CIPROXIFAN
- CAS No.
- 184025-19-2
- Chemical Name:
- CIPROXIFAN
- Synonyms
- CS-109;CIPROXIFAN;FUB359 Maleate;FUB-359 Maleate;FUB 359 Maleate;Ciproxifan Moleate;FUB 359 Maleate salt;Ciproxifan maleate, >=98%;Ciproxifan Maleate (FUB-359);Ciproxifan maleate, 10 mM in DMSO
- CBNumber:
- CB6972679
- Molecular Formula:
- C16H18N2O2.C4H4O4
- Molecular Weight:
- 386.402
- MDL Number:
- MFCD06411563
- MOL File:
- 184025-19-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Ciproxifan maleate ≥98% (HPLC), powder | C6848 | 5mg | $197 |
| Ciproxifan maleate ≥98% (HPLC), powder | C6848 | 25mg | $686 |
| Ciproxifan (maleate) ≥98% | 29513 | 1mg | $37 |
| Ciproxifan (maleate) ≥98% | 29513 | 5mg | $132 |
| Ciproxifan (maleate) ≥98% | 29513 | 10mg | $246 |
| More product size | |||
| storage temp. | Store at -20°C |
|---|---|
| solubility | DMSO: soluble32mg/mL |
| form | powder |
| color | white to beige |
| InChI | 1S/C16H18N2O2.C4H4O4/c19-16(12-3-4-12)13-5-7-15(8-6-13)20-9-1-2-14-10-17-11-18-14;5-3(6)1-2-4(7)8/h5-8,10-12H,1-4,9H2,(H,17,18);1-2H,(H,5,6)(H,7,8)/b;2-1- |
| InChIKey | RLQFKEYRALXXEJ-BTJKTKAUSA-N |
| SMILES | OC(=O)\C=C/C(O)=O.O=C(C1CC1)c2ccc(OCCCc3c[nH]cn3)cc2 |
| FDA UNII | 5EVQ7IRG99 |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H317-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P280-P301+P312-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Faceshields, Gloves | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22-36/37/38-43 | |||||||||
| Safety Statements | 26-36/37/39 | |||||||||
| WGK Germany | 3 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral Eye Irrit. 2 Skin Irrit. 2 Skin Sens. 1 STOT SE 3 |
|||||||||
| NFPA 704 |
|
CIPROXIFAN price More Price(57)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | C6848 | Ciproxifan maleate ≥98% (HPLC), powder | 184025-19-2 | 5mg | $197 | 2026-04-30 | Buy |
| Sigma-Aldrich | C6848 | Ciproxifan maleate ≥98% (HPLC), powder | 184025-19-2 | 25mg | $686 | 2026-04-30 | Buy |
| Cayman Chemical | 29513 | Ciproxifan (maleate) ≥98% | 184025-19-2 | 1mg | $37 | 2026-04-30 | Buy |
| Cayman Chemical | 29513 | Ciproxifan (maleate) ≥98% | 184025-19-2 | 5mg | $132 | 2026-04-30 | Buy |
| Cayman Chemical | 29513 | Ciproxifan (maleate) ≥98% | 184025-19-2 | 10mg | $246 | 2026-04-30 | Buy |
CIPROXIFAN Chemical Properties,Uses,Production
Description
Ciproxifan is a histamine H3 receptor antagonist (Ki = 0.5 nM for inhibition of histamine release in rat synaptosomal preparations). It is selective for histamine H3 over histamine H1 and H2, M3 muscarinic, and α1D- and β1-adrenergic receptors (Kis = 3.15-25 μM), as well as the serotonin (5-HT) receptor subtypes 5-HT1B, 5-HT2A, 5-HT3, and 5-HT4 (Kis = 1.58-15 μM) in radioligand binding assays. Ciproxifan (3-300 nM) inhibits relaxation in precontracted isolated guinea pig ileal longitudinal muscle induced by R-(–)-α-methylhistamine . In vivo, ciproxifan reduces R-(–)-α-methylhistamine-induced water consumption in rats (ED50 = 0.09 mg/kg). It increases wake episode duration and latency to fall asleep in rats when administered at a dose of 2 mg/kg.
Uses
Ciproxifan is a potent histamine H3 receptor antagonist which affects histamine levels in the brain. It may be used in treatments for sleep and neurological disorders.
Biochem/physiol Actions
Potent, selective H3 histamine receptor antagonist.
in vivo
Ciproxifan (1 mg/kg; a single p.o.) increases the t-MeHA level in mouse brain, with an ED50 of 0.14 mg/kg[1].
Ciproxifan (3 mg/kg, i.p.) improves the accuracy of responding in the five-choice task in rats only when the stimulus duration is 0.25 sec instead of 0.50 sec[1].
Ciproxifan (0.15-2 mg/kg; p.o.) induces marked signs of neocortical electroencephalogram activation manifested by enhanced fast-rhythms density and an almost total waking state in cats[1].
Ciproxifan (1 mg/kg; a single i.v.) decreases the H3-receptor ligand concentration in serum in mice, with the half-lives (t1/2) of 13 and 87 min for the distribution and elimination phases in mice, respectively[1].
Ciproxifan (1 mg/kg; a single p.o.) exhibits oral bioavailability (F=62%) and maximal concentration (Cmax=420 nM) in mice[1].
IC 50
H3 receptor: 9.2 nM (IC50)
References
[1] X LIGNEAU. Neurochemical and behavioral effects of ciproxifan, a potent histamine H3-receptor antagonist.[J]. Journal of Pharmacology and Experimental Therapeutics, 1998, 287 2: 658-666.
CIPROXIFAN Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19936 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29792 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32466 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6312 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471; | sales@sarms4muscle.com | China | 10473 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 | market18@leapchem.com | China | 24597 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8467 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +86-18621343501; +undefined18621343501 | product@acmec-e.com | China | 33324 | 58 |
View Lastest Price from CIPROXIFAN manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-05-11 | Ciproxifan maleate
184025-19-2
|
$73.00-227.00 | 99.45% | 10g | TargetMol Chemicals Inc. | ||
![(Z)-but-2-enedioic acid,cyclopropyl-[4-[3-(1H-imidazol-5-yl)propoxy]phenyl]methanone pictures](https://img.chemicalbook.com/ProductImageEN/2020-1/Small/0b8f8145-1465-456c-a39d-23d73ba9c90d.png) |
2020-01-02 | (Z)-but-2-enedioic acid,cyclopropyl-[4-[3-(1H-imidazol-5-yl)propoxy]phenyl]methanone
184025-19-2
|
$1.00 | 1KG | Min98% HPLC | Career Henan Chemical Co |
-
- Ciproxifan maleate
184025-19-2
- $73.00-227.00
- 99.45%
- TargetMol Chemicals Inc.
-
- (Z)-but-2-enedioic acid,cyclopropyl-[4-[3-(1H-imidazol-5-yl)propoxy]phenyl]methanone
184025-19-2
- $1.00
- Min98% HPLC
- Career Henan Chemical Co
