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ChemicalBook >> CAS DataBase List >>7-Methyl-5-[(3-piperazin-1-ylMethyl)-1,2,4-oxadiazol-5-yl-]-2-[4-(trifluoroMethoxy)benzyl]-2,3-dihydro-1H-isoindol-1-one Methanesulphonate

7-Methyl-5-[(3-piperazin-1-ylMethyl)-1,2,4-oxadiazol-5-yl-]-2-[4-(trifluoroMethoxy)benzyl]-2,3-dihydro-1H-isoindol-1-one Methanesulphonate

CAS No.
802904-66-1
Chemical Name:
7-Methyl-5-[(3-piperazin-1-ylMethyl)-1,2,4-oxadiazol-5-yl-]-2-[4-(trifluoroMethoxy)benzyl]-2,3-dihydro-1H-isoindol-1-one Methanesulphonate
Synonyms
CS-1509;AZD1981;AZD1981, >=98%;AZD-1981;AZD 1981;Leuco-dcf diacetate;AZD1981, 10 mM in DMSO;7'-Dichlorofluorescein diacetate;2-[4-acetamido-3-(4-chlorophenyl)sulfanyl-2-methylindol-1-yl]acetic acid;2-(4-acetamido-3-(4-chlorophenylthio)-2-methyl-1H-indol-1-yl)acetic acid;4-(Acetylamino)-3-[(4-chlorophenyl)thio]-2-methyl-1H-indole-1-acetic acid
CBNumber:
CB72657113
Molecular Formula:
C19H17ClN2O3S
Molecular Weight:
388.87
MDL Number:
MFCD26936340
MOL File:
802904-66-1.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-14 16:49:18
Product description Number Pack Size Price
AZD 1981 ≥98% 20763 5mg $53
AZD 1981 ≥98% 20763 10mg $80
AZD 1981 ≥98% 20763 25mg $132
AZD 1981 ≥98% 20763 50mg $238
AZD 1981 ≥98% 20763 1mg $32
More product size

7-Methyl-5-[(3-piperazin-1-ylMethyl)-1,2,4-oxadiazol-5-yl-]-2-[4-(trifluoroMethoxy)benzyl]-2,3-dihydro-1H-isoindol-1-one Methanesulphonate Properties

Boiling point 676.8±55.0 °C(Predicted)
Density 1.37±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility insoluble in H2O; insoluble in EtOH; ≥19.8 mg/mL in DMSO
form solid
pka 4.06±0.10(Predicted)
color White to gray
FDA UNII 2AD53WQ2CX

SAFETY

Risk and Safety Statements

7-Methyl-5-[(3-piperazin-1-ylMethyl)-1,2,4-oxadiazol-5-yl-]-2-[4-(trifluoroMethoxy)benzyl]-2,3-dihydro-1H-isoindol-1-one Methanesulphonate price More Price(51)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 20763 AZD 1981 ≥98% 802904-66-1 5mg $53 2026-04-30 Buy
Cayman Chemical 20763 AZD 1981 ≥98% 802904-66-1 10mg $80 2026-04-30 Buy
Cayman Chemical 20763 AZD 1981 ≥98% 802904-66-1 25mg $132 2026-04-30 Buy
Cayman Chemical 20763 AZD 1981 ≥98% 802904-66-1 50mg $238 2026-04-30 Buy
Cayman Chemical 20763 AZD 1981 ≥98% 802904-66-1 1mg $32 2024-03-01 Buy
Product number Packaging Price Buy
20763 5mg $53 Buy
20763 10mg $80 Buy
20763 25mg $132 Buy
20763 50mg $238 Buy
20763 1mg $32 Buy

7-Methyl-5-[(3-piperazin-1-ylMethyl)-1,2,4-oxadiazol-5-yl-]-2-[4-(trifluoroMethoxy)benzyl]-2,3-dihydro-1H-isoindol-1-one Methanesulphonate Chemical Properties,Uses,Production

Uses

AZD 1981 is an orally available selective DP2 antagonist in the treatment of asthma.

Biological Activity

azd1981 is a selective, orally bioavailable and potent antagonist of the chemoattractant receptor-homologous expressed on th2 lymphocytes receptor (crth2 or dp2) with an ic50 value of 4 nm [1].azd1981 has shown to inhibit eosinophil migration with a pic50 value of 7.6±0.1. azd1981 could block chemotaxis of dp2+ t-cell lines with a pic50 value of 7.5±0.1. azd1981 has been demonstrated to inhibit pgd2 binding to mouse, rat, rabbit, dog, guinea pig and human dp2. azd1981 could inhibit shape change induced by dp2 in dog and guinea pig granulocytes as well as in human eosinophils and basophils in blood [2].

