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2,2-DIMETHYL-1,3-DIOXAN-5-ONE

2,2-DIMETHYL-1,3-DIOXAN-5-ONE structure

CAS No.: 74181-34-3

Chemical Name:: 2,2-DIMETHYL-1,3-DIOXAN-5-ONE

Synonyms: 2,2-DIMETHYL-1,3-DIOXANE-5-ONE;AKOS 33;2,2-DIMETHYL-1,3-DIOXAN-5-ONE;2,2-dimethyl-1,3-dialkane-5-one;1,3-Dioxan-5-one, 2,2-dimethyl-;2,2-Dimethyl-1,3-dioxan-5-one>2,2-Dimethyl-1,3-dioxan-5-one,97%;2,2-Dimethyl-1,3-dioxan-5-one,99%;2,2-Dimethyl-1,3-dioxan-5-one, tech. 90%;2,2-Dimethyl-1,3-dioxan-5-one, technical, 90%

CBNumber:: CB6348744

Molecular Formula:: C6H10O3

Molecular Weight:: 130.14

MDL Number:: MFCD00671514

MOL File:: 74181-34-3.mol

MSDS File:: SDS

Last updated:2026-05-28 06:09:06

Product description	Number	Pack Size	Price
2,2-Dimethyl-1,3-dioxan-5-one >97.0%(GC)	D2397	1g	$85
2,2-Dimethyl-1,3-dioxan-5-one >97.0%(GC)	D2397	5g	$285
2,2-Dimethyl-1,3-dioxan-5-one	TRC-D472840-5G	5g	$581
2,2-Dimethyl-1,3-dioxan-5-one	TRC-D472840-1G	1g	$179
2,2-Dimethyl-1,3-dioxan-5-one	TRC-D472840-10G	10g	$1046
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2,2-DIMETHYL-1,3-DIOXAN-5-ONE Properties

Boiling point	40-46°C/14mm
Density	1,09 g/cm³
refractive index	1.4315
Flash point	>110°C
storage temp.	Inert atmosphere,Store in freezer, under -20°C
solubility	Chloroform (Sparingly), Ethyl Acetate (Slightly)
form	clear liquid
color	Colorless to Light yellow to Light orange
Water Solubility	Miscible with water and most organic solvents.
Sensitive	Air & Moisture Sensitive
BRN	3061933
InChI	InChI=1S/C6H10O3/c1-6(2)8-3-5(7)4-9-6/h3-4H2,1-2H3
InChIKey	ASFQDNDZFGFMMP-UHFFFAOYSA-N
SMILES	O1CC(=O)COC1(C)C
CAS DataBase Reference	74181-34-3(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS02

Signal word

Warning

Hazard statements

H226

Precautionary statements

P210-P233-P240-P241+P242+P243-P280-P303+P361+P353-P370+P378-P403+P235-P501

Hazard Codes

Risk Statements

36/37/38-41-37/38

Safety Statements

26-37/39-39-24/25

RIDADR

1993

HazardClass

PackingGroup

III

HS Code

29141900

Limited Quantities

5.0 L (1.3 gallons) (liquid)

Excepted Quantities

Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L)

NFPA 704

	1
0		0

2,2-DIMETHYL-1,3-DIOXAN-5-ONE price More Price(59)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	D2397	2,2-Dimethyl-1,3-dioxan-5-one >97.0%(GC)	74181-34-3	1g	$85	2026-04-30	Buy
TCI Chemical	D2397	2,2-Dimethyl-1,3-dioxan-5-one >97.0%(GC)	74181-34-3	5g	$285	2026-04-30	Buy
TRC	TRC-D472840-5G	2,2-Dimethyl-1,3-dioxan-5-one	74181-34-3	5g	$581	2026-06-03	Buy
TRC	TRC-D472840-1G	2,2-Dimethyl-1,3-dioxan-5-one	74181-34-3	1g	$179	2026-06-03	Buy
TRC	TRC-D472840-10G	2,2-Dimethyl-1,3-dioxan-5-one	74181-34-3	10g	$1046	2026-06-03	Buy

Product number	Packaging	Price	Buy
D2397	1g	$85	Buy
D2397	5g	$285	Buy
TRC-D472840-5G	5g	$581	Buy
TRC-D472840-1G	1g	$179	Buy
TRC-D472840-10G	10g	$1046	Buy

2,2-DIMETHYL-1,3-DIOXAN-5-ONE Chemical Properties,Uses,Production

Chemical Properties

clear yellow liquid

Uses

2,2-Dimethyl-1,3-dioxan-5-one is used in the preparation of 2,2-dimethyl-[1,3]dioxan-5-ol by reducing with lithium aluminum hydride. It is also used in the annulation of bete-(hetero)aryl-alfa-nitro-alfa,beta-enals.

