3,4-Difluorobenzoic acid
- CAS No.
- 455-86-7
- Chemical Name:
- 3,4-Difluorobenzoic acid
- Synonyms
- Benzoic acid, 3,4-difluoro-;NSC 190686;TIMTEC-BB SBB006721;RARECHEM AL BO 0269;3,4-Difluorobenzoic;3,4-Difluorbenzoesure;3,4-Difluorbenzoicacid;3,4-Difuorobenzoic acid;3,4-DIFLUOROBENZOIC ACID;3, 4-2 fluoro benzoic acid
- CBNumber:
- CB7152724
- Molecular Formula:
- C7H4F2O2
- Molecular Weight:
- 158.1
- MDL Number:
- MFCD00011672
- MOL File:
- 455-86-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 3,4-Difluorobenzoic acid 98% | 264318 | 5g | $40.1 |
| 3,4-Difluorobenzoic Acid >98.0%(GC)(T) | D1908 | 5g | $99 |
| 3,4-Difluorobenzoic Acid >98.0%(GC)(T) | D1908 | 25g | $315 |
| 3,4-Difluorobenzoic acid Asreported | 273556 | 50g | $403 |
| 3,4-Difluorobenzoic acid Asreported | 273556 | 100g | $566 |
| More product size | |||
| Melting point | 120-122 °C(lit.) |
|---|---|
| Boiling point | 257.0±20.0 °C(Predicted) |
| Density | 1.3486 (estimate) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 3.80±0.10(Predicted) |
| color | White |
| Water Solubility | slightly soluble in cold water |
| BRN | 2085848 |
| InChI | InChI=1S/C7H4F2O2/c8-5-2-1-4(7(10)11)3-6(5)9/h1-3H,(H,10,11) |
| InChIKey | FPENCTDAQQQKNY-UHFFFAOYSA-N |
| SMILES | C(O)(=O)C1=CC=C(F)C(F)=C1 |
| CAS DataBase Reference | 455-86-7(CAS DataBase Reference) |
| FDA UNII | J5J3RFV8N6 |
| NIST Chemistry Reference | 3,4-Difluorobenzoic acid(455-86-7) |
| EPA Substance Registry System | Benzoic acid, 3,4-difluoro- (455-86-7) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319 | |||||||||
| Precautionary statements | P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313 | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22-36/37/38 | |||||||||
| Safety Statements | 26-37/39 | |||||||||
| WGK Germany | 3 | |||||||||
| TSCA | TSCA listed | |||||||||
| HS Code | 29163900 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 |
|||||||||
| NFPA 704 |
|
3,4-Difluorobenzoic acid price More Price(82)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 264318 | 3,4-Difluorobenzoic acid 98% | 455-86-7 | 5g | $40.1 | 2026-04-30 | Buy |
| TCI Chemical | D1908 | 3,4-Difluorobenzoic Acid >98.0%(GC)(T) | 455-86-7 | 5g | $99 | 2026-04-30 | Buy |
| TCI Chemical | D1908 | 3,4-Difluorobenzoic Acid >98.0%(GC)(T) | 455-86-7 | 25g | $315 | 2026-04-30 | Buy |
| Usbiological | 273556 | 3,4-Difluorobenzoic acid Asreported | 455-86-7 | 50g | $403 | 2026-06-03 | Buy |
| Usbiological | 273556 | 3,4-Difluorobenzoic acid Asreported | 455-86-7 | 100g | $566 | 2026-06-03 | Buy |
3,4-Difluorobenzoic acid Chemical Properties,Uses,Production
Chemical Properties
white to light yellow crystal powder
Uses
3,4-Difluoro-benzoic Acid is a useful synthetic intermediate. It is used to synthesize 2-arylbenzimidazole derivatives as melanin-concentrating hormone receptor 1 (MCH-R1) antagonists.
General Description
Ultra-trace determination of 3,4-difluorobenzoic acid in aqueous reservoir fluids has been reported using solid-phase extraction in combination with GC-MS.
Synthesis
2927-34-6
455-86-7
Example 5: Synthesis of 3,4-difluorobenzoic acid. In a 100 mL jacketed reactor, 200 mL of acetic acid, 0.05 g of manganese(II) acetate, 1.91 g of sulfuric acid, and 14.1 g of 3,4-difluorotoluene were added sequentially. The reaction mixture was cooled to 16°C, followed by the slow passage of 4.0 g of ozone over 60 min. Upon completion of the ozonolysis reaction, the reaction system was purged with nitrogen to remove residual ozone. HPLC or GC analysis of the reaction mixture showed that the residue of 3,4-difluorotoluene was <0.1%; the yield of 3,4-difluorobenzoic acid was 98%.
References
[1] Patent: US2003/216577, 2003, A1. Location in patent: Page/Page column 4
3,4-Difluorobenzoic acid Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Speranza Chemical Co., Ltd. | +86-86-075521030354 +86-18688942810 | sophieliu@speranzachem.com | China | 923 | 55 |
| Hebei Yanxi Chemical Co., Ltd. | +86-17531190177 | faithe@yan-xi.com | China | 5853 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-86-13131129325 | sales1@chuanghaibio.com | China | 5220 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +86-17732866630 | mina@chuanghaibio.com | China | 18126 | 58 |
| Hebei Zhuanglai Chemical Trading Co.,Ltd | 13343047651 | admin@zlchemi.com | China | 3692 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-2158073036 | info@dakenam.com | China | 14026 | 58 |
| Shanghai Time Chemicals CO., Ltd. | +86-021-57951555 +8618017249410 | jack.li@time-chemicals.com | China | 1803 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29812 | 58 |
View Lastest Price from 3,4-Difluorobenzoic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2026-07-31 | 3,4-Difluorobenzoic acid
455-86-7
|
$65.00 | 1KG | 99% | 300MT/year | Speranza Chemical Co., Ltd. | |
 |
2026-05-28 | 3, 4-Difluorobenzoic Acid
455-86-7
|
$9.00 | 1KG | 99% | 10 ton | Hebei Chuanghai Biotechnology Co,.LTD | |
 |
2026-02-02 | 3,4-Difluorobenzoic acid
455-86-7
|
98% | 200TONS | Shaanxi Dideu Medichem Co. Ltd |
-
- 3,4-Difluorobenzoic acid
455-86-7
- $65.00
- 99%
- Speranza Chemical Co., Ltd.
-
- 3, 4-Difluorobenzoic Acid
455-86-7
- $9.00
- 99%
- Hebei Chuanghai Biotechnology Co,.LTD
-
- 3,4-Difluorobenzoic acid
455-86-7
- $0.10
- 98%
- Shaanxi Dideu Medichem Co. Ltd
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