2-Bromo-5-fomylthiazole
- CAS No.
- 464192-28-7
- Chemical Name:
- 2-Bromo-5-fomylthiazole
- Synonyms
- 4-BROMOTHIAZOLE-2-CARBALDEHYDE;2-broMo-1,3-thiazole-5-carbaldehyde;CAS:464192-28-7;2-Bromo-5-formyL;2-Bromo-5-fomylthiazole;2-BROMO-5-FORMYLTHIAZOLE;2-Bromo-5-formyl-1,3-thiazole;2-Bromo-5-formylthiazole ,98%;2-Bromo-5-thiazolecarbaldehyde;2-Bromothiazole-5-carboxaldehy
- CBNumber:
- CB7119756
- Molecular Formula:
- C4H2BrNOS
- Molecular Weight:
- 192.03
- MDL Number:
- MFCD03788567
- MOL File:
- 464192-28-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 2-Bromothiazole-5-carboxaldehyde 97% | 756865 | 500mg | $121 |
| 2-Bromo-5-formylthiazole 98% | AS50070 | 1g | $21 |
| 2-Bromo-5-formylthiazole 98% | AS50070 | 5g | $55 |
| 2-Bromo-5-formylthiazole 98% | AS50070 | 25g | $256 |
| 2-Bromo-5-formylthiazole 98% | AS50070 | 100g | $948 |
| More product size | |||
| Melting point | 94-96°C |
|---|---|
| Boiling point | 264.9±13.0 °C(Predicted) |
| Density | 1.920±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| form | Crystalline Powder |
| pka | -0.94±0.10(Predicted) |
| color | White to yellow |
| InChI | InChI=1S/C4H2BrNOS/c5-4-6-1-3(2-7)8-4/h1-2H |
| InChIKey | DJUWIZUEHXRECB-UHFFFAOYSA-N |
| SMILES | S1C(C=O)=CN=C1Br |
| CAS DataBase Reference | 464192-28-7(CAS DataBase Reference) |
| UNSPSC Code | 12352200 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H317-H319 | |||||||||
| Precautionary statements | P261-P264-P280-P301+P312-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 36/37/38-43-36-22 | |||||||||
| Safety Statements | 26-36/37/39-36/37 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Irritant | |||||||||
| HS Code | 29339900 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral Eye Irrit. 2 Skin Sens. 1 |
|||||||||
| NFPA 704 |
|
2-Bromo-5-fomylthiazole price More Price(70)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 756865 | 2-Bromothiazole-5-carboxaldehyde 97% | 464192-28-7 | 500mg | $121 | 2023-06-20 | Buy |
| Activate Scientific | AS50070 | 2-Bromo-5-formylthiazole 98% | 464192-28-7 | 1g | $21 | 2026-06-04 | Buy |
| Activate Scientific | AS50070 | 2-Bromo-5-formylthiazole 98% | 464192-28-7 | 5g | $55 | 2026-06-04 | Buy |
| Activate Scientific | AS50070 | 2-Bromo-5-formylthiazole 98% | 464192-28-7 | 25g | $256 | 2026-06-04 | Buy |
| Activate Scientific | AS50070 | 2-Bromo-5-formylthiazole 98% | 464192-28-7 | 100g | $948 | 2026-06-04 | Buy |
2-Bromo-5-fomylthiazole Chemical Properties,Uses,Production
Chemical Properties
Yellow powder
Uses
2-Bromothiazole-5-carboxaldehyde is a reactant in the preparation of thienopyridines as potent checkpoint 1 kinase (CHK1) inhibitors.
Synthesis
687636-93-7
464192-28-7
General procedure for the synthesis of 2-bromo-5-formylthiazole from 2-bromothiazole-5-methanol: Manganese dioxide (3.8 g, 37.10 mmol) was added to a solution of 2-bromothiazole-5-methanol (1.44 g, 7.42 mmol) in trichloromethane (20 mL). The reaction mixture was stirred at room temperature for 3 days. Upon completion of the reaction, the mixture was filtered through diatomaceous earth and the filtrate was concentrated under reduced pressure to give 2-bromo-5-formylthiazole (870 mg, 61% yield) as a white solid. The structure of the product was confirmed by nuclear magnetic resonance hydrogen spectrum (1H-NMR, 400 MHz, CDCl3): δ 9.95 (s, 1H), 8.16 (s, 1H); nuclear magnetic resonance carbon spectrum (13C-NMR, 100 MHz, CDCl3): δ 180.93, 150.47, 145.48, 142.91; mass spectra (ESI): m/z 192.31 ([MH+]).
References
[1] Patent: WO2008/61795, 2008, A2. Location in patent: Page/Page column 61-62
2-Bromo-5-fomylthiazole Preparation Products And Raw materials
Raw materials
1of3
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10821 | 58 |
| CONIER CHEM AND PHARMA LIMITED | sales@conier.com | China | 49979 | 58 | |
| career henan chemical co | +86-0371-86658258 | factory@coreychem.com | China | 29792 | 58 |
| Hubei Ipure Biology Co., Ltd | +8618062405514 | ada@ipurechemical.com | China | 10236 | 58 |
| HONG KONG IPURE BIOLOGY CO.,LIMITED | 86 18062405514 18062405514 | ada@ipurechemical.com | CHINA | 3461 | 58 |
| Baoji Guokang Healthchem Co., Ltd. | +86-0917-3909592 +86-13892490616 | gksales1@gk-bio.com | China | 9048 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 17705817739 | info@dycnchem.com | China | 52704 | 58 |
View Lastest Price from 2-Bromo-5-fomylthiazole manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-07-13 | 2-Bromo-5-fomylthiazole
464192-28-7
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd | ||
 |
2021-07-10 | 2-Bromo-5-fomylthiazole
464192-28-7
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd | ||
 |
2020-03-22 | 2-Bromo-5-fomylthiazole
464192-28-7
|
$1.80 | 1g | 90.0%-99.9% | 800kg | Career Henan Chemical Co |
-
- 2-Bromo-5-fomylthiazole
464192-28-7
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- 2-Bromo-5-fomylthiazole
464192-28-7
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- 2-Bromo-5-fomylthiazole
464192-28-7
- $1.80
- 90.0%-99.9%
- Career Henan Chemical Co
