6-nitrocoumarin
- CAS No.
- 2725-81-7
- Chemical Name:
- 6-nitrocoumarin
- Synonyms
- 6-NITROCOUMARIN;6-Nitrocoumarin>6-Nitrocoumarin, 98+%;6-nitro-2-benzopyrone;6-NITRO-2H-CHROMEN-2-ONE;6-Nitro-2H-1-benzopyran-2-one;2H-1-Benzopyran-2-one, 6-nitro-;N-[4-[(2-methyl-4,5-dihydro-3H-imidazo[4,5-d][1]benzazepin-6-yl)-oxomethyl]phenyl]-2-phenylbenzamide hydrochloride
- CBNumber:
- CB7202339
- Molecular Formula:
- C9H5NO4
- Molecular Weight:
- 191.14
- MDL Number:
- MFCD00016973
- MOL File:
- 2725-81-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 6-Nitrocoumarin >98.0%(GC) | N0923 | 5g | $60 |
| 6-Nitrocoumarin >98.0%(GC) | N0923 | 25g | $204 |
| 6-Nitrocoumarin Asreported | 285848 | 10g | $232 |
| 6-Nitrocoumarin | 234805 | 1g | $163 |
| 6-Nitrocoumarin Asreported | 285848 | 25g | $343 |
| Melting point | 186 °C |
|---|---|
| Boiling point | 326.87°C (rough estimate) |
| Density | 1.4625 (rough estimate) |
| refractive index | 1.4500 (estimate) |
| storage temp. | Inert atmosphere,Room Temperature |
| form | powder to crystal |
| color | White to Orange to Green |
| BRN | 166079 |
| CAS DataBase Reference | 2725-81-7(CAS DataBase Reference) |
| FDA UNII | M32MSC62RG |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H319 | |||||||||
| Precautionary statements | P305+P351+P338 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 40-22 | |||||||||
| Safety Statements | 22-24/25-36-37/39-26 | |||||||||
| HS Code | 2932.20.4500 | |||||||||
| NFPA 704 |
|
6-nitrocoumarin price More Price(55)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | N0923 | 6-Nitrocoumarin >98.0%(GC) | 2725-81-7 | 5g | $60 | 2026-04-30 | Buy |
| TCI Chemical | N0923 | 6-Nitrocoumarin >98.0%(GC) | 2725-81-7 | 25g | $204 | 2026-04-30 | Buy |
| Usbiological | 285848 | 6-Nitrocoumarin Asreported | 2725-81-7 | 10g | $232 | 2026-06-03 | Buy |
| Usbiological | 234805 | 6-Nitrocoumarin | 2725-81-7 | 1g | $163 | 2026-06-03 | Buy |
| Usbiological | 285848 | 6-Nitrocoumarin Asreported | 2725-81-7 | 25g | $343 | 2026-06-03 | Buy |
6-nitrocoumarin Chemical Properties,Uses,Production
Synthesis
91-64-5
2725-81-7
The method was carried out with reference to the literature (Roy et al., 2011). In a 250 mL three-necked flask equipped with a condenser tube, thermometer and dropping funnel, coumarin (10 g, 68.5 mmol) and 50 mL of concentrated sulfuric acid (0.935 mol) were added. After cooling the reaction system to -10 °C, a mixture consisting of concentrated sulfuric acid (15 mL, 0.28 mol) and fuming nitric acid (5 mL, 0.12 mol) was added slowly and dropwise over a period of 1 hour, during which the reaction temperature was kept below -5 °C. Upon completion of the reaction, the mixture was decanted into ice water, the precipitate was collected by filtration and recrystallized from acetic acid. A white solid 11.26 g of 6-nitro-2H-benzopyran-2-one was obtained in 86% yield with a melting point of 191-192.5 °C (literature value 188-190 °C). The structure of the product was confirmed by 1H NMR and 13C NMR: 1H NMR (400.13 MHz, CDCl3) δ 6.60 (d, J = 9.5 Hz, 1H), 7.48 (d, J = 9.0 Hz, 1H), 7.83 (d, J = 9.5 Hz, 1H), 8.42 (dd, J = 9.0 Hz, 2.5 Hz, 1H). 8.46 (d, J = 2.5 Hz, 1H); 13C NMR (100.62 MHz, CDCl3) δ 118.1, 118.8, 118.8, 123.7, 126.6, 142.2, 144.0, 157.5, 158.8.
References
[1] European Journal of Medicinal Chemistry, 2011, vol. 46, # 12, p. 5894 - 5901
[2] Synthetic Communications, 2001, vol. 31, # 2, p. 301 - 309
[3] Molecular Pharmacology, 1995, vol. 48, # 6, p. 1063 - 1067
[4] Polyhedron, 2011, vol. 30, # 6, p. 913 - 922
[5] Journal of Inorganic Biochemistry, 2011, vol. 105, # 4, p. 577 - 588
6-nitrocoumarin Preparation Products And Raw materials
6-nitrocoumarin Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | sales@conier.com | China | 49979 | 58 | |
| Career Henan Chemica Co | +86-0371-86658258 +86-13203830695 | laboratory@coreychem.com | China | 30224 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +86-189 4982 3763 | sales@tnjchem.com | China | 34563 | 58 |
| Blocksynth Pharmaceutical Technology Co.,Ltd | 0086-19817745290; 19817745290 | bd@blocksynth.com | China | 5973 | 58 |
| sgtlifesciences pvt ltd | +91-8790379245 | dj@sgtlifesciences.com | China | 12373 | 58 |
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| XIAMEN AMITY INDUSTRY AND TRADE CO., LTD. | +8618950047208 | ellena@amitychem.com | China | 43414 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131956 | 58 |
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