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9-Fluor-11β,17,21-trihydroxy-16β-methylpregna-1,4-dien-3,20-dion-17-valerat

Betamethasone 17-valerate Struktur
2152-44-5
CAS-Nr.
2152-44-5
Bezeichnung:
9-Fluor-11β,17,21-trihydroxy-16β-methylpregna-1,4-dien-3,20-dion-17-valerat
Englisch Name:
Betamethasone 17-valerate
Synonyma:
BETAMETHASONE VALERATE;VALISONE;Betaderm;BETNOVATE;BETHAMETASONE VALERATE;Luxiq;Betoid;Valison;9α-Fluo;Deviphos
CBNumber:
CB1317879
Summenformel:
C27H37FO6
Molgewicht:
476.58
MOL-Datei:
2152-44-5.mol

9-Fluor-11β,17,21-trihydroxy-16β-methylpregna-1,4-dien-3,20-dion-17-valerat Eigenschaften

Schmelzpunkt:
183-184°
alpha 
D +77° (dioxane)
Siedepunkt:
598.9±50.0 °C(Predicted)
Dichte
1.1174 (estimate)
storage temp. 
2-8°C
L?slichkeit
Practically insoluble in water, freely soluble in acetone and in methylene chloride, soluble in ethanol (96 per cent).
Aggregatzustand
Solid
pka
12.90±0.70(Predicted)
Farbe
White
Merck 
13,1183
BRN 
4240001
InChIKey
SNHRLVCMMWUAJD-SUYDQAKGSA-N
SMILES
[C@]12(C)C[C@@H]([C@]3(F)[C@@]4(C)C=CC(=O)C=C4CC[C@@]3([H])[C@]1([H])C[C@H](C)[C@@]2(C(=O)CO)OC(=O)CCCC)O |&1:0,3,4,6,16,18,21,23,r|
CAS Datenbank
2152-44-5(CAS DataBase Reference)
EPA chemische Informationen
.beta.-Methasone 17-valerate (2152-44-5)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher Xn
R-S?tze: 48
S-S?tze: 22-24/25
WGK Germany  WGK 2
RTECS-Nr. TU3835000
HS Code  2937229000
Speicherklasse 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects
Hazard Classifications Repr. 1B
STOT RE 2
Toxizit?t mouse,LD50,intraperitoneal,632mg/kg (632mg/kg),Shikoku Igaku Zasshi. Shikoku Medical Journal. Vol. 29, Pg. 153, 1973.
Bildanzeige (GHS) Health Hazard (GHS08)
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H373 Kann die Organe sch?digen bei l?ngerer oder wiederholter Exposition. Spezifische Zielorgan-Toxizit?t (wiederholte Exposition) Kategorie 2 Warnung P260, P314, P501
Sicherheit
P201 Vor Gebrauch besondere Anweisungen einholen.
P202 Vor Gebrauch alle Sicherheitshinweise lesen und verstehen.
P260 Dampf/Aerosol/Nebel nicht einatmen.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P308+P313 BEI Exposition oder falls betroffen: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen.
P405 Unter Verschluss aufbewahren.

9-Fluor-11β,17,21-trihydroxy-16β-methylpregna-1,4-dien-3,20-dion-17-valerat Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R48:Gefahr ernster Gesundheitssch?den bei l?ngerer Exposition.

S-S?tze Betriebsanweisung:

S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.

Chemische Eigenschaften

White Solid

Definition

ChEBI: Betamethasone valerate is a steroid ester that is betamethasone in which the hydroxy group at the 17alpha position has been converted to the corresponding pentanoate ester. It has a role as an anti-inflammatory drug. It is a steroid ester, a 20-oxo steroid, a 21-hydroxy steroid, an 11beta-hydroxy steroid, a fluorinated steroid, a 3-oxo-Delta(1),Delta(4)-steroid and a primary alpha-hydroxy ketone. It is functionally related to a betamethasone.

Indications

Betamethasone valerate (Psorion, Beta-Val, Luxiq) is a synthetic fluorinated corticosteroid.

Nebenwirkungen

Common side effects. These may affect up to 1 in 10 people: a. itchy skin. b. local skin burning or pain Very rare side effects.
These may affect up to 1 in 10,000 people. Use of Betnovate Scalp Application for a long period of time, or use under an airtight dressing, may cause the following symptoms: c. increased weight. d. moon face / rounding of theface. e. obesity. f. skin thinning, this may cause stretch marks. g. skin wrinkling. h. skin dryness. i. the appearance of blood vessels under the surface of your skin. j. changes to the colour of yourskin. k. increased body hair l. hair loss / lack of hair growth / damaged looking hair.
Other very rare skin reactions that may occur are: m. allergic reaction at the site ofapplication. n. worsening of condition. o. application site irritation. p. redness. q. rash or hives. r. If you have psoriasis you may get raised bumps with pus under the skin. This can happen very rarely during or after treatment and is known as pustular psoriasis. s. skin infection. In children also look out for the following symptoms: t. delayed weight gain u. slow growth.