Synthesis

(5-AMINO-2,2-DIMETHYL-[1,3]DIOXAN-5-YL)-METHANOL

53104-32-8

74181-34-3

The general procedure for the synthesis of 2,2-dimethyl-1,3-dioxan-5-one from 5-amino-2,2-dimethyl-1,3-dioxan-5-methanol was as follows: first, 2,2-dimethoxypropane (21.5 mL, 175 mmol) and p-toluenesulfonic acid monohydrate (1.58 g, 7.93 mmol) were added to a solution of tris(hydroxymethyl)aminomethane ( 25.2 g, 159 mmol) in a solution of N,N-dimethylformamide (DMF, 180 mL). The reaction mixture was stirred at room temperature for 22 hours. After completion of the reaction, the mixture was diluted with ethyl acetate and neutralized with the addition of triethylamine. Subsequently, the solvent was concentrated under reduced pressure to remove the solvent and the crude product obtained was purified by silica gel column chromatography (eluent: n-hexane/ethyl acetate, 5:1) to afford 2,2-dimethyl-5-amino-5-hydroxymethyl-1,3-dioxane (20.9 g, 78% yield) as a colorless solid. The structure of this intermediate was confirmed by 1H NMR (400 MHz, CDCl3): δ 3.80 (d, J = 12.0 Hz, 2H), 3.60 (d, J = 12.0 Hz, 2H), 3.53 (s, 2H), 2.61 (s, 2H), 1.45 (s, 3H), 1.41 (s, 3H). Next, the above intermediate (10.2 g, 62.1 mmol) was dissolved in water (60 mL) and potassium dihydrogen phosphate (KH2PO4, 8.51 g, 621 mmol) was added. An aqueous solution of sodium periodate (NaIO4) (0.5 M, 125 mL, 63 mmol) was slowly added dropwise at 0 °C. After completion of the dropwise addition, the reaction mixture was stirred for 1 h at room temperature. After completion of the reaction, the product was extracted with dichloromethane and the organic layer was washed sequentially with 5% aqueous sodium thiosulfate and saturated saline and dried over anhydrous sodium sulfate. Finally, the solvent was removed by concentration under reduced pressure to afford the target compound 2,2-dimethyl-1,3-dioxan-5-one (7.35 g, 91% yield) as a colorless oil. Its structure was confirmed by 1H NMR (400 MHz, CDCl3): δ 4.15 (s, 4H), 1.45 (s, 6H).

References

[1] Australian Journal of Chemistry, 2001, vol. 54, # 12, p. 769 - 776
[2] Bioorganic and Medicinal Chemistry, 2014, vol. 22, # 21, p. 5891 - 5901
[3] Helvetica Chimica Acta, 2003, vol. 86, # 7, p. 2458 - 2470
[4] Synthesis, 1998, # 6, p. 879 - 882
[5] Canadian Journal of Chemistry, 1995, vol. 73, # 10, p. 1616 - 1626

2,2-DIMETHYL-1,3-DIOXAN-5-ONE synthesis

Synthesis of 2,2-DIMETHYL-1,3-DIOXAN-5-ONE from (5-AMINO-2,2-DIMETHYL-[1,3]DIOXAN-5-YL)-METHANOL

2,2-DIMETHYL-1,3-DIOXAN-5-ONE Preparation Products And Raw materials

Raw materials

(2,2-dimethyl-5-nitro-1,3-dioxan-5-yl)methanol 1H,3H-Pyrrolo[1,2-c]oxazol-1-one, 3-(1,1-diMethylethyl)tetrahydro-, (3R,7aS)- (5-AMINO-2,2-DIMETHYL-[1,3]DIOXAN-5-YL)-METHANOL Sodium periodate Pyrrolidine, 2-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]methyl]-, (2S)-

Potassium Phosphate Monobasic TRIS hydrochloride Pivaldehyde 2,2-Dimethoxypropane

1of2

Preparation Products

1,3-Dioxan-5-ol, 2,2-dimethyl- 1-Pyrrolidino-1-cyclohexene 2,2-Dimethyl-5-vinyl-1,3-dioxan-5-ol

2,2-DIMETHYL-1,3-DIOXAN-5-ONE Suppliers

Global( 142)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Speranza Chemical Co., Ltd.	+86-86-075521030354 +8618688942810	sophieliu@speranzachem.com	China	923	55
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29815	58
Accela ChemBio Inc.	+1-858-6993322	info@accelachem.com	United States	21193	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49979	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	+8613580539051	joe@yuhengpharm.com	CHINA	21142	58
Finetech Industry Limited	+86-27-8746-5837 +8619945049750	info@finetechnology-ind.com	China	9539	58
Dayang Chem (Hangzhou) Co.,Ltd.	+86-0571-88938639 +8617705817739	info@dycnchem.com	China	52705	58
CD Chemical Group Limited	+8615986615575	info@codchem.com	China	17259	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418684 +8618949823763	sales@tnjchem.com	China	25356	58

Supplier	Advantage
Speranza Chemical Co., Ltd.	55
career henan chemical co	58
Accela ChemBio Inc.	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	58
Finetech Industry Limited	58
Dayang Chem (Hangzhou) Co.,Ltd.	58
CD Chemical Group Limited	58
Hefei TNJ Chemical Industry Co.,Ltd.	58

View Lastest Price from 2,2-DIMETHYL-1,3-DIOXAN-5-ONE manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2019-07-06	2,2-DIMETHYL-1,3-DIOXAN-5-ONE 74181-34-3	$1.00	1KG	99%		Career Henan Chemical Co

2,2-DIMETHYL-1,3-DIOXAN-5-ONE
74181-34-3
$1.00
99%
Career Henan Chemical Co

2,2-DIMETHYL-1,3-DIOXAN-5-ONE Spectrum

2,2-DIMETHYL-1,3-DIOXAN-5-ONE(74181-34-3)¹HNMR

74181-34-3(2,2-DIMETHYL-1,3-DIOXAN-5-ONE)Related Search:

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