4-TRIFLUOROMETHYL-BENZAMIDINE HCL
- CAS No.
- 38980-96-0
- Chemical Name:
- 4-TRIFLUOROMETHYL-BENZAMIDINE HCL
- Synonyms
- 4-TRIFLUOROMETHYL-BENZAMIDINE HCL;4-TrifluoroMethyl-benzanidibe HCL;4-Trifluoromethylbenzamidinehydrochloridel;4-TRIFLUOROMETHYL-BENZAMIDINE HYDROCHLORIDE;4-TRIFLUOROMETHYL-BENZAMIDINE HCL ISO 9001：2015 REACH;4-(Trifluoromethyl)benzenecarboximidamide hydrochloride;4-(Trifluoromethyl)benzene-1-carboximidamide hydrochloride;4-(TrifluoroMethyl)benzenecarboxiMidaMide hydrochloride (1:1)
- CBNumber:
- CB7199927
- Molecular Formula:
- C8H8ClF3N2
- Molecular Weight:
- 224.61
- MDL Number:
- MFCD04114431
- MOL File:
- 38980-96-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 4-(Trifluoromethyl)benzamidine | CVT00069 | 1g | $586 |
| 4-(Trifluoromethyl)benzamidine Hydrochloride >98.0%(HPLC) | T3115 | 200mg | $114 |
| 4-(Trifluoromethyl)benzamidine Hydrochloride >98.0%(HPLC) | T3115 | 1g | $329 |
| 4-(Trifluoromethyl)benzamidine hydrochloride 98% | PC446016 | 5g | $21 |
| 4-(Trifluoromethyl)benzamidine hydrochloride 98% | PC446016 | 25g | $73 |
| Melting point | 158-161℃ |
|---|---|
| storage temp. | Inert atmosphere,Room Temperature |
| form | powder to crystal |
| color | White to Almost white |
| InChI | 1S/C8H7F3N2/c9-8(10,11)6-3-1-5(2-4-6)7(12)13/h1-4H,(H3,12,13) |
| InChIKey | XFLGYXVBXUAGQV-UHFFFAOYSA-N |
| SMILES | NC(C1=CC=C(C=C1)C(F)(F)F)=N |
| UNSPSC Code | 12352200 |
| NACRES | NA.21 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H317-H319 | |||||||||
| Precautionary statements | P280-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38-43 | |||||||||
| Safety Statements | 26-37/39-36/37 | |||||||||
| WGK Germany | WGK 3 | |||||||||
| HS Code | 2925290090 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Sens. 1 |
|||||||||
| NFPA 704 |
|
4-TRIFLUOROMETHYL-BENZAMIDINE HCL price More Price(60)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | CVT00069 | 4-(Trifluoromethyl)benzamidine | 38980-96-0 | 1g | $586 | 2026-04-30 | Buy |
| TCI Chemical | T3115 | 4-(Trifluoromethyl)benzamidine Hydrochloride >98.0%(HPLC) | 38980-96-0 | 200mg | $114 | 2026-04-30 | Buy |
| TCI Chemical | T3115 | 4-(Trifluoromethyl)benzamidine Hydrochloride >98.0%(HPLC) | 38980-96-0 | 1g | $329 | 2026-04-30 | Buy |
| Apolloscientific | PC446016 | 4-(Trifluoromethyl)benzamidine hydrochloride 98% | 38980-96-0 | 5g | $21 | 2026-06-04 | Buy |
| Apolloscientific | PC446016 | 4-(Trifluoromethyl)benzamidine hydrochloride 98% | 38980-96-0 | 25g | $73 | 2026-06-04 | Buy |
4-TRIFLUOROMETHYL-BENZAMIDINE HCL Chemical Properties,Uses,Production
Uses
4-Trifluoromethylbenzamide hydrochloride is used as a pharmaceutical synthesis intermediate.
Synthesis
455-18-5
38980-96-0
4-(Trifluoromethyl)benzonitrile (15g, Avocado 14514) was used as raw material, which was dissolved in anhydrous methanol (90 ml) and sodium methanolate (0.50 g) was added. The reaction mixture was stirred at room temperature for 4 days. Subsequently, ammonium chloride (4.7 g) was added to the reaction system and stirring was continued for 24 hours. Upon completion of the reaction, the solvent was removed by rotary evaporator and the white solid residue obtained was ground with ether, filtered and dried to afford the target product 4-(trifluoromethyl)benzamidine hydrochloride as a white solid (14.2 g, 72% yield). Mass spectrometry analysis showed a molecular ion peak of 188 [M]+.
References
[1] Patent: US2003/69276, 2003, A1
[2] Journal of the American Chemical Society, 1985, vol. 107, # 9, p. 2743 - 2748
[3] Journal of Medicinal Chemistry, 1990, vol. 33, # 4, p. 1230 - 1241
[4] Patent: US6121202, 2000, A
[5] Patent: US2012/165343, 2012, A1. Location in patent: Page/Page column 55
4-TRIFLUOROMETHYL-BENZAMIDINE HCL Preparation Products And Raw materials
Raw materials
Preparation Products
4-TRIFLUOROMETHYL-BENZAMIDINE HCL Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10403 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | sales@conier.com | China | 49979 | 58 | |
| SIMAGCHEM CORP | +86-5922680277 +86-13806087780 | sale@simagchem.com | China | 17346 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +86-13203830695 | laboratory@coreychem.com | China | 30224 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +86-189 4982 3763 | sales@tnjchem.com | China | 34563 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8618071025641 | eric@witopchemical.com | China | 23541 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1059@dideu.com | China | 29093 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 17705817739 | info@dycnchem.com | China | 52704 | 58 |
| Nextpeptide Inc | +86-0571-81612335 +8613336028439 | sales@nextpeptide.com | China | 19908 | 58 |
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