9-Fluor-11β,17,21-trihydroxy-16β-methylpregna-1,4-dien-3,20-dion-17-valerat Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


9-Fluor-11β,17,21-trihydroxy-16β-methylpregna-1,4-dien-3,20-dion-17-valerat Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 550)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Nanjing Shizhou Biotechnology Co., Ltd
+86-15850508050
sean.lv@synzest.com China 323 58
Hebei Kangcang new material Technology Co., LTD
+8615713292910
Nancy@kangcang.com.cn China 341 58
Hebei Chuanghai Biotechnology Co., Ltd
+8615350571055
Sibel@chuanghaibio.com China 8738 58
Henan Fengda Chemical Co., Ltd
+86-371-86557731 +86-13613820652
info@fdachem.com China 20122 58
Shaanxi TNJONE Pharmaceutical Co., Ltd
+8618092446649
sarah@tnjone.com China 1143 58
Shaanxi Xianhe Biotech Co., Ltd
+86-17709210191; +8617709210191
Jerry@xhobio.com China 906 58
Wuhan JiyunZen Tech Co., Ltd.
+86-18062099985
Amyjiyunzen@yeah.net China 672 58
Frapp's ChemicalNFTZ Co., Ltd.
+86 (576) 8169-6106
sales@frappschem.com China 880 50
Beijing Cooperate Pharmaceutical Co.,Ltd
010-60279497
sales01@cooperate-pharm.com CHINA 1803 55
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21587 55

2152-44-5(9-Fluor-11β,17,21-trihydroxy-16β-methylpregna-1,4-dien-3,20-dion-17-valerat)Verwandte Suche:


  • pregna-1,4-diene-3,20-dione,9-fluoro-11,21-dihydroxy-16-methyl-17-((1-oxopenty
  • 9-fluoro-11beta,17,21-trihydroxy-16beta-methylpregna-1,4-diene-3,20-dione 17-valerate
  • 9ALPHA-FLUORO-16BETA-METHYLPREDNISOLONE 17-VALERATE
  • 9ALPHA-FLUORO-16BETA-METHYL-11BETA,17ALPHA,21-TRIHYDROXY-1,4-PREGNADIENE-3,20-DIONE 17-VALERATE
  • 1,4-PREGNADIENE-11BETA,17ALPHA,21-TRIOL-9ALPHA-FLUORO-16BETA-METHYL-3,20-DIONE 17-VALERATE
  • 1,4-pregnadiene-11b,17a,21-triol-9a-fluoro-16b-methyl-3,20-dione 17-valerate
  • 9α-Fluoro-16β-methylprednisolone 17-valerate, Betnovate, 9α-Fluoro-16β-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione 17-valerate, 1,4-Pregnadiene-11β,17α,21-triol-9α-fluoro-16β-methyl-3,20-dione 17-valerate
  • BetaMethasone valerate (Betnovate)
  • BetaMethasone Valerate, Micronized USP
  • Deviphos
  • Phosphanylidenezinc zinc
  • Valison
  • [(8S,9R,10S,11S,13S,14S,16S,17R)-9-fluoro-11-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] pentanoate
  • [(8S,9R,10S,11S,13S,14S,16S,17R)-9-fluoro-11-hydroxy-17-(2-hydroxyethanoyl)-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] pentanoate
  • valeric acid [(8S,9R,10S,11S,13S,14S,16S,17R)-9-fluoro-17-glycoloyl-11-hydroxy-3-keto-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] ester
  • Betamethasone 17-valerate,1,4-Pregnadiene-11β,17α,21-triol-9α-fluoro-16β-methyl-3,20-dione 17-valerate, 9α-Fluoro-16β-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione 17-valerate, 9α-Fluoro-16β
  • Betamethasone Valerate (200 mg)
  • Betamethasone Valerate (200 mg)K0C3300.997mg/mg(ai)
  • Betamethasone 17-val
  • BetaMethasone valerate (Betnovate, Celestone)
  • (11β,16β)-9-Fluoro-11,21-dihydroxy-16-Methyl-17-[(1-oxopentyl)oxy]pregna-1,4-diene-3,20-dione
  • 9α-Fluo
  • 9α-Fluoro-16β-Methylprednisolone 17-Valerate
  • (8S,9R,10S,11S,13S,14S,16S,17R)-9-fluoro-11-hydroxy-17-(2-hydroxyacetyl)-10,13,16-triMethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl pentanoate
  • BetaMethasone valerate 17-
  • betnovateat
  • celestoderm
  • 1,4-PREGNADIEN-9-ALPHA-FLUORO-16-BETA-METHYL-11-BETA, 17,21-TRIOL-3,20-DIONE 17-VALERATE
  • BEDERMIN
  • BETNESOL-V
  • BETNEVAL
  • BETAMETHASONE 17ALPHA-VALERATE
  • BETAMETHASONE 17A-VALERATE
  • BETAMETHASONE 17-VALERATE
  • BETAMETHASONEVALERATE,MICRONIZEDPOWDER,USP
  • 9α-Fluoro-11β,21-dihydroxy-16β-methyl-17α-valeryloxypregna-1,4-diene-3,20-dione
  • Beta-Val
  • Betoid
  • Bextasol
  • Celestan V
  • Celestane V
  • Celestoderm V
  • Celeston valerate
  • Dermosol
  • Dermovaleas
  • Ecoval 70
  • Pregna-1,4-diene-3,20-dione, 9-fluoro-11β,17,21-trihydroxy-16β-methyl-, 17-valerate (7CI, 8CI)
  • Rinderon V
  • Stanoval
  • Tokuderm
  • Valeric acid, 17-ester with 9-fluoro-11β,17,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione (8CI)
  • betamethasone pentanoate
  • 1,4-pregnadiene-11β,17α,21-triol-9α-fluoro-16β-methyl-3,20-dione 17-valerate
  • BETAMETHASONE 17-VALERATE VETRANAL, 250
  • BETAMETHASONE 17-VALERATE BP USP
  • BETAMETHASONE VALERATE BP STANDARD(CRM STANDARD)
  • BETAMETHASONE VALERATE USP(CRM STANDARD)
  • BETAMETHASONE VALERATE WHO(CRM STANDARD)
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