3,4,5-Trimethoxycinnamic acid
- CAS No.
- 90-50-6
- Chemical Name:
- 3,4,5-Trimethoxycinnamic acid
- Synonyms
- 3-(3,4,5-TRIMETHOXYPHENYL)ACRYLIC ACID;AKOS BBS-00000775;RARECHEM BK HC T328;o-methylsinapicacid;OTAVA-BB BB7119152925;TRIMETHOXYCINNAMICACID;3,4,5-Trimethoxycinnamic;3,4,5-Trimethoxyzimtsure;5-TriMethoxycinnaMic acid;3,4,5-Trimethoxycinmic acid
- CBNumber:
- CB7236422
- Molecular Formula:
- C12H14O5
- Molecular Weight:
- 238.24
- MDL Number:
- MFCD00004388
- MOL File:
- 90-50-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 3,4,5-Trimethoxycinnamic acid 97% | T70408 | 25g | $58.9 |
| 3,4,5-Trimethoxycinnamic acid | FT71389 | 1kg | $259.6 |
| 3,4,5-Trimethoxycinnamic acid | FT71389 | 2kg | $415.36 |
| 3,4,5-Trimethoxycinnamic acid ≥98% | CS-W012839 | 100g | $40 |
| 3,4,5-Trimethoxycinnamic acid ≥98% | CS-W012839 | 500g | $142 |
| More product size | |||
| Melting point | 125-127 °C (lit.) |
|---|---|
| Boiling point | 300.83°C (rough estimate) |
| Density | 1.1416 (rough estimate) |
| vapor pressure | 0-0Pa at 20-25℃ |
| refractive index | 1.4571 (estimate) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. |
| form | Solid:crystalline |
| pka | 4.48±0.10(Predicted) |
| color | White |
| BRN | 1537834 |
| Major Application | food and beverages |
| InChI | InChI=1S/C12H14O5/c1-15-9-6-8(4-5-11(13)14)7-10(16-2)12(9)17-3/h4-7H,1-3H3,(H,13,14) |
| InChIKey | YTFVRYKNXDADBI-UHFFFAOYSA-N |
| SMILES | C(O)(=O)C=CC1=CC(OC)=C(OC)C(OC)=C1 |
| LogP | 0.3-1.1 at 35℃ and pH2-7 |
| CAS DataBase Reference | 90-50-6(CAS DataBase Reference) |
| FDA UNII | C9096D920O |
| EPA Substance Registry System | 2-Propenoic acid, 3-(3,4,5-trimethoxyphenyl)- (90-50-6) |
| UNSPSC Code | 85151701 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xi | |||||||||
| Safety Statements | 24/25 | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | GE0722000 | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29189900 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Sens. 1 |
|||||||||
| REACH Registrations | Active | |||||||||
| NFPA 704 |
|
3,4,5-Trimethoxycinnamic acid price More Price(66)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | T70408 | 3,4,5-Trimethoxycinnamic acid 97% | 90-50-6 | 25g | $58.9 | 2022-05-15 | Buy |
| Biosynth | FT71389 | 3,4,5-Trimethoxycinnamic acid | 90-50-6 | 1kg | $259.6 | 2026-06-04 | Buy |
| Biosynth | FT71389 | 3,4,5-Trimethoxycinnamic acid | 90-50-6 | 2kg | $415.36 | 2026-06-04 | Buy |
| ChemScene | CS-W012839 | 3,4,5-Trimethoxycinnamic acid ≥98% | 90-50-6 | 100g | $40 | 2026-06-04 | Buy |
| ChemScene | CS-W012839 | 3,4,5-Trimethoxycinnamic acid ≥98% | 90-50-6 | 500g | $142 | 2026-06-04 | Buy |
3,4,5-Trimethoxycinnamic acid Chemical Properties,Uses,Production
Chemical Properties
white to cream fine crystalline powder
Uses
3-(3,4,5-Trimethoxyphenyl)acrylic acid demonstrates antioxidant activity as it was detected to inhibit lipid peroxidation in rat brain homogenates.
Definition
ChEBI: A methoxycinnamic acid with three methoxy substituents at the 3-, 4- and 5-positions.
