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ChemicalBook >> CAS DataBase List >>AC-DEVD-CHO

AC-DEVD-CHO

CAS No.
169332-60-9
Chemical Name:
AC-DEVD-CHO
Synonyms
CASPASE-3 INHIBITOR;MF 191;AC-DEVD-CHO;AC-DEVD-ALDEHYDE;AC-DEVD-CHO?, >98%;Ac-DEVD-CHO acetate;ACETYL-DEVD-ALDEHYDE;Ac-Asp-Glu-Val-Asp-H;CASPASE-3 INHIBITOR I;AC-DEVD-CHO USP/EP/BP
CBNumber:
CB6488321
Molecular Formula:
C20H30N4O11
Molecular Weight:
502.47
MDL Number:
MFCD00671412
MOL File:
169332-60-9.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-27 17:00:41
Product description Number Pack Size Price
Caspase-3 Inhibitor I 235420 1mg $130
Caspase-3 Inhibitor I 235420 5mg $523
Ac-DEVD-CHO 99.76% CS-7676 1mg $76
Ac-DEVD-CHO 99.76% CS-7676 5mg $260
Ac-DEVD-CHO 99.76% CS-7676 10mg $379
More product size

AC-DEVD-CHO Properties

Boiling point 1021.1±65.0 °C(Predicted)
Density 1.374±0.06 g/cm3(Predicted)
RTECS EK7643000
storage temp. -20°C
solubility H2O: 1 mg/mL
form powder
pka 4.19±0.10(Predicted)
color white
biological source synthetic
Water Solubility H2O: 1mg/mL
Sensitive Moisture Sensitive
Sequence N-Acetyl-Asp-Glu-Val-Asp-al
InChIKey UMBVAPCONCILTL-UHFFFAOYSA-N
SMILES [H]C(=O)C(CC(O)=O)NC(=O)C(NC(=O)C(CCC(O)=O)NC(=O)C(CC(O)=O)NC(C)=O)C(C)C
UNSPSC Code 12352209
NACRES NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
PPE Eyeshields, Gloves, type N95 (US)
WGK Germany  3
Storage Class 11 - Combustible Solids

AC-DEVD-CHO price More Price(41)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 235420 Caspase-3 Inhibitor I 169332-60-9 1mg $130 2026-04-30 Buy
Sigma-Aldrich 235420 Caspase-3 Inhibitor I 169332-60-9 5mg $523 2026-04-30 Buy
ChemScene CS-7676 Ac-DEVD-CHO 99.76% 169332-60-9 1mg $76 2026-06-04 Buy
ChemScene CS-7676 Ac-DEVD-CHO 99.76% 169332-60-9 5mg $260 2026-06-04 Buy
ChemScene CS-7676 Ac-DEVD-CHO 99.76% 169332-60-9 10mg $379 2026-06-04 Buy
Product number Packaging Price Buy
235420 1mg $130 Buy
235420 5mg $523 Buy
CS-7676 1mg $76 Buy
CS-7676 5mg $260 Buy
CS-7676 10mg $379 Buy

AC-DEVD-CHO Chemical Properties,Uses,Production

Uses

Reversible inhibitor of interleukin-1beta converting enzyme (ICE); also inhibits caspase-3 cleavage of poly(ADP-ribose) polymerase

Uses

N-Acetyl-Asp-Glu-Val-Asp-al has been used as a caspase inhibitor in muscle samples, smooth muscle cells and Jurkat T-cells.

Definition

ChEBI: A tetrapeptide consisting of two L-aspartic acid residues, an L-glutamyl residue and an L-valine residue with an acetyl group at the N-terminal and with the C-terminal carboxy group reduced to an aldehyde. It is an inhibitor of caspase-3/7.

General Description

N-Acetyl-Asp-Glu-Val-Asp-al (Ac-DEVD-CHO) is a tetrapeptide with N-terminal acetylation and C-terminal aldehyde conjugation.

Biochem/physiol Actions

N-Acetyl-Asp-Glu-Val-Asp-al (Ac-DEVD-CHO) aids in the recovery of stunned myocardium by its caspase inhibition functionality.

in vivo

Compare with model group, in CI group, the concentrations of serum BUN are decreased significantly at all time points after operation and those of Cr are decreased significantly at 6 hours, then restored to those of the sham group at 12 hours and 24 hours; the concentrations of serum TNF-α, IL-6 are decreased and those of IL-10 are elevated significantly at all time points. [TNF-α (μg/L) 6 hours: 436.2±64.2 vs. 653.6±8.9, 12 hours: 233.4±85.4 vs. 579.7±137.1, 24 hours: 151.0±90.3 vs. 551.0±119.8, IL-6 (μg/L) 6 hours: 1033.2±345.8 vs. 1 595.3±159.4, 12 hours: 366.3±68.3 vs. 1 330.7±249.8, 24 hours: 241.2±208.4 vs. 815.3±572.7, IL-10 (μg/L) 6 hours: 33.6±10.4 vs. 26.6±4.5, 12 hours: 37.2±5.0 vs. 24.5±4.3, 24 hours: 38.3±5.5 vs. 18.2±1.6, all P<0.05]; the renal cell apoptosis rates are decreased significantly at all time points: apoptosis rates 6 hours: (13.9±3.2)% vs. (18.3±1.4)%, 12 hours: (10.5±3.6)% vs. (15.9±3.5)%, 24 hours: (8.4±1.8)% vs.(12.5±2.1)%[5].