IC 50

DP

References

[1] luker t1, bonnert r, brough s, cook ar, dickinson mr, dougall i, logan c, mohammed rt, paine s, sanganee hj, sargent c, schmidt ja,teague s, thom s. substituted indole-1-acetic acids as potent and selective crth2 antagonists-discovery of azd1981. bioorg med chem lett. 2011 nov 1;21(21):6288-92.
[2] schmidt ja1, bell fm, akam e, marshall c, dainty ia, heinemann a, dougall ig, bonnert rv, sargent ca. biochemical and pharmacological characterization of azd1981, an orally available selective dp2 antagonist in clinical development for asthma. br j pharmacol. 2013 apr;168(7):1626-38.

7-Methyl-5-[(3-piperazin-1-ylMethyl)-1,2,4-oxadiazol-5-yl-]-2-[4-(trifluoroMethoxy)benzyl]-2,3-dihydro-1H-isoindol-1-one Methanesulphonate Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 113)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32998 60
career henan chemical co 		+86-0371-86658258 factory@coreychem.com China 29780 58
TargetMol Chemicals Inc. 		+1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250 1059@dideu.com China 29096 58
BOC Sciences 		16314854226; +8616314854226 inquiry@bocsci.com United States 19852 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 sales@sarms4muscle.com China 10378 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6378 58
HANGZHOU LEAP CHEM CO., LTD. 		+86-571-87711850 +8619957148339 market18@leapchem.com China 24569 58
TargetMol Chemicals Inc. 		+1-781-999-5354; support@targetmol.com United States 38999 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		13417589054 trendseenbio@gmail.com China 11674 58

View Lastest Price from 7-Methyl-5-[(3-piperazin-1-ylMethyl)-1,2,4-oxadiazol-5-yl-]-2-[4-(trifluoroMethoxy)benzyl]-2,3-dihydro-1H-isoindol-1-one Methanesulphonate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
AZD1981 pictures 2026-07-14 AZD1981
802904-66-1
 $47.00-192.00 99.67% 10g TargetMol Chemicals Inc.
2-[4-acetamido-3-(4-chlorophenyl)sulfanyl-2-methylindol-1-yl]acetic acid pictures 2020-01-02 2-[4-acetamido-3-(4-chlorophenyl)sulfanyl-2-methylindol-1-yl]acetic acid
802904-66-1
 $1.00 1KG Min98% HPLC Career Henan Chemical Co
  • AZD1981 pictures
  • AZD1981
    802904-66-1
  • $47.00-192.00
  • 99.67%
  • TargetMol Chemicals Inc.

7-Methyl-5-[(3-piperazin-1-ylMethyl)-1,2,4-oxadiazol-5-yl-]-2-[4-(trifluoroMethoxy)benzyl]-2,3-dihydro-1H-isoindol-1-one Methanesulphonate Spectrum

802904-66-1(7-Methyl-5-[(3-piperazin-1-ylMethyl)-1,2,4-oxadiazol-5-yl-]-2-[4-(trifluoroMethoxy)benzyl]-2,3-dihydro-1H-isoindol-1-one Methanesulphonate)Related Search:

7-Methyl-5-[(3-piperazin-1-ylMethyl)-1,2,4-oxadiazol-5-yl-]-2-[4-(trifluoroMethoxy)benzyl]-2,3-dihydro-1H-isoindol-1-one Methanesulphonate AZD1981 1H-Indole-1-acetic acid, 4-(acetylamino)-3-[(4-chlorophenyl)thio]-2-methyl- AZD1981, >=98% 4-(Acetylamino)-3-[(4-chlorophenyl)thio]-2-methyl-1H-indole-1-acetic acid AZD-1981;AZD 1981 CS-1509 2-[4-acetamido-3-(4-chlorophenyl)sulfanyl-2-methylindol-1-yl]acetic acid 7-Methyl-5-[(3-piperazin-1-ylMethyl)-1,2,4-oxadiazol-5-yl-]-2-[4-(trifluoroMethoxy)benzyl]-2,3-dihydro-1H-isoindol-1-one Methanesulphonate USP/EP/BP 7'-Dichlorofluorescein diacetate Leuco-dcf diacetate 2-(4-acetamido-3-(4-chlorophenylthio)-2-methyl-1H-indol-1-yl)acetic acid AZD1981, 10 mM in DMSO 802904-66-1 Inhibitors
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