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ChemicalBook >> CAS DataBase List >>LEUKOTRIENE B4

LEUKOTRIENE B4

CAS No.
71160-24-2
Chemical Name:
LEUKOTRIENE B4
Synonyms
LTB4;LEUKOTRIENE B4;Leukotriene B?;LTB4 (Leukotriene B4);Leukotriene B4;VNYSSYRCGWBHLG-AMOLWHMGSA-N;Leukotriene B4 MaxSpecStandard;leukotriene B4 ethanol solution;Leukotriene B4 Lipid Maps MS Standard;Leukotriene B - CAS 71160-24-2 - Calbiochem
CBNumber:
CB7159905
Molecular Formula:
C20H32O4
Molecular Weight:
336.47
MDL Number:
MFCD00135630
MOL File:
71160-24-2.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 03:28:51
Product description Number Pack Size Price
Leukotriene B4 ~100?μg/mL in ethanol, ≥97% L0517 10μg $370
Leukotriene B4 ~100?μg/mL in ethanol, ≥97% L0517 25μg $585
Leukotriene B4 ~100?μg/mL in ethanol, ≥97% L0517 50μg $1010
Leukotriene B? - CAS 71160-24-2 - Calbiochem 434625 50μG $554
Leukotriene B4 ≥95% 20110 25μg $164

LEUKOTRIENE B4 Properties

Boiling point 536.4±50.0 °C(Predicted)
Density 1.040±0.06 g/cm3(Predicted)
Flash point 14 °C
storage temp. -20°C
solubility Soluble in ethanol (supplied pre-dissolved in anhydrous ethanol, 50μg/ml)
pka 4.66±0.10(Predicted)
form Clear oil
color Colorless to light yellow
InChIKey VNYSSYRCGWBHLG-AMOLWHMGSA-N
SMILES CCCCC\C=C/C[C@@H](O)\C=C\C=C\C=C/[C@@H](O)CCCC(O)=O
CAS DataBase Reference 71160-24-2(CAS DataBase Reference)
FDA UNII 1HGW4DR56D
UNSPSC Code 12352211
NACRES NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)  Flame (GHS02)Exclamation Mark (GHS07)
GHS02,GHS07
Signal word  Danger
Hazard statements  H225-H319
Precautionary statements  P210-P233-P240-P241-P242-P305+P351+P338
Hazard Codes  F
Risk Statements  11
Safety Statements  7-16
RIDADR  UN 1170 3/PG 2
WGK Germany  1
Storage Class 3 - Flammable liquids
Hazard Classifications Eye Irrit. 2
Flam. Liq. 2
NFPA 704
3
0 0

LEUKOTRIENE B4 price More Price(22)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich L0517 Leukotriene B4 ~100?μg/mL in ethanol, ≥97% 71160-24-2 10μg $370 2026-04-30 Buy
Sigma-Aldrich L0517 Leukotriene B4 ~100?μg/mL in ethanol, ≥97% 71160-24-2 25μg $585 2026-04-30 Buy
Sigma-Aldrich L0517 Leukotriene B4 ~100?μg/mL in ethanol, ≥97% 71160-24-2 50μg $1010 2026-04-30 Buy
Sigma-Aldrich 434625 Leukotriene B? - CAS 71160-24-2 - Calbiochem 71160-24-2 50μG $554 2026-04-30 Buy
Cayman Chemical 20110 Leukotriene B4 ≥95% 71160-24-2 25μg $164 2026-04-30 Buy
Product number Packaging Price Buy
L0517 10μg $370 Buy
L0517 25μg $585 Buy
L0517 50μg $1010 Buy
434625 50μG $554 Buy
20110 25μg $164 Buy

LEUKOTRIENE B4 Chemical Properties,Uses,Production

Description

Leukotriene B4 (LTB4) is a dihydroxy fatty acid derived from arachidonic acid through the 5-LO pathway. It promotes a number of leukocyte functions including aggregation, stimulation of ion fluxes, enhancement of lysosomal enzyme release, superoxide anion production, chemotaxis, and chemokinesis. In subnanomolar ranges (3.9 x 10−10 M), LTB4 causes chemotaxis and chemokinesis in human polymorphonuclear leukocytes. At higher concentrations, (1.0 x 10−7 M), LTB4 leads to neutrophil aggregation and degranulation as well as superoxide anion production.

LTB4 MaxSpec® standard is a quantitative grade standard of LTB4 that has been prepared specifically for mass spectrometry and related applications where quantitative reproducibility is required. The solution has been prepared gravimetrically and is supplied in a deactivated glass ampule sealed under argon. The concentration was verified by comparison to an independently prepared calibration standard. This LTB4 MaxSpec® standard is guaranteed to meet identity, purity, stability, and concentration specifications and is provided with a batch-specific certificate of analysis. Ongoing stability testing is performed to ensure the concentration remains accurate throughout the shelf life of the product. Note: The amount of solution added to the vial is in excess of the listed amount. Therefore, it is necessary to accurately measure volumes for preparation of calibration standards. Follow recommended storage and handling conditions to maintain product quality.

Uses

LTB4 (Leukotriene B4) is a potent chemokine with roles in inflammation, immunology, the nervous system, brain and skin.

Definition

ChEBI: A leukotriene composed of (6Z,8E,10E,14Z)-icosatetraenoic acid having (5S)- and (12R)-hydroxy substituents.

Biological Activity

Potent lipid inflammatory mediator derived from the 5-lipoxygenase pathway of arachidonic acid metabolism. Binds to BLT 1 and BLT 2 receptors and acts as a potent chemotactic agent and activator of leukocytes. Also displays antiviral activity towards DNA viruses and retroviruses.

