINE
28822-58-4
- 98%
- Shaanxi Dideu New Materials Co. Ltd
-
- 3-ISOBUTYL-1-METHYLXANTHINE
28822-58-4
- $8.00
- 99%
- Career Henan Chemical Co
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