Methyllithium
- CAS No.
- 917-54-4
- Chemical Name:
- Methyllithium
- Synonyms
- MELI;LITHIUM METHANIDE;Methyllithium lithium bromide complex solution;Methyllithium solution;Lowhalide;1-2MinEther;methyl-lithiu;METHYLLITHIUM;Methy-Lithium;LITHIUM METHYL
- CBNumber:
- CB7234211
- Molecular Formula:
- CH3Li
Lewis structure
- Molecular Weight:
- 21.98
- MDL Number:
- MFCD00008253
- MOL File:
- 917-54-4.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| Methyllithium solution 1.6M in diethyl ether | 197343 | 1l | $340 |
| Methyllithium lithium bromide complex solution 1.5?M in diethyl ether | 186201 | 100mL | $107 |
| Methyllithium lithium bromide complex solution 1.5?M in diethyl ether | 186201 | 4x25ml | $137 |
| Methyllithium lithium bromide complex solution 1.5?M in diethyl ether | 186201 | 800mL | $633 |
| Methyllithium lithium bromide complex solution 1.5?M in diethyl ether | 186201 | 1L | $681 |
| More product size | |||
| Melting point | 70-71℃ |
|---|---|
| Boiling point | 88℃ |
| Density | 0.85 g/mL at 20 °C |
| vapor density | 3 (vs air) |
| Flash point | 5 °F |
| storage temp. | 2-8°C |
| form | Solution |
| color | Colorless to yellow |
| Specific Gravity | 0.83 |
| explosive limit | 1.7-36% (v/v) Information refers to the main component.) |
| Water Solubility | Reacts with water. |
| Sensitive | Air & Moisture Sensitive |
| Hydrolytic Sensitivity | 9: reacts extremely rapidly with atmospheric moisture - may be pyrophoric - glove box or sealed system required |
| BRN | 3587162 |
| InChI | 1S/CH3.Li/h1H3; |
| InChIKey | DVSDBMFJEQPWNO-UHFFFAOYSA-N |
| SMILES | [Li]C |
| CAS DataBase Reference | 917-54-4(CAS DataBase Reference) |
| EPA Substance Registry System | Lithium, methyl- (917-54-4) |
| UNSPSC Code | 12352103 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS05 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H250-H260-H314 | |||||||||
| Precautionary statements | P210-P222-P231+P232-P233-P280-P223-P260-P264-P302+P334-P370+P378-P301+P330+P331-P303+P361+P353-P363-P304+P340-P310-P305+P351+P338-P402+P404-P405-P501 | |||||||||
| PPE | Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter | |||||||||
| Hazard Codes | F+,C,N,F,Xn,Xi | |||||||||
| Risk Statements | 12-15-17-22-34-66-67-65-51/53-11-36/37/38-36/38-19-40-36/37-37-14/15 | |||||||||
| Safety Statements | 16-26-36/37/39-45-43-30-60-62-61-36/37 | |||||||||
| RIDADR | UN 3399 4.3/PG 1 | |||||||||
| WGK Germany | 2 | |||||||||
| F | 10 | |||||||||
| Autoignition Temperature | 180°C (Information refers to the main component.) | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | 4.3 | |||||||||
| PackingGroup | I | |||||||||
| HS Code | 29319090 | |||||||||
| Storage Class | 4.2 - Pyrophoric and self-heating hazardous materials | |||||||||
| Hazard Classifications | Eye Dam. 1 Flam. Liq. 2 Pyr. Liq. 1 Skin Corr. 1B Water-react 1 |
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| REACH Registrations | Active | |||||||||
| NFPA 704 |
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Methyllithium price More Price(22)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 197343 | Methyllithium solution 1.6M in diethyl ether | 917-54-4 | 1l | $340 | 2026-04-30 | Buy |
| Sigma-Aldrich | 186201 | Methyllithium lithium bromide complex solution 1.5?M in diethyl ether | 917-54-4 | 100mL | $107 | 2026-04-30 | Buy |
| Sigma-Aldrich | 186201 | Methyllithium lithium bromide complex solution 1.5?M in diethyl ether | 917-54-4 | 4x25ml | $137 | 2026-04-30 | Buy |
| Sigma-Aldrich | 186201 | Methyllithium lithium bromide complex solution 1.5?M in diethyl ether | 917-54-4 | 800mL | $633 | 2026-04-30 | Buy |
| Sigma-Aldrich | 186201 | Methyllithium lithium bromide complex solution 1.5?M in diethyl ether | 917-54-4 | 1L | $681 | 2026-04-30 | Buy |
Methyllithium Chemical Properties,Uses,Production
Chemical Properties
Methyllithium is a colorless to yellowish solution, It is insoluble in hydrocarbon solvents although propyllithium and the higher homologues are miscible in hydrocarbons. Methyllithium is soluble in diethyl ether to about 6% by weight at room temperature (with or without lithium bromide) and is a little less soluble in tetrahydrofuran. Cooling of these solutions produces clear, colorless crystals of methyllithium etherate. Methyllithium is stable to about 200°C, at which temperature it disproportionates to dilithiomethane and methane.
