3-iodo-1H-pyrrolo[3,2-b]pyridine
![3-iodo-1H-pyrrolo[3,2-b]pyridine Structure](CAS/GIF/1083181-26-3.gif)
- CAS No.
- 1083181-26-3
- Chemical Name:
- 3-iodo-1H-pyrrolo[3,2-b]pyridine
- Synonyms
- 3-Iodo-4-azaindole;3-iodo-1H-pyrrolo[3,2-b]pyridine;1H-Pyrrolo[3,2-b]pyridine, 3-iodo-
- CBNumber:
- CB71515784
- Molecular Formula:
- C7H5IN2
- Molecular Weight:
- 244.03
- MDL Number:
- MFCD11559019
- MOL File:
- 1083181-26-3.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 3-Iodo-1H-pyrrolo[3,2-b]pyridine 97% | OR321324 | 250mg | $21 |
| 3-Iodo-1H-pyrrolo[3,2-b]pyridine 98% | AS39384 | 1g | $50 |
| 3-Iodo-1H-pyrrolo[3,2-b]pyridine 97% | OR321324 | 1g | $48 |
| 3-Iodo-1H-pyrrolo[3,2-b]pyridine 98% | AS39384 | 5g | $139 |
| 3-Iodo-1H-pyrrolo[3,2-b]pyridine 98% | K44806 | 100mg | $24 |
| Boiling point | 360.7±22.0 °C(Predicted) |
|---|---|
| Density | 2.082 |
| storage temp. | 2-8°C(protect from light) |
| pka | 13.16±0.40(Predicted) |
| Appearance | White to off-white Solid |
| InChI | InChI=1S/C7H5IN2/c8-5-4-10-6-2-1-3-9-7(5)6/h1-4,10H |
| InChIKey | ZLVQSDNBINQPHB-UHFFFAOYSA-N |
| SMILES | C12C(I)=CNC1=CC=CN=2 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H319-H335-H302+H312+H332-H315 |
| Precautionary statements | P301+P312-P302+P352-P305+P351+P338 |
| HS Code | 2933998090 |
3-iodo-1H-pyrrolo[3,2-b]pyridine price More Price(39)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | OR321324 | 3-Iodo-1H-pyrrolo[3,2-b]pyridine 97% | 1083181-26-3 | 250mg | $21 | 2026-06-04 | Buy |
| Activate Scientific | AS39384 | 3-Iodo-1H-pyrrolo[3,2-b]pyridine 98% | 1083181-26-3 | 1g | $50 | 2026-06-04 | Buy |
| Apolloscientific | OR321324 | 3-Iodo-1H-pyrrolo[3,2-b]pyridine 97% | 1083181-26-3 | 1g | $48 | 2026-06-04 | Buy |
| Activate Scientific | AS39384 | 3-Iodo-1H-pyrrolo[3,2-b]pyridine 98% | 1083181-26-3 | 5g | $139 | 2026-06-04 | Buy |
| Synthonix | K44806 | 3-Iodo-1H-pyrrolo[3,2-b]pyridine 98% | 1083181-26-3 | 100mg | $24 | 2026-05-06 | Buy |
3-iodo-1H-pyrrolo[3,2-b]pyridine Chemical Properties,Uses,Production
Uses
3-Iodo-1H-pyrrolo[3,2-B]pyridine is a pyridine derivative that can be used to prepare plasma kallikrein inhibitors.
Synthesis
272-49-1
![3-iodo-1H-pyrrolo[3,2-b]pyridine](/CAS/GIF/1083181-26-3.gif)
1083181-26-3
1H-pyrrolo[3,2-b]pyridine (1.94 g, 16.4 mmol) was used as starting material and dissolved in tetrahydrofuran (THF, 10 mL). Subsequently, N-iodosuccinimide (NIS, 4.06 g, 18.1 mmol) was added to this solution. The reaction mixture was stirred at room temperature overnight, during which precipitation was observed to be generated. Upon completion of the reaction, the precipitate was collected by filtration and washed sequentially with a small amount of THF and heptane. The resulting white solid was dried under vacuum to afford the target product 3-iodo-1H-pyrrolo[3,2-b]pyridine (4.1 g, quantitative yield). The structure of the product was confirmed by 1H NMR (DMSO-d6, 300 MHz) δ 8.40 (s, 1H), 7.90-7.70 (m, 2H), 7.15 (d, 1H) and LC-MS (retention time 0.41 min; m/z 245 [M+1]+).
References
[1] Patent: WO2011/78984, 2011, A1. Location in patent: Page/Page column 72
[2] Bioorganic and Medicinal Chemistry Letters, 2009, vol. 19, # 24, p. 6935 - 6938
[3] Patent: WO2018/11628, 2018, A1. Location in patent: Paragraph 00203
[4] Organic and Biomolecular Chemistry, 2011, vol. 9, # 14, p. 5129 - 5136
[5] Patent: US2015/94328, 2015, A1. Location in patent: Paragraph 0349; 0350-0352
3-iodo-1H-pyrrolo[3,2-b]pyridine Preparation Products And Raw materials
3-iodo-1H-pyrrolo[3,2-b]pyridine Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | sales@conier.com | China | 49979 | 58 | |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 17705817739 | info@dycnchem.com | China | 52704 | 58 |
| CR Corporation Limited | fred.wen@crcorporation.cn | China | 8645 | 58 | |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418684 +86-18949823763 | sales@tnjchem.com | China | 25356 | 58 |
| PT CHEM GROUP LIMITED | +86-85511178; +86-85511178 | peter68@ptchemgroup.com | China | 35425 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +86-571-86217390; +8618058761490 | info@gihichemicals.com | China | 49895 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52923 | 58 | |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131956 | 58 |
| Tianjin Ruide Famo Technology Co., Ltd | 13821803402 | RD_PHARM@163.com | China | 842 | 58 |
