Fluoromethyl phenyl sulfone
- CAS No.
- 20808-12-2
- Chemical Name:
- Fluoromethyl phenyl sulfone
- Synonyms
- FLUOROMETHYLSULFONYLBENZENE;FLUOROMETHYL PHENYL SULFONE;FluoromethylPhenylSulfone>Phenyl Fluoromethyl Sulfone;Fluoromethanesulfonyl-benzene;Benzene, [(fluoromethyl)sulfonyl]-;fluoromethylsulfonylbenzene - [F70870]
- CBNumber:
- CB7230066
- Molecular Formula:
- C7H7FO2S
- Molecular Weight:
- 174.19
- MDL Number:
- MFCD00191650
- MOL File:
- 20808-12-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Fluoromethyl Phenyl Sulfone >98.0%(GC) | F0341 | 1g | $206 |
| Fluoromethyl Phenyl Sulfone >98.0%(GC) | F0341 | 5g | $694 |
| Fluoromethyl Phenyl Sulfone Asreported | 278225 | 250mg | $306 |
| Fluoromethyl Phenyl Sulfone Asreported | 278225 | 500mg | $419 |
| Fluoromethyl Phenyl Sulfone Asreported | 278225 | 1g | $565 |
| Melting point | 53 °C |
|---|---|
| Boiling point | 151 °C(Press: 0.3 Torr) |
| Density | 1.274±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | soluble in Methanol |
| form | powder to crystal |
| color | White to Almost white |
| InChI | InChI=1S/C7H7FO2S/c8-6-11(9,10)7-4-2-1-3-5-7/h1-5H,6H2 |
| InChIKey | DENHPZASLKBBHA-UHFFFAOYSA-N |
| SMILES | C1(S(CF)(=O)=O)=CC=CC=C1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319 |
| Precautionary statements | P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313 |
| Safety Statements | 24/25 |
| HS Code | 29309090 |
Fluoromethyl phenyl sulfone price More Price(50)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | F0341 | Fluoromethyl Phenyl Sulfone >98.0%(GC) | 20808-12-2 | 1g | $206 | 2026-04-30 | Buy |
| TCI Chemical | F0341 | Fluoromethyl Phenyl Sulfone >98.0%(GC) | 20808-12-2 | 5g | $694 | 2026-04-30 | Buy |
| Usbiological | 278225 | Fluoromethyl Phenyl Sulfone Asreported | 20808-12-2 | 250mg | $306 | 2026-06-03 | Buy |
| Usbiological | 278225 | Fluoromethyl Phenyl Sulfone Asreported | 20808-12-2 | 500mg | $419 | 2026-06-03 | Buy |
| Usbiological | 278225 | Fluoromethyl Phenyl Sulfone Asreported | 20808-12-2 | 1g | $565 | 2026-06-03 | Buy |
Fluoromethyl phenyl sulfone Chemical Properties,Uses,Production
Description
Fluoromethyl phenyl sulfone is a useful nucleophilic monofluoromethylation reagent for the synthesis of fluoromethyl alcohols and amines. In the nucleophilic reaction step, strong bases such as LiHMDS and n-BuLi are used to generate the nucleophilic (phenylsulfonyl)fluoromethyl anion. In the desulfonylation step, sodium/mercury amalgam and magnesium are the commonly used reductive reagents. Besides, the addition reaction between fluoromethyl phenyl sulfone and carbonyls can be used to prepare monofluoroaklenes via acylation–elimination.
Uses
Fluoromethyl phenyl sulfone can be used to prepare monofluoroaklenes and chiral α-Monofluoromethyl Amines. Highly stereoselective nucleophilic monofluoromethylation of (R)-(tert-butanesulfinyl)imines with fluoromethyl phenyl sulfone was achieved to afford α-monofluoromethylamines with a nonchelation-controlled stereoselectivity mode. By using the same chemistry, (R)-(tert-butanesulfinyl)imines bearing a terminal tosylate (OTs) group can be converted to α-monofluoromethylated cyclic secondary amines with high stereoselectivity.
Reactions
(1) Monofluoromethylation of aldehydes and ketones.
(2) Monofluoromethylation of aldimines and ketimines.
(3) Monofluoromethylenation of aldehydes and ketones.
(4) (Phenylsulfonyl)fluoromethylation of esters.
References
[1] YA LI. Stereoselective Nucleophilic Monofluoromethylation of N-(tert-Butanesulfinyl)imines with Fluoromethyl Phenyl Sulfone[J]. Organic Letters, 2006. DOI:10.1021/ol060322t.
[2] M. INBASEKARAN. ChemInform Abstract: A NOVEL AND EFFICIENT SYNTHESIS OF FLUOROMETHYL PHENYL SULFONE AND ITS USE AS A FLUOROMETHYL WITTIG EQUIVALENT[J]. ChemInform, 1985. DOI:10.1002/chin.198536160.
[3] GOUVERNEUR V, LOZANO ó. Preparation of Chiral α-Monofluoromethyl Amines Using Fluoromethyl Phenyl Sulfone[C]. 1900. DOI:10.1055/sos-SD-203-00578.
Fluoromethyl phenyl sulfone Preparation Products And Raw materials
Fluoromethyl phenyl sulfone Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| JIAXING REGEN CHEMICAL CO.,LTD | +8613385739570 | regen_chemical1@163.com | China | 226 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23541 | 58 |
| Finetech Industry Limited | +86-27-8746-5837 +8619945049750 | info@finetechnology-ind.com | China | 9539 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52704 | 58 |
| Labnetwork lnc. | +86-27-50766799 +8618062016861 | contact@labnetwork.com | China | 19987 | 58 |
| PT CHEM GROUP LIMITED | +86-85511178; | peter68@ptchemgroup.com | China | 35425 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +86-571-86217390; +8618058761490 | info@gihichemicals.com | China | 49895 | 58 |
View Lastest Price from Fluoromethyl phenyl sulfone manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2025-04-04 | Fluoromethyl phenyl sulfone
20808-12-2
|
1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd.
|
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- Fluoromethyl phenyl sulfone
20808-12-2
- 98%
- Henan Aochuang Chemical Co.,Ltd.
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