Propanoic acid, 2,2-diMethyl-3-oxo-, Methyl ester
- CAS No.
- 13865-20-8
- Chemical Name:
- Propanoic acid, 2,2-diMethyl-3-oxo-, Methyl ester
- Synonyms
- Methyl 2,2-diMethyl-3-oxopropanoate;EOS-61586;ropanoic acid, 2,2-diMethyl-3-oxo-, Methyl ester;Propanoic acid, 2,2-diMethyl-3-oxo-, Methyl ester
- CBNumber:
- CB72614701
- Molecular Formula:
- C6H10O3
- Molecular Weight:
- 130.14
- MDL Number:
- MFCD00082184
- MOL File:
- 13865-20-8.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| Methyl 2,2-dimethyl-3-oxopropanoate | TRC-M335178-50MG | 50mg | $223 |
| Methyl 2,2-dimethyl-3-oxopropanoate | TRC-M335178-10MG | 10mg | $66 |
| Methyl 2,2-dimethyl-3-oxopropanoate | TRC-M335178-100MG | 100mg | $339 |
| methyl 2,2-dimethyl-3-oxopropanoate | NAA86520 | 2.5g | $383.5 |
| Methyl 2,2-dimethyl-3-oxopropanoate | 121367 | 250.00mg | $46 |
| More product size | |||
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS02 |
|---|---|
| Signal word | Warning |
| Hazard statements | H335-H315-H226-H319 |
| Precautionary statements | P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P |
Propanoic acid, 2,2-diMethyl-3-oxo-, Methyl ester price More Price(52)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | TRC-M335178-50MG | Methyl 2,2-dimethyl-3-oxopropanoate | 13865-20-8 | 50mg | $223 | 2026-06-03 | Buy |
| TRC | TRC-M335178-10MG | Methyl 2,2-dimethyl-3-oxopropanoate | 13865-20-8 | 10mg | $66 | 2026-06-03 | Buy |
| TRC | TRC-M335178-100MG | Methyl 2,2-dimethyl-3-oxopropanoate | 13865-20-8 | 100mg | $339 | 2026-06-03 | Buy |
| Biosynth | NAA86520 | methyl 2,2-dimethyl-3-oxopropanoate | 13865-20-8 | 2.5g | $383.5 | 2026-06-04 | Buy |
| Matrix Scientific | 121367 | Methyl 2,2-dimethyl-3-oxopropanoate | 13865-20-8 | 250.00mg | $46 | 2026-05-18 | Buy |
Propanoic acid, 2,2-diMethyl-3-oxo-, Methyl ester Chemical Properties,Uses,Production
Synthesis
14002-80-3
13865-20-8
The general procedure for the synthesis of methyl 2,2-dimethyl-3-oxopropionate from methyl hydroxytrimethylacetate was as follows: first, the first intermediate compound, methyl 3-[6-chloro-2-(2,2-dimethyl-propionylamino)-pyridin-3-yl]-3-hydroxy-2,2-dimethyl-propionate, was prepared. This was done as follows: to a stirred solution of oxalyl chloride (11.0 g, 87.0 mmol) in dichloromethane (180 mL) was slowly added a solution of DMSO (12.9 mL, 182 mmol) in dichloromethane (40 mL) at -60 °C. The resulting solution was stirred for 5 minutes and then a dichloromethane (10 mL) solution of methyl 2,2-dimethyl-3-hydroxypropionate (10.0 g, 75.6 mmol) was added dropwise over 10 minutes. The cloudy mixture was continued to be stirred for 15 minutes, followed by the dropwise addition of triethylamine (52 mL, 380 mmol) and keeping the reaction temperature at -50°C or lower. After stirring for 5 minutes, the mixture was slowly warmed to room temperature. Next, water (200 mL) was added for quenching. The organic and aqueous layers were separated and the aqueous layer was extracted with dichloromethane (2 x 100 mL). The combined organic layers were washed sequentially with 1 M HCl (100 mL), water (100 mL), saturated NaHCO3 solution (100 mL), water (100 mL) and brine (100 mL), then dried with Na2SO4, filtered and concentrated. Most of the solvent was removed under vacuum and only a small amount of dichloromethane was retained to minimize loss of volatile products. The crude product was purified by vacuum distillation to afford the target product methyl 2,2-dimethyl-3-oxopropionate (8.1 g, 83% yield, boiling point 89 °C, pressure about 80 mmHg). The 1H NMR (CDCl3) data of the product were as follows: δ 9.67 (s, 1H), 3.76 (s, 3H), 1.36 (s, 6H).
References
[1] Patent: WO2017/68089, 2017, A2. Location in patent: Page/Page column 240
[2] Chemistry - A European Journal, 1999, vol. 5, # 1, p. 121 - 161
[3] Patent: WO2012/119559, 2012, A1. Location in patent: Page/Page column 105-106
[4] Tetrahedron Asymmetry, 2003, vol. 14, # 21, p. 3371 - 3378
[5] Patent: US2005/43309, 2005, A1. Location in patent: Page/Page column 78
Propanoic acid, 2,2-diMethyl-3-oxo-, Methyl ester Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Nanjing jinheyou Trading Co., Ltd. | 15705188088 | admin@jheyou.com | CHINA | 1268 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 | market18@leapchem.com | China | 43333 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131956 | 58 |
| Jia Xing Isenchem Co.,Ltd | 0573-85285100 18627885956 | isenchem@163.com | China | 9361 | 66 |
| Nanjing JinruiJiuAn Biotechnology Co., Ltd. | 025-58196018 800028039 | sales@fartop.net | China | 2229 | 55 |
| Shanghai Leto Pharmatech Co.,Ltd. | 86-021-5821 5861; 18016401466 | sales@letopharm.com | China | 235 | 58 |
| Cool Pharm, Ltd | 021-60455363 18019463053 | sales@coolpharm.com | China | 8455 | 58 |
| DebyeTec.com Inc. | 18086626237 18086626237 | 2693528373@qq.com | China | 2937 | 56 |
View Lastest Price from Propanoic acid, 2,2-diMethyl-3-oxo-, Methyl ester manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2019-11-19 | Propanoic acid, 2,2-diMethyl-3-oxo-, Methyl ester
13865-20-8
|
1g | 95%min | 20kg/month | Nanjing jinheyou Trading Co., Ltd. |
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- Propanoic acid, 2,2-diMethyl-3-oxo-, Methyl ester
13865-20-8
- $0.00
- 95%min
- Nanjing jinheyou Trading Co., Ltd.
