ACPT-I
- CAS No.
- 194918-76-8
- Chemical Name:
- ACPT-I
- Synonyms
- ACPT-I;ACPT I,ACPTI;(1S,3R,4S)-1-AMINOCYCLOPENTANE-1,3,4-TRICARBOXYLIC ACID;4-AMINO-1BETA,2BETA,4BETA-CYCLOPENTANETRICARBOXYLIC ACID;1,2,4-Cyclopentanetricarboxylic acid, 4-amino-, (1α,2α,4β)-
- CBNumber:
- CB6768791
- Molecular Formula:
- C8H11NO6
- Molecular Weight:
- 217.18
- MDL Number:
- MFCD06795869
- MOL File:
- 194918-76-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| ACPT-I ≥98% | 78010 | 1mg | $49 |
| ACPT-I ≥98% | 78010 | 5mg | $143 |
| ACPT-I ≥98% | 78010 | 10mg | $259 |
| ACPT-I ≥98% | 78010 | 25mg | $587 |
| ACPT-I ≥98% | 78010 | 1mg | $44 |
ACPT-I price More Price(25)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 78010 | ACPT-I ≥98% | 194918-76-8 | 1mg | $49 | 2026-04-30 | Buy |
| Cayman Chemical | 78010 | ACPT-I ≥98% | 194918-76-8 | 5mg | $143 | 2026-04-30 | Buy |
| Cayman Chemical | 78010 | ACPT-I ≥98% | 194918-76-8 | 10mg | $259 | 2026-04-30 | Buy |
| Cayman Chemical | 78010 | ACPT-I ≥98% | 194918-76-8 | 25mg | $587 | 2026-04-30 | Buy |
| Cayman Chemical | 78010 | ACPT-I ≥98% | 194918-76-8 | 1mg | $44 | 2024-03-01 | Buy |
ACPT-I Chemical Properties,Uses,Production
Description
ACPT-I is an agonist of the group III metabotropic glutamate receptors (mGluRs) mGluR4a and mGluR8 (EC50s = 7.2 and 8.2 μM, respectively) that has no effect on mGluR1a or mGluR2. It has diverse biological activity, including neuroprotective, anticonvulsant, and anxiolytic-like effects. ACPT-I (1-200 μM) reduces cell death following oxygen-glucose deprivation in primary neuronal cultures and in a rat model of middle cerebral artery occlusion when used at a dose of 30 mg/kg. It is neuroprotective against excitotoxicity induced by kainite in vitro and in vivo and reduces the incidence of clonic seizures in various seizure models in mice and rats (ED50s = 0.08-49.3 nM, i.c.v.). ACPT-I also has anxiolytic-like effects in mice and rats, however, these effects can be blocked by WAY-100635 and flumazenil , indicating the involvement of the serotonin (5-HT) receptor subtype 5-HT1A and GABAA receptor.
Uses
ACPT-I is a competitive antagonist for metabotropic receptors (mGluRs).
Biological Activity
Agonist for group III mGlu receptors (EC 50 values are 7.2 and 8.2 μ M for mGlu 4a and mGlu 8 respectively). Anticonvulsant in mice.
storage
Desiccate at -20°C
References
[1] FRANCINE C. ACHER. Synthesis and Pharmacological Characterization of Aminocyclopentanetricarboxylic Acids: New Tools to Discriminate between Metabotropic Glutamate Receptor Subtypes[J]. Journal of Medicinal Chemistry, 1997, 40 19: 3119-3129. DOI: 10.1021/jm970207b
[2] HELENA DOMIN . Neuroprotective potential of the group III mGlu receptor agonist ACPT-I in animal models of ischemic stroke: In vitro and in vivo studies[J]. Neuropharmacology, 2016, 102: Pages 276-294. DOI: 10.1016/j.neuropharm.2015.11.025
[3] HELENA DOMIN. Group III mGlu receptor agonist, ACPT-I, exerts potential neuroprotective effects in vitro and in vivo.[J]. Neurotoxicity Research, 2014, 26 1: 99-113. DOI: 10.1007/s12640-013-9455-7
[4] ASTRID G CHAPMAN. Anticonvulsant activity of a mGlu4α receptor selective agonist, (1S,3R,4S)-1-aminocyclopentane-1,2,4-tricarboxylic acid[J]. European journal of pharmacology, 2001, 424 2: Pages 107-113. DOI: 10.1016/s0014-2999(01)01013-5
[5] K. STACHOWICZ . The group III mGlu receptor agonist ACPT-I exerts anxiolytic-like but not antidepressant-like effects, mediated by the serotonergic and GABA-ergic systems[J]. Neuropharmacology, 2009, 57 3: Pages 227-234. DOI: 10.1016/j.neuropharm.2009.06.005
ACPT-I Preparation Products And Raw materials
ACPT-I Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32466 | 58 |
| BOC Sciences | 16314854226; +16314854226 | inquiry@bocsci.com | United States | 19853 | 58 |
| NANJING YINGWEN BIOTECHNOLOGY CO LTD | +8613382787392 | sales@aeechem.com | China | 10001 | 58 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15838 | 69 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8447 | 60 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9804 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11218 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8140 | 58 |
| Beijing Biocreative Technology Co., Ltd. | 15522676233 | 3007606172@qq.com | China | 1248 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24955 | 58 |
