2-Chloro-6-pyrazinecarboxylic acid methyl ester
- CAS No.
- 23611-75-8
- Chemical Name:
- 2-Chloro-6-pyrazinecarboxylic acid methyl ester
- Synonyms
- Methyl 6-chloropyrazine-2-carboxylate;ethyl 6-chloropyrazine-2-carboxylate;m90108;6-Chloro-pyrazine-2-c;6-Chloro-pyrazine-2-carbo...;6-Chloro-pyrazine -2-carboxylate;Methyl 2-chloropyrazine-6-carboxylate;METHYL 6-CHLORO-2-PYRAZINECARBOXYLATE;Methyl6-chloropyrazine-2-carboxylate,95%;Methyl 6-chloropyrazine-2-carboxylate 97+%
- CBNumber:
- CB72322112
- Molecular Formula:
- C6H5ClN2O2
- Molecular Weight:
- 172.57
- MDL Number:
- MFCD10686598
- MOL File:
- 23611-75-8.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| METHYL 6-CHLOROPYRAZINE-2-CARBOXYLATE 97% | 52310 | 1G | $19 |
| METHYL 6-CHLOROPYRAZINE-2-CARBOXYLATE 97% | 52310 | 5G | $68 |
| METHYL 6-CHLOROPYRAZINE-2-CARBOXYLATE 97% | 52310 | 10G | $115 |
| Methyl 6-chloropyrazine-2-carboxylate >97% | OR301016 | 1g | $21 |
| Methyl 6-chloropyrazine-2-carboxylate >97% | OR301016 | 5g | $29 |
| More product size | |||
| Melting point | 40-41 °C |
|---|---|
| Boiling point | 60-70 °C(Press: 30 Torr) |
| Density | 1.372±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| pka | -2.28±0.10(Predicted) |
| form | Solid |
| Appearance | Light yellow to brown Solid |
| InChI | InChI=1S/C6H5ClN2O2/c1-11-6(10)4-2-8-3-5(7)9-4/h2-3H,1H3 |
| InChIKey | MVVYUJFEXRODQA-UHFFFAOYSA-N |
| SMILES | C1(C(OC)=O)=NC(Cl)=CN=C1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| HS Code | 2933119000 | |||||||||
| NFPA 704 |
|
2-Chloro-6-pyrazinecarboxylic acid methyl ester price More Price(64)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| AstaTech | 52310 | METHYL 6-CHLOROPYRAZINE-2-CARBOXYLATE 97% | 23611-75-8 | 1G | $19 | 2026-04-30 | Buy |
| AstaTech | 52310 | METHYL 6-CHLOROPYRAZINE-2-CARBOXYLATE 97% | 23611-75-8 | 5G | $68 | 2026-04-30 | Buy |
| AstaTech | 52310 | METHYL 6-CHLOROPYRAZINE-2-CARBOXYLATE 97% | 23611-75-8 | 10G | $115 | 2026-04-30 | Buy |
| Apolloscientific | OR301016 | Methyl 6-chloropyrazine-2-carboxylate >97% | 23611-75-8 | 1g | $21 | 2026-06-04 | Buy |
| Apolloscientific | OR301016 | Methyl 6-chloropyrazine-2-carboxylate >97% | 23611-75-8 | 5g | $29 | 2026-06-04 | Buy |
2-Chloro-6-pyrazinecarboxylic acid methyl ester Chemical Properties,Uses,Production
Synthesis
770-00-3
23611-75-8
The product of Example 1D (7.18 g, 45.9 mmol) was taken as raw material and dissolved in dichlorosulfoxide (SOCl2, 50 mL, 687 mmol). The reaction mixture was heated to reflux and kept for 8 hours and then cooled to room temperature. Excess SOCl2 was evaporated under reduced pressure followed by slow addition of water (50 mL) at 0 °C to quench the reaction. The reaction mixture was neutralized with 1 M aqueous potassium carbonate (K2CO3, aq), followed by multiple extractions with dichloromethane (CH2Cl2, 5 × 100 mL). All organic phase extracts were combined, washed with saturated saline (100 mL), dried over anhydrous sodium sulfate (Na2SO4), filtered and concentrated under reduced pressure. The resulting residue was purified by silica gel column chromatography (eluent: 5% ethyl acetate in dichloromethane solution, Rf=0.35) to afford methyl 6-chloropyrazine-2-carboxylate as a thick oil, which gradually solidified after standing (7.16 g, 67% yield). The product was characterized by 1H NMR (DMSO-d6, 300 MHz): δ 3.94 (s, 3H), 9.07 (s, 1H), 9.19 (s, 1H). Mass spectrum (DCI/NH3) showed m/z 190 (M+NH4)+.
References
[1] Patent: US2009/281118, 2009, A1. Location in patent: Page/Page column 10-11
[2] Bioorganic and Medicinal Chemistry, 2010, vol. 18, # 22, p. 7816 - 7825
[3] Journal of Medicinal Chemistry, 2011, vol. 54, # 21, p. 7678 - 7692
2-Chloro-6-pyrazinecarboxylic acid methyl ester Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | +86-13017695106 +86-13676922317 | jiuyitime@fdachem.com | China | 16512 | 58 |
| Springchem New Material Technology Co.,Limited | +86-021-62885108 +8613917661608 | info@spring-chem.com | China | 2068 | 57 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29815 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Shanghai Worldyang Chemical Co.,Ltd. | +86-021-56795779 +8613651600618 | sales@worldyachem.com | China | 967 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
View Lastest Price from 2-Chloro-6-pyrazinecarboxylic acid methyl ester manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-04-17 | Methyl 6-chloropyrazine-2-carboxylate
23611-75-8
|
$1.60-6.60 | 1kg | 99% | 100kg | ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | |
 |
2025-11-18 | 2-Chloro-6-pyrazinecarboxylic acid methyl ester
23611-75-8
|
$1.10 | 1g | 99.00% | 100 Tons | Dideu Industries Group Limited | |
 |
2020-04-29 | 2-Chloro-6-pyrazinecarboxylic acid methyl ester
23611-75-8
|
1KG | 99.0%+ | 800 tons | Shaanxi Dideu Medichem Co. Ltd |
-
- Methyl 6-chloropyrazine-2-carboxylate
23611-75-8
- $1.60-6.60
- 99%
- ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
-
- 2-Chloro-6-pyrazinecarboxylic acid methyl ester
23611-75-8
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- 2-Chloro-6-pyrazinecarboxylic acid methyl ester
23611-75-8
- 99.0%+
- Shaanxi Dideu Medichem Co. Ltd
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