Cefoperazon
|
|
|
- CAS-Nr.
- 62893-19-0
- Bezeichnung:
- Cefoperazon
- Englisch Name:
- Cefoperazone
- Synonyma:
- CEFOPERAZONE ACID;Cefoperazone (Cefobid);(6R,7R)-7-((R)-2-(4-ethyl-2,3-dioxopiperazine-1-carboxamido)-2-(4-hydroxyphenyl)acetamido)-3-(((1-methyl-1H-tetrazol-5-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid,7-[[(2R)-2-[[(4-ethyl-2,3-dioxo-1-piperazinyl)carbonyl]aMino]-2-(4-hydroxyphenyl)acetyl]aMino]-3-[[(1-Methyl-1H-tetrazol-5-yl)thio]Methyl]-8-oxo-,(6R,7R)-;Cefob;l~rdum;Medocef;CEFOPERAZONE;cefoperazine;Cephaperazon
- CBNumber:
- CB4752040
- Summenformel:
- C25H27N9O8S2
- Molgewicht:
- 645.67
- MOL-Datei:
- 62893-19-0.mol
|
Cefoperazon Eigenschaften
- Schmelzpunkt:
- 169-171 C
- Dichte
- 1.77±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- L?slichkeit
- DMSO (Slightly, Sonicated), Methanol (Slightly, Heated, Sonicated)
- Aggregatzustand
- Solid
- pka
- pKa 2.6 (Uncertain)
- Farbe
- White to Off-White
- Merck
- 14,1930
- InChIKey
- GCFBRXLSHGKWDP-XCGNWRKASA-N
- SMILES
- N12[C@@]([H])([C@H](NC([C@H](NC(N3CCN(CC)C(=O)C3=O)=O)C3=CC=C(O)C=C3)=O)C1=O)SCC(CSC1N(C)N=NN=1)=C2C(O)=O
- CAS Datenbank
- 62893-19-0(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
|
| Alarmwort |
Warnung
|
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
|
P264, P270, P301+P312, P330, P501 |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
|
P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
|
P264, P280, P305+P351+P338,P337+P313P |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
|
|
|
| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
|
Cefoperazon Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R20/21/22:Gesundheitssch?dlich beim Einatmen,Verschlucken und Berührung mit der Haut.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-S?tze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
Cefoperazone has a C-7 side chain reminiscent of piperacillin's and also possesses the C-3 side chain
(MTT ) that often is associated with the bleeding and alcohol intolerance problems among patients taking
cephalosporins. Its useful activity against pseudomonads partly compensates for this, although it is not
potent enough to be used as a single agent against this difficult pathogen. The C-7 side chain does not
convey sufficient resistance to many β-lactamases, although the addition of clavulanic acid or sulbactam
would presumably help.
Chemische Eigenschaften
white crystals
Verwenden
Cefoperazone also has a broad spectrum of antimicrobial action, including most clinically
significant microorganisms: Gram-positive, Gram-negative, aerobic, and anaerobic. It is
stable with respect to most beta-lactamases of Gram-positive and Gram-negative bacteria.
Cefoperazone is used for bacterial infections of the lower respiratory tract, urinary and
sexual tracts, bones, joints, skin, soft tissues, abdominal, and gynecological infections.
Synonyms of this drug are cefazon, cefobid, cefobis, and many others.
Definition
ChEBI: A semi-synthetic parenteral cephalosporin with a tetrazolyl moiety that confers beta-lactamase resistance.
Cefoperazon Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Cefoperazon Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 370)Lieferanten
62893-19-0(Cefoperazon)Verwandte Suche:
- (6R,7R)-7-{[(2S)-2-{[(4-ETHYL-2,3-DIOXO-1-PIPERAZINYL)CARBONYL]AMINO}-2-(4-HYDROXYPHENYL)ACETYL]AMINO}-3-{[(1-METHYL-1H-TETRAZOL-5-YL)SULFANYL]METHYL}-8-OXO-5-THIA-1-AZABICYCLO[4.2.0]OCT-2-ENE-2-CARBO XYLIC ACID
- CEFOPERAZONE
- (6R,7R)-7-[[(2R)-2-[[(4-ethyl-2,3-dioxo-1-piperazinyl)carbonyl]amino]-2-(4-hydroxyphenyl)acetyl]amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
- (6r-(6-alpha,7-beta(r*)))--tetrazol-5-yl)thio)methyl)-8-oxo
- -1-piperazinyl)carbonyl)amino)(4-hydroxyphenyl)acetyl)amino)-3-(((1-methyl-1h
- cefoperazine
- Cefobis：Cefogram
- l~rdum
- Perocef：Tomabef
- Cefoperazone Dihydrate (200 mg)
- 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2R)-[[(4-ethyl-2,3-dioxo-1-piperazinyl)carbonyl]amino](4-hydroxyphenyl)acetyl]amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-, (6R,7R)-
- 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[[[(4-ethyl-2,3-dioxo-1-piperazinyl)carbonyl]amino](4-hydroxyphenyl)acetyl]amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-, [6R-[6α,7β(R*)]]-
- Cefob
- Cephaperazon
- Medocef
- Cefoperazone (base and/or unspecified salts)
- Cefoperazone SodiuM IMp. B
- Cefoperazone free acid
- [6R-[6alpha,7beta(R*)]]-7-[[[[(4-Ethyl-2,3-dioxo-1- piperazinyl)carbonyl]amino](4-hydroxyphenyl)acetyl]amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
- (6S,7S)-7-[[2-[[(4-ethyl-2,3-dioxo-1-piperazinyl)-oxomethyl]amino]-2-(4-hydroxyphenyl)-1-oxoethyl]amino]-3-[[(1-methyl-5-tetrazolyl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic
- Cefoperazone dihydrate CRS
- Cefoperazone USP/EP/BP
- Cefoperazoner
- Cefoperazone acid, Pharma
- Cefoperazone (Cefobid)
- (6R,7R)-7-((R)-2-(4-ethyl-2,3-dioxopiperazine-1-carboxamido)-2-(4-hydroxyphenyl)acetamido)-3-(((1-methyl-1H-tetrazol-5-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
- Trolamine Impurity 5
- Cefoperazone in methanol
- Cefoperazone, 10 mM in DMSO
- Cefoperazone RS
- Cefoperazone 1000 μg/mL in Acetonitrile
- 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid,7-[[(2R)-2-[[(4-ethyl-2,3-dioxo-1-piperazinyl)carbonyl]aMino]-2-(4-hydroxyphenyl)acetyl]aMino]-3-[[(1-Methyl-1H-tetrazol-5-yl)thio]Methyl]-8-oxo-,(6R,7R)-
- CEFOPERAZONE ACID
- 62893-19-0
- 62893-12-0
- C25H27N9O8S2
- Inhibitors
- Pharmaceutical
