ChemicalBook >> CAS DataBase List >>AI-10-49
AI-10-49
- CAS No.
- 1256094-72-0
- Chemical Name:
- AI-10-49
- Synonyms
- CS-2138;AI-10-49;AI 1049;AI1049;AI-10-49, 10 mM in DMSO;inhibit,AI 10 49,AI1049,Inhibitor;2,2'-[Oxybis(2,1-ethanediyloxy-5,2-pyridinediyl)]bis[6-(trifluoromethoxy)-1H-benzimidazole];1H-Benzimidazole,2,2'-[oxybis(2,1-ethanediyloxy-5,2-pyridinediyl)]bis[5-(trifluoromethoxy)-;1H-Benzimidazole, 2,2'-[oxybis(2,1-ethanediyloxy-5,2-pyridinediyl)]bis[6-(trifluoromethoxy)-;2,2'-(((Oxybis(ethane-2,1-diyl))bis(oxy))bis(pyridine-5,2-diyl))bis(6-(trifluoromethoxy)-1H-benzo[d]imidazole);2,2'-(5,5'-((oxybis(ethane-2,1-diyl))bis(oxy))bis(pyridine-5,2-diyl))bis(6-(trifluoromethoxy)-1H-benzo[d]imidazole)
- CBNumber:
- CB62737629
- Molecular Formula:
- C30H22F6N6O5
- Molecular Weight:
- 660.52
- MDL Number:
- MFCD28900686
- MOL File:
- 1256094-72-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
Last updated:2026-05-28 05:49:58
| Product description | Number | Pack Size | Price |
| AI-10-49 | A8694 | 5mg | $50 |
| AI-10-49 | A8694 | 10mg | $72 |
| AI-10-49 | A8694 | 25mg | $144 |
| AI-10-49 | AA009CDW | 2mg | $48 |
| AI-10-49 | AA009CDW | 5mg | $64 |
| Boiling point | 790.3±70.0 °C(Predicted) |
|---|---|
| Density | 1.478±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | ≥ 16.53mg/mL in DMSO |
| pka | 8.33±0.10(Predicted) |
| form | Powder |
| color | Off-white to yellow |
| FDA UNII | UBW5XL5U9W |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
AI-10-49 price More Price(33)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ApexBio Technology | A8694 | AI-10-49 | 1256094-72-0 | 5mg | $50 | 2026-05-06 | Buy |
| ApexBio Technology | A8694 | AI-10-49 | 1256094-72-0 | 10mg | $72 | 2026-05-06 | Buy |
| ApexBio Technology | A8694 | AI-10-49 | 1256094-72-0 | 25mg | $144 | 2026-05-06 | Buy |
| aablocks | AA009CDW | AI-10-49 | 1256094-72-0 | 2mg | $48 | 2026-05-28 | Buy |
| aablocks | AA009CDW | AI-10-49 | 1256094-72-0 | 5mg | $64 | 2026-05-28 | Buy |
AI-10-49 Chemical Properties,Uses,Production
Uses
AI-10-49 is an inhibitor of leukemic oncoprotein CBFβ-SMHHC. AI-10-49 inhibits the binding of CBFβ-SMMHCto the RUNX1 Runt domain with IC50 value of 0.26 μM. AI-10-49 can be used for the research of leukemia[1].
in vivo
AI-10-49 (200 mg/kg; per day) delays leukemia progression in mice[1].
| Animal Model: | Mice (Cbfb+/MYH11:Ras+/G12D leukemic cells)[1] |
| Dosage: | 200 mg/kg |
| Administration: | per day |
| Result: | Reduced leukemia expansion in vivo and survived significantly long. |
References
[1] Anuradha Illendula, et al. Chemical biology. A small-molecule inhibitor of the aberrant transcription factor CBFβ-SMMHC delays leukemia in mice. Science. 2015 Feb 13;347(6223):779-84. DOI:10.1126/science.aaa0314
AI-10-49 Preparation Products And Raw materials
Raw materials
Preparation Products
AI-10-49 Suppliers
Global( 73)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32467 | 58 |
| BOC Sciences | 16314854226; +16314854226 | inquiry@bocsci.com | United States | 19853 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471; | sales@sarms4muscle.com | China | 10473 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| Coresyn Pharmatech Co., Ltd. | +86-571-86626709 +86-18157142896 | cbc@coresyn.com | China | 9984 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3135 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39040 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11680 | 58 |
| Aceschem Inc. | +1-817863-6948 +1-（817）863-6948 | sales@aceschem.com | United States | 19632 | 58 |
AI-10-49
2,2'-[Oxybis(2,1-ethanediyloxy-5,2-pyridinediyl)]bis[6-(trifluoromethoxy)-1H-benzimidazole]
CS-2138
AI 1049;AI1049
1H-Benzimidazole, 2,2'-[oxybis(2,1-ethanediyloxy-5,2-pyridinediyl)]bis[6-(trifluoromethoxy)-
1H-Benzimidazole,2,2'-[oxybis(2,1-ethanediyloxy-5,2-pyridinediyl)]bis[5-(trifluoromethoxy)-
2,2'-(5,5'-((oxybis(ethane-2,1-diyl))bis(oxy))bis(pyridine-5,2-diyl))bis(6-(trifluoromethoxy)-1H-benzo[d]imidazole)
inhibit,AI 10 49,AI1049,Inhibitor
2,2'-(((Oxybis(ethane-2,1-diyl))bis(oxy))bis(pyridine-5,2-diyl))bis(6-(trifluoromethoxy)-1H-benzo[d]imidazole)
AI-10-49, 10 mM in DMSO
1256094-72-0
C30H22F6N6O5
