4-Chloro-5-Bromopyrimidine
- CAS No.
- 56181-39-6
- Chemical Name:
- 4-Chloro-5-Bromopyrimidine
- Synonyms
- 4-Chloro-5-Bromopyrimidine;4-Chloro-5-bromopyrimidin...;Pyrimidine, 5-bromo-4-chloro-;4-Chloro-5-Bromopyrimidine ISO 9001：2015 REACH
- CBNumber:
- CB71270902
- Molecular Formula:
- C4H2BrClN2
- Molecular Weight:
- 193.43
- MDL Number:
- MFCD09750158
- MOL File:
- 56181-39-6.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 5-Bromo-4-chloropyrimidine >98% | OR902595 | 1g | $21 |
| 5-Bromo-4-chloropyrimidine >98% | OR902595 | 5g | $45 |
| 5-Bromo-4-chloropyrimidine >98% | OR902595 | 25g | $202 |
| 5-Bromo-4-chloropyrimidine >98% | OR902595 | 100g | $799 |
| 5-Bromo-4-chloropyrimidine >98% | OR902595 | 1g | $21 |
| More product size | |||
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H332-H335-H312-H302-H319-H315 |
| Precautionary statements | P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P-P261-P271-P304+P340-P312-P280-P302+P352-P312-P322-P363-P501-P264-P270-P301+P312-P330-P501 |
| HS Code | 2933599590 |
4-Chloro-5-Bromopyrimidine price More Price(64)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | OR902595 | 5-Bromo-4-chloropyrimidine >98% | 56181-39-6 | 1g | $21 | 2026-06-04 | Buy |
| Apolloscientific | OR902595 | 5-Bromo-4-chloropyrimidine >98% | 56181-39-6 | 5g | $45 | 2026-06-04 | Buy |
| Apolloscientific | OR902595 | 5-Bromo-4-chloropyrimidine >98% | 56181-39-6 | 25g | $202 | 2026-06-04 | Buy |
| Apolloscientific | OR902595 | 5-Bromo-4-chloropyrimidine >98% | 56181-39-6 | 100g | $799 | 2026-06-04 | Buy |
| Apolloscientific | OR902595 | 5-Bromo-4-chloropyrimidine >98% | 56181-39-6 | 1g | $21 | 2026-06-04 | Buy |
4-Chloro-5-Bromopyrimidine Chemical Properties,Uses,Production
Chemical Properties
Pale yellow crystal
Synthesis
19808-30-1
56181-39-6
The general procedure for the synthesis of 4-chloro-5-bromopyrimidine using 5-bromopyrimidin-4-one as starting material was as follows: to a mixture of 5-bromopyrimidin-4-ol (40 g, 0.22 mol) dissolved in POCl3 (300 mL) was added drop-wise DIPEA (29 g, 0.22 mol) at room temperature. Subsequently, the reaction mixture was heated to reflux and maintained for 3 hours. The progress of the reaction was monitored by TLC (unfolding agent ratio of petroleum ether/EtOAc 1:1) to confirm the completion of the reaction. Upon completion of the reaction, excess POCl3 was removed by distillation under reduced pressure. the residue was slowly poured into ice water (300 mL) under stirring. The aqueous phase was extracted with EtOAc (2 × 300 mL), the organic layers were combined and washed sequentially with water (300 mL) and brine (300 mL), dried over Na2SO4 and finally concentrated under vacuum. The residue was purified by silica gel column chromatography (eluent ratio of petroleum ether/EtOAc, gradient from 20:1 to 10:1) to afford the target product 5-bromo-4-chloropyrimidine (25 g, 60% yield) as a yellow oil.
References
[1] Patent: WO2016/97918, 2016, A1. Location in patent: Page/Page column 88
[2] Patent: WO2012/135631, 2012, A1. Location in patent: Page/Page column 21-22
[3] Patent: WO2010/88518, 2010, A2. Location in patent: Page/Page column 86-87
[4] Organic Process Research and Development, 2000, vol. 4, # 4, p. 275 - 285
4-Chloro-5-Bromopyrimidine Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Daken Advanced Materials Co.,Ltd | +86-2158073036 | info@dakenam.com | China | 14033 | 58 |
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3009 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Accela ChemBio Inc. | +1-858-6993322 +86-18019713315 | info@accelachem.com | United States | 21193 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Jurong Coupling Biotechnology Co., Ltd. | 13656108824 | coupling278191416@hotmail.com | CHINA | 184 | 58 |
| CONIER CHEM AND PHARMA LIMITED | sales@conier.com | China | 49979 | 58 | |
| career henan chemical co | +86-0371-86658258 | factory@coreychem.com | China | 29807 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +86-189 4982 3763 | sales@tnjchem.com | China | 34563 | 58 |
View Lastest Price from 4-Chloro-5-Bromopyrimidine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-11-18 | 4-Chloro-5-Bromopyrimidine
56181-39-6
|
$1.10 | 1g | 99.00% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2020-03-16 | 4-Chloro-5-Bromopyrimidine
56181-39-6
|
$3.00 | 1KG | 98% | 100KG | Career Henan Chemical Co |
-
- 4-Chloro-5-Bromopyrimidine
56181-39-6
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- 4-Chloro-5-Bromopyrimidine
56181-39-6
- $3.00
- 98%
- Career Henan Chemical Co
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