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Integrin α2b (D8V7H) Rabbit mAb

CAS No.
Chemical Name:
Integrin α2b (D8V7H) Rabbit mAb
Synonyms
Integrin α2b (D8V7H) Rabbit mAb
CBNumber:
CB66259194
Molecular Formula:
Molecular Weight:
0
MDL Number:
MOL File:
Mol file

Integrin α2b (D8V7H) Rabbit mAb Chemical Properties,Uses,Production

Source

Rabbit

Reactivity

Human

Background

Integrins are α/β heterodimeric cell surface receptors that play a pivotal role in cell adhesion and migration, as well as in growth and survival. The integrin family contains at least 18 α and 8 β subunits that form 24 known integrins with distinct tissue distribution and overlapping ligand specificities. Integrins not only transmit signals to cells in response to the extracellular environment, but also sense intracellular cues to alter their interaction with the extracellular environment.Integrin α2b is a cell-surface adhesion molecule that undergoes proteolytic cleavage to yield disulfide-linked heavy and light chains, which together with glycoprotein IIIb, forms a major fibrinogen receptor in activated platelets. Mutations in the corresponding ITGA2B gene can result in Glanzmann thrombasthenia, a bleeding disorder characterized by lack of platelet aggregation.

References

[1] Hood, J.D. and Cheresh, D.A. (2002) Nat Rev Cancer 2, 91-100.
[2] Liu, S. et al. (2000) J Cell Sci 113 ( Pt 20), 3563-71.
[3] Calvete, J.J. et al. (1990) FEBS Lett 272, 37-40.
[4] Vannier, C. et al. (2010) Klin Padiatr 222, 150-3.
[5] Nurden, A.T. et al. (2011) Blood 118, 5996-6005.

Integrin α2b (D8V7H) Rabbit mAb Preparation Products And Raw materials

Raw materials

Preparation Products

Integrin α2b (D8V7H) Rabbit mAb Suppliers

Global( 3)Suppliers
Supplier Tel Email Country ProdList Advantage
Beijing Zhongbei Linge Technology Development Co., Ltd. -- bjzblg@126.com CHINA 2631 58
Hangzhou Kaitai Biotechnology Co., Ltd. -- bio168@yahoo.cn CHINA 4401 58
Shanghai Gaochuang Chemical Technology Co., Ltd. -- gaochem@163.com CHINA 6995 58
Integrin α2b (D8V7H) Rabbit mAb
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