Biochem/physiol Actions

Proinflammatory agent. Stimulates c-Fos and c-Jun proto-oncogene transcription in human monocytes. Stimulates chemotaxis, aggregation, and degranulation of polymorphonuclear leukocytes.

storage

Store at -20°C

References

[1] OLOF RDMARK. Leukotriene a: Stereochemistry and enzymatic conversion to leukotriene B[J]. Biochemical and biophysical research communications, 1980, 92 3: Pages 954-961. DOI: 10.1016/0006-291x(80)90795-0
[2] A. W. FORD-HUTCHINSON. Leukotriene B, a potent chemokinetic and aggregating substance released from polymorphonuclear leukocytes[J]. Nature, 1980, 286 5770: 264-265. DOI: 10.1038/286264a0
[3] J MCGEE  F F. Enzymatic hydration of leukotriene A4. Purification and characterization of a novel epoxide hydrolase from human erythrocytes.[J]. The Journal of Biological Chemistry, 1985, 260 23: 12832-12837.
[4] FORD-HUTCHINSON A W. Leukotriene B4 in inflammation.[J]. Critical Reviews in Immunology, 1990, 10 1: 1-12.
[5] R M MCMILLAN  S J F. Leukotriene B4 and inflammatory disease.[J]. Agents and Actions, 1988, 24 1-2: 114-119. DOI: 10.1007/bf01968088
[6] Neutrophil trapping and nexocytosis, mast cell-mediated processes for inflammatory signal relay[J]. Cell, 2024, 21 1. DOI: 10.1016/j.cell.2024.07.014
[7] TAKAKO ICHIKI. Modulation of leukotriene B4 receptor 1 signaling by receptor for advanced glycation end products (RAGE)[J]. FASEB Journal, 2016, 30 5: 1811-1822. DOI: 10.1096/fj.201500117
[8] BRUCE D. LEVY. Multi-pronged inhibition of airway hyper-responsiveness and inflammation by lipoxin A4[J]. Nature Medicine, 2002, 8 9: 1018-1023. DOI: 10.1038/nm748
[9] D FULTON. A method for the determination of 5,6-EET using the lactone as an intermediate in the formation of the diol.[J]. Journal of Lipid Research, 1998, 39 8: 1713-1721.

LEUKOTRIENE B4 Preparation Products And Raw materials

Raw materials

Preparation Products

LEUKOTRIENE B4 Suppliers

Global( 72)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc.
+1-781-999-5354; +17819995354 marketing@targetmol.com United States 32466 58
Career Henan Chemica Co
+86-0371-86658258 +8613203830695 laboratory@coreychem.com China 30225 58
TargetMol Chemicals Inc.
+1-781-999-5354; support@targetmol.com United States 39039 58
Aladdin Scientific
tp@aladdinsci.com United States 57505 58
Mainchem Co., Ltd. +86-0592-6210733 sale@mainchem.com China 32343 55
Shanghai Boyle Chemical Co., Ltd. 021-50182298 021-50180596 sales@boylechem.com China 2208 55
J & K SCIENTIFIC LTD. 18210857532; 18210857532 jkinfo@jkchemical.com China 96815 76
3B Pharmachem (Wuhan) International Co.,Ltd. 821-50328103-801 18930552037 3bsc@sina.com China 15838 69
BOC Sciences 1-631-485-4226; 16314854226 info@bocsci.com United States 9920 65
Shanghai Aladdin Bio-Chem Technology Co.,LTD 400-6206333 13167063860 anhua.mao@aladdin-e.com China 29974 65

View Lastest Price from LEUKOTRIENE B4 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Leukotriene B4 pictures 2026-05-11 Leukotriene B4
71160-24-2
10g TargetMol Chemicals Inc.
(5S,6Z,8E,10E,12R,14Z)-5,12-DIHYDROXY-6,8,10,14-EICOSATETRAENOIC ACID 5(S), 12(R)-DIHYDROXY-6-CIS-8-TRANS-10-TRANS-14-CIS-EICOSATETRAENOIC ACID [5S,12R]-DIHYDROXY-[6Z,8E,10E,14Z]-EICOSATETRAENOIC ACID 5,12-DIHYDROXY-[S-[R*,S-(E,Z,Z,E))]-6,8,10,14-EICOSATETRAENOIC ACID 5,12-DIHYDROXY-[S-[R*,S*-(E,Z,Z,E)]]-6,8,10,14-EICOSATETRAENOIC ACID LEUKOTRIENE B4 leukotriene B4 ethanol solution (5S,6Z,8E,10E,12R,14Z)-5,12-dihydroxyicosa-6,8,10,14-tetraenoic acid (5S,12R,6Z,8E,10E,14Z)-5,12-Dihydroxy-6,8,10,14-icosatetraenoic acid (5S,6Z,8E,10E,12R,14Z)-5,12-Dihydroxy-6,8,10,14-icosatetraenoic acid Leukotriene B4 Lipid Maps MS Standard LTB4 (Leukotriene B4) Leukotriene B? VNYSSYRCGWBHLG-AMOLWHMGSA-N Leukotriene B4 MaxSpecStandard Leukotriene B - CAS 71160-24-2 - Calbiochem 6,8,10,14-Eicosatetraenoic acid, 5,12-dihydroxy-, (5S,6Z,8E,10E,12R,14Z)- Leukotriene B4 LTB4 71160-24-2 Cancer Research BioChemical Tumor Growth Regulation Tumor Promotors Prostanoid receptor and related
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