8-HYDROXY-7-(6-SULFO-2-NAPHTHYLAZO)-5-QUINOLINESULFONIC ACID DISODIUM SALT
- CAS No.
- 56932-43-5
- Chemical Name:
- 8-HYDROXY-7-(6-SULFO-2-NAPHTHYLAZO)-5-QUINOLINESULFONIC ACID DISODIUM SALT
- Synonyms
- NSC 87877 sodium;NAPHTHYLAZOXINE S;NAPHTHYLAZOXINE 6S;NSC-87877 disodium;NSC-87877(sodium salt);nsc-87877 disodium salt;NSC87877/Naphthylazoxine6S;NAPHTHYLAZOXINE S DISODIUM SALT;NSC-87877 disodium, 10 mM in DMSO;SHP1/2 PTPase Inhibitor, NSC-87877
- CBNumber:
- CB6408024
- Molecular Formula:
- C19H11N3Na2O7S2
- Molecular Weight:
- 503.42
- MDL Number:
- MFCD00041863
- MOL File:
- 56932-43-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| SHP1/2 PTPase Inhibitor, NSC-87877 - CAS 56932-43-5 - Calbiochem | 565851 | 50MG | $175 |
| NSC-87877 disodium 98.0% | CS-0045315 | 5mg | $65 |
| NSC-87877 disodium 98.0% | CS-0045315 | 10mg | $108 |
| NSC-87877 disodium 98.0% | CS-0045315 | 25mg | $217 |
| NSC-87877 disodium 98.0% | CS-0045315 | 50mg | $379 |
| storage temp. | Inert atmosphere,Room Temperature |
|---|---|
| solubility | water: 10 mg/mL |
| form | Solid |
| color | Brown to black |
| Water Solubility | water: 10mg/mL |
| InChIKey | YOGRUDWAJPVHEL-LLDDCTHSSA-L |
| SMILES | [Na+].[Na+].[S](=O)(=O)([O-])c1cc2c(cc(cc2)N\N=C3/C=C(c4c(nccc4)C/3=O)[S](=O)(=O)[O-])cc1 |
| EPA Substance Registry System | 5-Quinolinesulfonic acid, 8-hydroxy-7-[(6-sulfo-2-naphthalenyl)azo]-, disodium salt (56932-43-5) |
| UNSPSC Code | 12352200 |
| NACRES | NA.54 |
SAFETY
Risk and Safety Statements
| Safety Statements | 24/25 |
|---|---|
| WGK Germany | WGK 2 |
| TSCA | TSCA listed |
| Storage Class | 11 - Combustible Solids |
8-HYDROXY-7-(6-SULFO-2-NAPHTHYLAZO)-5-QUINOLINESULFONIC ACID DISODIUM SALT price More Price(43)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 565851 | SHP1/2 PTPase Inhibitor, NSC-87877 - CAS 56932-43-5 - Calbiochem | 56932-43-5 | 50MG | $175 | 2026-04-30 | Buy |
| ChemScene | CS-0045315 | NSC-87877 disodium 98.0% | 56932-43-5 | 5mg | $65 | 2026-06-04 | Buy |
| ChemScene | CS-0045315 | NSC-87877 disodium 98.0% | 56932-43-5 | 10mg | $108 | 2026-06-04 | Buy |
| ChemScene | CS-0045315 | NSC-87877 disodium 98.0% | 56932-43-5 | 25mg | $217 | 2026-06-04 | Buy |
| ChemScene | CS-0045315 | NSC-87877 disodium 98.0% | 56932-43-5 | 50mg | $379 | 2026-06-04 | Buy |
8-HYDROXY-7-(6-SULFO-2-NAPHTHYLAZO)-5-QUINOLINESULFONIC ACID DISODIUM SALT Chemical Properties,Uses,Production
Chemical Properties
dark red to red-brown powder
Uses
NSC-87877 disodium is a potent inhibitor of Shp2 and Shp1 protein tyrosine phosphatases (SH-PTP2 and SH-PTP1), with IC50 values of 0.318 μM, 0.355 μM shp2 and shp1, respectively[1]. NSC-87877 also inhibits dual-specificity phosphatase 26 (DUSP26)[2].
Biological Activity
Cell permeable: yes', 'Primary Target
SHP1/2 PTPase', 'Product does not compete with ATP.', 'Reversible: no', 'Target IC50: 355 nM and 318 nM against SHP-1 and SHP-2 protein tyrosine phosphatases, respectively
in vivo
NSC-87877 (30mg/kg, IP once daily for 15 days) possesses excellent anti- neuroblastoma activity[3].
| Animal Model: | Intrarenal neuroblastoma (NB) tumor mouse model in female nude mice[3]. |
| Dosage: | 30mg/kg. |
| Administration: | IP once daily for 15 days. |
| Result: | Significantly inhibited NB tumor growth. |
References
[1] Chen L, et al. Discovery of a novel shp2 protein tyrosine phosphatase inhibitor. Mol Pharmacol. 2006 Aug;70(2):562-70. DOI:10.1124/mol.106.025536
[2] Song M, et al. NSC-87877, inhibitor of SHP-1/2 PTPs, inhibits dual-specificity phosphatase 26 (DUSP26). Biochem Biophys Res Commun. 2009 Apr 17;381(4):491-5. DOI:10.1016/j.bbrc.2009.02.069
[3] Y Shi, et al. NSC-87877 inhibits DUSP26 function in neuroblastoma resulting in p53-mediated apoptosis. Cell Death Dis. 2015 Aug 6;6(8):e1841. DOI:10.1038/cddis.2015.207
8-HYDROXY-7-(6-SULFO-2-NAPHTHYLAZO)-5-QUINOLINESULFONIC ACID DISODIUM SALT Preparation Products And Raw materials
Raw materials
Preparation Products
8-HYDROXY-7-(6-SULFO-2-NAPHTHYLAZO)-5-QUINOLINESULFONIC ACID DISODIUM SALT Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32466 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3135 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39037 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +86-18621343501; +undefined18621343501 | product@acmec-e.com | China | 33324 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| SHANGHAI KEAN TECHNOLOGY CO., LTD. | +8613817748580 | cooperation@kean-chem.com | China | 40066 | 58 |
| DAYANG CHEM (HANGZHOU) CO.,LTD | +86-88938639 +86-17705817739 | info@dycnchem.com | China | 53803 | 58 |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 9920 | 65 |
| Guangzhou Isun Pharmaceutical Co., Ltd | 020-39119399 18927568969 | isunpharm@qq.com | China | 4784 | 55 |
| Bide Pharmatech Ltd. | 400-400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
View Lastest Price from 8-HYDROXY-7-(6-SULFO-2-NAPHTHYLAZO)-5-QUINOLINESULFONIC ACID DISODIUM SALT manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-15 | NSC-87877 disodium
56932-43-5
|
$39.00-117.00 | 98.00% | 10g | TargetMol Chemicals Inc. |
-
- NSC-87877 disodium
56932-43-5
- $39.00-117.00
- 98.00%
- TargetMol Chemicals Inc.
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