4-Benzofurancarboxylic Acid
- CAS No.
- 166599-84-4
- Chemical Name:
- 4-Benzofurancarboxylic Acid
- Synonyms
- Degarelix Impurity 1;4-BENZOFURANCARBOXYLICACID;benzofuran-4-carboxylic acid;1-benzofuran-4-carboxylicaci;1-Benzofuran-4-carboxylic acid;1-benzofurane-4-carboxylic acid;4-Benzofurancarboxylic Acid ISO 9001：2015 REACH
- CBNumber:
- CB71094180
- Molecular Formula:
- C9H6O3
- Molecular Weight:
- 162.14
- MDL Number:
- MFCD10000600
- MOL File:
- 166599-84-4.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 4-Benzofurancarboxylic Acid | RGA59984 | 0.5g | $395.3 |
| 4-Benzofurancarboxylic Acid | RGA59984 | 5g | $1770 |
| 4-Benzofurancarboxylic acid | 123707 | 250.00mg | $61 |
| 4-Benzofurancarboxylic acid | 123707 | 1.00g | $213 |
| 4-Benzofurancarboxylic acid | 123707 | 5.00g | $779 |
| More product size | |||
| Boiling point | 326℃ |
|---|---|
| Density | 1.363 |
| Flash point | 151℃ |
| storage temp. | Sealed in dry,Room Temperature |
| pka | 3.19±0.10(Predicted) |
| Appearance | White to off-white Solid |
| InChI | InChI=1S/C9H6O3/c10-9(11)7-2-1-3-8-6(7)4-5-12-8/h1-5H,(H,10,11) |
| InChIKey | WFAPIZKLEVLUMX-UHFFFAOYSA-N |
| SMILES | O1C2=CC=CC(C(O)=O)=C2C=C1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
4-Benzofurancarboxylic Acid price More Price(40)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | RGA59984 | 4-Benzofurancarboxylic Acid | 166599-84-4 | 0.5g | $395.3 | 2026-06-05 | Buy |
| Biosynth | RGA59984 | 4-Benzofurancarboxylic Acid | 166599-84-4 | 5g | $1770 | 2026-06-05 | Buy |
| Matrix Scientific | 123707 | 4-Benzofurancarboxylic acid | 166599-84-4 | 250.00mg | $61 | 2026-05-18 | Buy |
| Matrix Scientific | 123707 | 4-Benzofurancarboxylic acid | 166599-84-4 | 1.00g | $213 | 2026-05-18 | Buy |
| Matrix Scientific | 123707 | 4-Benzofurancarboxylic acid | 166599-84-4 | 5.00g | $779 | 2026-05-18 | Buy |
4-Benzofurancarboxylic Acid Chemical Properties,Uses,Production
Uses
4-Benzofurancarboxylic Acid is a benzofuran derivative used in the preparation of dual orexin 1 and orexin 2 receptor antagonist which are useful for the treatment of sleep disorders.
Synthesis
41019-56-1
166599-84-4
General procedure for the synthesis of benzofuran-4-carboxylic acid from methyl benzofuran-4-carboxylate: a solution of LiOH (1.44 g, 34.3 mmol) in water (20 mL) was added to a mixture of THF (20 mL) and MeOH (20 mL) of methyl benzofuran-4-carboxylate (2.02 g, 11.4 mmol) and the reaction was stirred at room temperature for 16 The reaction was stirred for 16 hours at room temperature. After completion of the reaction, the solvent was removed by evaporation. The residue was dissolved in water (50 mL) and acidified with concentrated HCl to pH < 2. The precipitate was collected by filtration and dried to afford benzofuran-4-carboxylic acid (1.83 g, 99% yield). The product was characterized by 1H NMR (DMSO-d6): δ 13.10 (s, 1H), 8.14 (d, J = 2.1 Hz, 1H), 7.85-7.91 (m, 2H), 7.43 (t, J = 7.9 Hz, 1H), 7.33 (dd, J = 2.1, 1.0 Hz, 1H). Mass spectrum measured value: [M-H] = 161.1.
References
[1] Patent: WO2017/155909, 2017, A1. Location in patent: Paragraph 0190
[2] Bioorganic and Medicinal Chemistry, 2018, vol. 26, # 8, p. 1797 - 1809
[3] Journal of Medicinal Chemistry, 1995, vol. 38, # 16, p. 3094 - 3105
4-Benzofurancarboxylic Acid Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29626 | 60 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63645 | 58 |
| career henan chemical co | +86-0371-86658258 | factory@coreychem.com | China | 29780 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1059@dideu.com | China | 29096 | 58 |
| Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 | shawn@hirisunpharm.com | CHINA | 9897 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 17705817739 | info@dycnchem.com | China | 52693 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418684 +86-18949823763 | sales@tnjchem.com | China | 25333 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 +8619957148339 | market18@leapchem.com | China | 24569 | 58 |
| Aromsyn Co., Ltd. | +86-0571-85585865 +86-13336024896 | CB@aromsyn.com | China | 19176 | 58 |
| PT CHEM GROUP LIMITED | +86-85511178; +86-85511178 | peter68@ptchemgroup.com | China | 35405 | 58 |
View Lastest Price from 4-Benzofurancarboxylic Acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-11-18 | 4-Benzofurancarboxylic Acid
166599-84-4
|
$1.10 | 1g | 99.0% Min | 100 Tons | Dideu Industries Group Limited | |
 |
2024-02-19 | Benzofuran-4-carboxylic acid
166599-84-4
|
$890.00 | 1g | 96 | 500 Kg | R&D Scientific Inc. | |
 |
2020-02-26 | 4-Benzofurancarboxylic Acid
166599-84-4
|
5g | 99%+ | 100 tons | Shaanxi Dideu Medichem Co. Ltd |
-
- 4-Benzofurancarboxylic Acid
166599-84-4
- $1.10
- 99.0% Min
- Dideu Industries Group Limited
-
- Benzofuran-4-carboxylic acid
166599-84-4
- $890.00
- 96
- R&D Scientific Inc.
-
- 4-Benzofurancarboxylic Acid
166599-84-4
- 99%+
- Shaanxi Dideu Medichem Co. Ltd
