Bipenquinate
- CAS No.
- 96201-88-6
- Chemical Name:
- Bipenquinate
- Synonyms
- Brequinar sodium;CS-340;Dup-785;NSC-368390;Bipenquinate;Brequinar sodium (DuP-785;Bipenquinate, 10 mM in DMSO;Brequinar (Synonyms: DUP785;Dihydroorotate Dehydrogenase Inhibitor, Brequinar;6-fluoro-2-[4-(2-fluorophenyl)phenyl]-3-methylquinoline-4-carboxylate
- CBNumber:
- CB71178121
- Molecular Formula:
- C23H14F2NNaO2
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- 96201-88-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Dihydroorotate Dehydrogenase Inhibitor, Brequinar | 5.08321 | 10mg | $224 |
| Brequinar (sodium salt) ≥98% | 36183 | 10mg | $74 |
| Brequinar (sodium salt) ≥98% | 36183 | 50mg | $329 |
| Brequinar (sodium salt) ≥98% | 36183 | 100mg | $585 |
| Brequinar Sodium | TRC-B677455-5MG | 5mg | $94 |
| More product size | |||
| Melting point | >360° |
|---|---|
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | Soluble in DMSO (up to at least 25 mg/ml) or in Water (up to 15 mg/ml with warming) |
| form | solid |
| color | Off-white or white |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 1 month. |
| InChI | 1S/C23H15F2NO2.Na/c1-13-21(23(27)28)18-12-16(24)10-11-20(18)26-22(13)15-8-6-14(7-9-15)17-4-2-3-5-19(17)25;/h2-12H,1H3,(H,27,28);/q;+1/p-1 |
| InChIKey | PZOHOALJQOFNTB-UHFFFAOYSA-M |
| SMILES | [Na+].Fc1c(cccc1)c2ccc(cc2)c3nc4c(c(c3C)C(=O)[O-])cc(cc4)F |
| FDA UNII | 49EEF6HRUS |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| WGK Germany | WGK 3 |
| Storage Class | 11 - Combustible Solids |
Bipenquinate price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 5.08321 | Dihydroorotate Dehydrogenase Inhibitor, Brequinar | 96201-88-6 | 10mg | $224 | 2026-04-30 | Buy |
| Cayman Chemical | 36183 | Brequinar (sodium salt) ≥98% | 96201-88-6 | 10mg | $74 | 2026-04-30 | Buy |
| Cayman Chemical | 36183 | Brequinar (sodium salt) ≥98% | 96201-88-6 | 50mg | $329 | 2026-04-30 | Buy |
| Cayman Chemical | 36183 | Brequinar (sodium salt) ≥98% | 96201-88-6 | 100mg | $585 | 2026-04-30 | Buy |
| TRC | TRC-B677455-5MG | Brequinar Sodium | 96201-88-6 | 5mg | $94 | 2026-06-03 | Buy |
Bipenquinate Chemical Properties,Uses,Production
Description
Brequinar sodium (96201-88-6) is an inhibitor of dihydroorotate dehydrogenase (DHODH)1,2with IC50’s between 0.2 and 5.8 μM in various cell lines3and 20 nM in isolated enzyme4. It reduced leukemic cell burden, decreased levels of leukemia-initiating cells, and improved survival in human and mouse models of acute myeloid leukemia.4Brequinar displayed broad antiviral activity against flaviviruses, positive-strand RNA alphaviruses, negative-strand RNA rhabdoviruses, Influenza A and B viruses, and HIV.5-7
Uses
Antineoplastic.
Definition
ChEBI: Brequinar sodium is an organic sodium salt of brequinar. It has a role as an anticoronaviral agent, an antineoplastic agent, an antiviral agent, an EC 1.3.5.2 [dihydroorotate dehydrogenase (quinone)] inhibitor, an immunosuppressive agent, a pyrimidine synthesis inhibitor and an antimetabolite. It contains a brequinar(1-).
storage
Store at +4°C
References
[1] S F CHEN D L D R L Ruben. Mechanism of action of the novel anticancer agent 6-fluoro-2-(2’-fluoro-1,1’-biphenyl-4-yl)-3-methyl-4-quinolinecarbo xylic acid sodium salt (NSC 368390): inhibition of de novo pyrimidine nucleotide biosynthesis.[J]. Cancer research, 1986, 46 10: 5014-5019.
[2] G J PETERS. In vivo inhibition of the pyrimidine de novo enzyme dihydroorotic acid dehydrogenase by brequinar sodium (DUP-785; NSC 368390) in mice and patients.[J]. Cancer research, 1990, 50 15: 4644-4649.
[3] E. DE KANT. The relation between inhibition of cell growth and of dihydroorotic acid dehydrogenase by Brequinar Sodium[J]. Cancer letters, 1989, 46 2: Pages 123-127. DOI:10.1016/0304-3835(89)90019-0
[4] D. SYKES. Inhibition of Dihydroorotate Dehydrogenase Overcomes Differentiation Blockade in Acute Myeloid Leukemia[J]. Cell, 2016, 167 1: 171-186.e15. DOI:10.1016/j.cell.2016.08.057
[5] MIN QING. Characterization of dengue virus resistance to brequinar in cell culture.[J]. Antimicrobial Agents and Chemotherapy, 2010: 3686-3695. DOI:10.1128/aac.00561-10
[6] PETTER I. ANDERSEN. Novel Antiviral Activities of Obatoclax, Emetine, Niclosamide, Brequinar, and Homoharringtonine[J]. Viruses-Basel, 2019. DOI:10.3390/v11100964
[7] JUN-GYU PARK. Identification and Characterization of Novel Compounds with Broad-Spectrum Antiviral Activity against Influenza A and B Viruses.[J]. Journal of Virology, 2020. DOI:10.1128/jvi.02149-19
Bipenquinate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 965 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32466 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30224 | 58 |
| BOC Sciences | 16314854226; +16314854226 | inquiry@bocsci.com | United States | 19853 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| Nanjing Doge Biomedical Technology Co., Ltd | +86-25-58227606 +86-15305155328 | sales@dogechemical.com | China | 4128 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39039 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 | market18@leapchem.com | China | 43333 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +86-18621343501; +undefined18621343501 | product@acmec-e.com | China | 33324 | 58 |
View Lastest Price from Bipenquinate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-04-22 | Brequinar sodium
96201-88-6
|
$60.00-181.00 | 98.16% | 10g | TargetMol Chemicals Inc. |
-
- Brequinar sodium
96201-88-6
- $60.00-181.00
- 98.16%
- TargetMol Chemicals Inc.