IC 50

Caspase 3: 0.23 nM (Ki); Caspase-8: 0.92 nM (Ki); Caspase-7: 1.6 nM (Ki); Caspase-10: 12 nM (Ki); Caspase-1: 18 nM (Ki); Caspase-6: 31 nM (Ki); Caspase-9: 60 nM (Ki); Caspase-4: 132 nM (Ki); Caspase-5: 205 nM (Ki); Caspase-2: 1710 nM (Ki)

AC-DEVD-CHO Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 118)Suppliers
Supplier Tel Email Country ProdList Advantage
Shenzhen Nexconn Pharmatechs Ltd 		+86-755-89396905 +86-15013857715 admin@nexconn.com China 10403 58
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19936 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250 1059@dideu.com China 29093 58
BOC Sciences 		16314854226; +16314854226 inquiry@bocsci.com United States 19853 58
Nextpeptide Inc 		+86-0571-81612335 +8613336028439 sales@nextpeptide.com China 19908 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
Hangzhou MolCore BioPharmatech Co.,Ltd. 		+86-057181025280; +8617767106207 sales@molcore.com China 49734 58
TargetMol Chemicals Inc. 		+1-781-999-5354; support@targetmol.com United States 39037 58
Aladdin Scientific 		tp@aladdinsci.com United States 57505 58
Changsha MOL Changes Biotechnology Co., Ltd. 		+8619375158599 info@molchanges.com China 5218 58

View Lastest Price from AC-DEVD-CHO manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Ac-DEVD-CHO acetate pictures 2026-07-27 Ac-DEVD-CHO acetate
$70.00-336.00 98.54% 10g TargetMol Chemicals Inc.
N-ACETYL-L-ALPHA-ASPARTYL-L-ALPHA-GLUTAMYL-N-(2-CARBOXY-1-FORMYLETHYL)-L VALINAMIDE N-AC-ASP-GLU-VAL-ASP-CHO N-ACETYL-ASP-GLU-VAL-ASP-AL N-ACETYL-ASP-GLU-VAL-ASP-CHO (ALDEHYDE) CPP32/APOPAIN INHIBITOR CASPASE-3 INHIBITOR I CASPASE-3 INHIBITOR (ALDEHYDE) ACETYL-DEVD-ALDEHYDE ACETYL-L-ASPARTYL-L-GLUTAMYL-L-VALYL-L-ASPART-1-AL ACETYL-ASP-GLU-VAL-ASP-ALDEHYDE AC-DEVD-CHO AC-DEVD-ALDEHYDE AC-ASP-GLU-VAL-ASP-ALDEHYDE AC-ASP-GLU-VAL-ASP-ALDEHYDE (PSEUDO ACID) AC-ASP-GLU-VAL-ASP-H (ALDEHYDE) AC-ASP-GLU-VAL-ASP-CHO Acetyl-aspartyl-glutamyl-valyl-aspartal CASPASE 3 (APOPAIN) INHIBITOR 1 MF 191 N-acetyl-Asp-Glu-Val-Asp-Ala (4S,7S,10S,13S)-7-(2-carboxyethyl)-4-(carboxyMethyl)-13-forMyl-10-isopropyl-2,5,8,11-tetraoxo-3,6,9,12-tetraazapentadecan-15-oic acid Ac-Asp-Glu-Val-Asp-H Ac-DEVD-CHO,N-Acetyl-Asp-Glu-Val-Asp-al, >98% AC-DEVD-CHO?, >98% Caspase-3 Inhibitor I - CAS 169332-60-9 - Calbiochem CASPASE-3 INHIBITOR I;N-AC-ASP-GLU-VAL-ASP-CHO;ACETYL-ASPARTYL-GLUTAMYL-VALYL-ASPARTAL L-Valinamide, N-acetyl-L-α-aspartyl-L-α-glutamyl-N-[(1S)-2-carboxy-1-formylethyl]- N-Acetyl-Asp-Glu-Val-Asp-al >=95%, powder AC-DEVD-CHO USP/EP/BP Ac-DEVD-CHO，N-Acetyl-Asp-Glu-Val-Asp-al Caspase 3 Inhibitor I,Caspase3 Inhibitor I AcDEVDCHO,Ac DEVD CHO Ac-DEVD-CHO acetate CASPASE-3 INHIBITOR 169332-60-9 Caspase 10 Caspases Cell Biology Cell Signaling and Neuroscience Apoptosis and Cell Cycle BioChemical Inhibitors peptides Caspase 10 Caspase 3 Caspase 7 Caspase 8 Caspase Inhibitors Caspase Inhibitors and Substrates Peptides and Proteins Peptides for Cell Biology Protease Inhibitor Specificity Index Protease Inhibitors A to C A-AM Aldehydes and Substrates Apoptosis and Cell Cycle
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