Synthesis
141-82-2
86-81-7
20329-98-0
Example IV Synthesis of 3,4,5-trimethoxycinnamic acid (by microwave radiation method): in a 100 mL Erlenmeyer flask, a mixture of 3,4,5-trimethoxybenzaldehyde (5.0 g, 0.025 mol) and malonic acid (5.30 g, 0.050 mol) was added, followed by piperidine (4-8 mL) and acetic acid (25-35 mL). The flask was fitted with a loose funnel at the top and the mixture was shaken well and placed in a microwave oven and microwaved in batches for 4-8 min. Upon completion of the reaction, the cooled mixture was poured into ice-cold water and acidified with 5% HCl solution. The precipitated yellow solid was collected by filtration and recrystallized by aqueous ethanol to give 3,4,5-trimethoxycinnamic acid in 88% yield; the melting point was 127 °C (literature value 126-128 °C). The spectral data of the product were consistent with those reported in the literature: 1H NMR (CDCl3) δ 7.73 (1H, d, J = 16.0 Hz, -CH=CH-COOH), 6.78 (2H, s, H-2 and H-6), 6.38 (1H, d, J = 16.0 Hz, CH=CH-COOH), 3.91 (9H, s, 3-OCH3, 4- OCH3, 5-OCH3); 13C NMR: δ 172.6 (COOH), 153.8 (C-3 and C-5), 147.4 (C-4), 140.8 (CH=CH-COOH), 129.8 (C-1), 116.8 (CH=CH-COOH), 105.8 (C-2 and C-6), 61.4 (4- OCH3), 56.5 (3-OCH3 and 5-OCH3).
target
5-HT Receptor | ERK | GABA Receptor | HIF-2
References
[1] MedChemComm, 2017, vol. 8, # 4, p. 755 - 766
[2] European Journal of Medicinal Chemistry, 2015, vol. 95, p. 473 - 482
[3] Medicinal Chemistry Research, 2016, vol. 25, # 6, p. 1074 - 1086
[4] Chemistry Letters, 2003, vol. 32, # 12, p. 1186 - 1187
[5] Patent: US2004/118673, 2004, A1. Location in patent: Page 7
3,4,5-Trimethoxycinnamic acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Chuanghai Biotechnology Co., Ltd | +8615350571055 | Sibel@chuanghaibio.com | China | 8738 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-86-13131129325 +8613131129325 | sales1@chuanghaibio.com | China | 5220 | 58 |
| airuikechemical co., ltd. | +86-18353166132 | sales02@airuikechemical.com | China | 983 | 58 |
| Shandong Deshang Chemical Co., Ltd. | +86-0531-8875-2665 +8613153039501 | info@deshangchem.com | China | 661 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29812 | 58 |
| Chengdu GLP biotechnology Co Ltd | 028-87075086 13350802083 | scglp@glp-china.com | CHINA | 1824 | 58 |
| Jinan Finer Chemical Co., Ltd | +86-531-88989536 +86-15508631887 | sales@finerchem.com | China | 2950 | 58 |
| Shandong chuangyingchemical Co., Ltd. | 18853181302 | sale@chuangyingchem.com | CHINA | 5906 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
View Lastest Price from 3,4,5-Trimethoxycinnamic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-05-28 | 3,4,5-Trimethoxycinnamic Acid
90-50-6
|
$2.00-5.00 | 1KG | 99% | 10000kg | Hebei Chuanghai Biotechnology Co,.LTD | |
 |
2026-03-20 | 3,4,5-Trimethoxycinnamic acid
90-50-6
|
$10.00 | 1KG | 99% | 10 mt | Hebei Chuanghai Biotechnology Co., Ltd | |
 |
2025-12-12 | 3,4,5-Trimethoxycinnamic acid
90-50-6
|
$1.00 | 1KG | 99% | 50 tons | Shaanxi Dideu Medichem Co. Ltd |
-
- 3,4,5-Trimethoxycinnamic Acid
90-50-6
- $2.00-5.00
- 99%
- Hebei Chuanghai Biotechnology Co,.LTD
-
- 3,4,5-Trimethoxycinnamic acid
90-50-6
- $10.00
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- 3,4,5-Trimethoxycinnamic acid
90-50-6
- $1.00
- 99%
- Shaanxi Dideu Medichem Co. Ltd
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