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Mono-Methyl Arginine (R*GG) (D5A12) Rabbit mAb

CAS No.
Chemical Name:
Mono-Methyl Arginine (R*GG) (D5A12) Rabbit mAb
Synonyms
Mono-Methyl Arginine (R*GG) (D5A12) Rabbit mAb
CBNumber:
CB66261212
Molecular Formula:
Molecular Weight:
0
MDL Number:
MOL File:
Mol file

Mono-Methyl Arginine (R*GG) (D5A12) Rabbit mAb Chemical Properties,Uses,Production

Source

Rabbit

Reactivity

All

Background

Arginine methylation is a prevalent PTM found on both nuclear and cytoplasmic proteins. Arginine methylated proteins are involved in many different cellular processes, including transcriptional regulation, signal transduction, RNA metabolism, and DNA damage repair. Arginine methylation is carried out by the arginine N-methyltransferase family of enzymes that catalyze the transfer of a methyl group from S-adenosylmethionine to a guanidine nitrogen of arginine. There are three different types of arginine methylation: asymmetric dimethylarginine, where two methyl groups are placed on one of the terminal nitrogen atoms of the guanidine group of arginine; symmetric dimethylarginine, where one methyl group is placed on each of the two terminal guanidine nitrogens of arginine; and monomethylarginine, where a single methyl group is placed on one of the terminal nitrogen atoms of arginine. Each of these modifications has potentially different functional consequences. Though all PRMT proteins catalyze the formation of MMA, Type I PRMTs add an additional methyl group to produce aDMA, while Type II PRMTs produce sDMA. Methylated arginine residues often reside in glycine-arginine rich protein domains, such as RGG, RG, and RXR repeats. However, PRMT4/CARM1 and PRMT5 methylate arginine residues within proline-glycine-methionine rich motifs.

References

[1] t Bedford, M.T. and Richard, S. (2005) Mol Cell 18, 263-72.
[2] Pahlich, S. et al. (2006) Biochim Biophys Acta 1764, 1890-903.
[3] Bedford, M.T. and Clarke, S.G. (2009) Mol Cell 33, 1-13.
[4] McBride, A.E. and Silver, P.A. (2001) Cell 106, 5-8.
[5] Gary, J.D. and Clarke, S. (1998) Prog Nucleic Acid Res Mol Biol 61, 65-131.
[6] Cheng, D. et al. (2007) Mol Cell 25, 71-83.
[7] Dhar, S. et al. (2013) Sci Rep 3, 1311.

Mono-Methyl Arginine (R*GG) (D5A12) Rabbit mAb Preparation Products And Raw materials

Raw materials

Preparation Products

Mono-Methyl Arginine (R*GG) (D5A12) Rabbit mAb Suppliers

Global( 10)Suppliers
Supplier Tel Email Country ProdList Advantage
Shanghai Universal Biotech Co.,Ltd 15921930842 15921930842 yh-wang@univ-bio.com China 25021 58
Cell Signaling Technology Inc 21-80243558 86218024 info@cellsignal.cn China 6427 58
Beijing Dongling Technology Co., Ltd. 13051591126 CHINA 6726 58
Beijing Boning Biotechnology Co., Ltd. 010-67500625 18210120938 384669408@qq.com China 6395 58
Guangzhou Keda Heng New Technology Co., Ltd. 17328662120 CHINA 6139 58
Guangzhou Bingheng Biotechnology Co., Ltd. 13631342304 CHINA 6888 58
Mono-Methyl Arginine (R*GG) (D5A12) Rabbit mAb
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