Uses
There are no significant industrial uses of methyllithium, but it is widely used in the laboratory in Grignard type reactions.
Methyllithium is an organolithium reagent mainly used for deprotonation and as a source of methyl anion. It is a strong base and a strong nucleophile.
Uses
Methyllithium lithium bromide complex solution (MeLi.LiBr) can be used as a methylating agent for the α-methylation of alkoxyaryl ketones.
Definition
ChEBI: Methyllithium is an alkyllithium compound and a one-carbon compound.
Preparation
Methyllithium is produced industrially by the reaction of methyl chloride or methyl bromide with lithium metal dispersion in diethyl ether. The reaction with methyl chloride yields a solution of methyllithium and a precipitate of lithium chloride which may be readily separated. When methyl bromide is used, the lithium bromide byproduct remains in solution and complexes with the methyllithium. This reduces the reactivity of the methyllithium and, in certain cases, affects its usefulness. On the other hand, the less reactive complex is more stable in diethyl ether. Methyllithium produced from methyl chloride contains only about 0.3 % lithium chloride in a 5 % solution in diethyl ether. It is more reactive than the lithium bromide complex, but decomposes at the rate of 1 % of the contained methyllithium per year (that is 5.00 % solution goes to 4.95 %) at room temperature. The decomposition by ether cleavage results in methane and ethylene formation which increases the pressure in the container on long storage. Methyllithium can be prepared easily in tetrahydrofuran but it has a half-life of only about 2 days at room temperature due to solvent cleavage.
Application
Methyllithium solution (1.6M in diethyl ether) has been used for the asymmetric allylic alkylation (AAA) of allylic electrophiles in the presence of a chiral copper catalyst. This protocol leads to the C-C bond formation of tertiary and quaternary stereogenic centers with high enantioselectivity. It can also be used for the synthesis of ()-salsolidine by reacting with 6,7-dimethoxy-3,4-dihydroisoquinoline in the presence of ()-sparteine as a chiral ligand.
Hazard
Flammable, dangerous fire and explosionrisk, self-ignites in air.
Methyllithium Preparation Products And Raw materials
Raw materials
Preparation Products
1of4
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Chuanghai Biotechnology Co., Ltd | +86-15350571055 | Sibel@chuanghaibio.com | China | 8738 | 58 |
| Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1803 | 55 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21585 | 55 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29812 | 58 |
| Shandong chuangyingchemical Co., Ltd. | 18853181302 | sale@chuangyingchem.com | CHINA | 5906 | 58 |
| CONIER CHEM AND PHARMA LIMITED | sales@conier.com | China | 49979 | 58 | |
| Richest Group Ltd | 18017061086 | oled@richest-group.com | CHINA | 5600 | 58 |
| Antai Fine Chemical Technology Co.,Limited | 18503026267 | info@antaichem.com | CHINA | 9636 | 58 |
| SIMAGCHEM CORP | +86-5922680277 +86-13806087780 | sale@simagchem.com | China | 17346 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +86-189 4982 3763 | sales@tnjchem.com | China | 34563 | 58 |
View Lastest Price from Methyllithium manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-03-20 | Methyllithium
917-54-4
|
$9.90 | 1KG | 99% | 5tons | Hebei Chuanghai Biotechnology Co., Ltd | |
 |
2023-05-27 | Methyllithium
917-54-4
|
$100.00 | 25kg | 99% | 500t/month | Henan Bao Enluo International TradeCo.，LTD | |
 |
2019-07-06 | METHYLLITHIUM
917-54-4
|
$1.00 | 1KG | 98% | 1 | Career Henan Chemical Co |
-
- Methyllithium
917-54-4
- $9.90
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- Methyllithium
917-54-4
- $100.00
- 99%
- Henan Bao Enluo International TradeCo.，LTD
-
- METHYLLITHIUM
917-54-4
- $1.00
- 98%
- Career Henan Chemical Co
