BI 6015
- CAS No.
- 93987-29-2
- Chemical Name:
- BI 6015
- Synonyms
- B16015;BI 6015;BI6015 ，E0401;BI-6015, 10 mM in DMSO;HNF4 Antagonist, BI6015;2-methyl-1-(2-methyl-5-nitrophenyl)sulfonylbenzimidazole;2-Methyl-1-[(2-methyl-5-nitrophenyl)sulfonyl]-1H-benzimidazole;2-Methyl-1-(2-methyl-5-nitrophenylsulfonyl)-1H-benzo[d]imidazole;1H-Benzimidazole, 2-methyl-1-[(2-methyl-5-nitrophenyl)sulfonyl]-;inhibit,promoter,HNF4α,factor,hepatocyte,Inhibitor,diabetes,insulin,BI-6015,BI6015,nuclear,cancer,BI 6015
- CBNumber:
- CB72695661
- Molecular Formula:
- C15H13N3O4S
- Molecular Weight:
- 331.35
- MDL Number:
- MFCD04406654
- MOL File:
- 93987-29-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| HNF4 Antagonist, BI6015 - CAS 93987-29-2 - Calbiochem The HNF4 Antagonist, BI6, also referenced under CAS 93987-29-2, controls the biological activity of HNF4. |
375240 | 25mg | $242 |
| BI-6015 ≥95% | 12032 | 5mg | $53 |
| BI-6015 ≥95% | 12032 | 10mg | $95 |
| BI-6015 ≥95% | 12032 | 25mg | $212 |
| BI-6015 ≥95% | 12032 | 50mg | $396 |
| More product size | |||
| Boiling point | 570.6±60.0 °C(Predicted) |
|---|---|
| Density | 1.45±0.1 g/cm3(Predicted) |
| storage temp. | +2C to +8C |
| solubility | Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 10 mg/ml). |
| form | Beige powder |
| pka | 0.88±0.10(Predicted) |
| color | Tan |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months. |
| InChI | InChI=1S/C15H13N3O4S/c1-10-7-8-12(18(19)20)9-15(10)23(21,22)17-11(2)16-13-5-3-4-6-14(13)17/h3-9H,1-2H3 |
| InChIKey | ILVCPQPMRPHZSG-UHFFFAOYSA-N |
| SMILES | C1(C)N(S(C2=CC([N+]([O-])=O)=CC=C2C)(=O)=O)C2=CC=CC=C2N=1 |
| UNSPSC Code | 12352200 |
| NACRES | NA.32 |
BI 6015 price More Price(55)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 375240 | HNF4 Antagonist, BI6015 - CAS 93987-29-2 - Calbiochem The HNF4 Antagonist, BI6, also referenced under CAS 93987-29-2, controls the biological activity of HNF4. |
93987-29-2 | 25mg | $242 | 2026-04-30 | Buy |
| Cayman Chemical | 12032 | BI-6015 ≥95% | 93987-29-2 | 5mg | $53 | 2026-04-30 | Buy |
| Cayman Chemical | 12032 | BI-6015 ≥95% | 93987-29-2 | 10mg | $95 | 2026-04-30 | Buy |
| Cayman Chemical | 12032 | BI-6015 ≥95% | 93987-29-2 | 25mg | $212 | 2026-04-30 | Buy |
| Cayman Chemical | 12032 | BI-6015 ≥95% | 93987-29-2 | 50mg | $396 | 2026-04-30 | Buy |
BI 6015 Chemical Properties,Uses,Production
Description
BI-6015 (93987-29-2) is a hepatocyte nuclear factor 4α (HNF4α) antagonist. HNF4α is a central regulator of gene expression in cell types that play a central role in metabolic homeostasis.1 BI-6015 binds to HNF4α with high affinity and modulates the expression of known target genes. It was shown to be selectively cytotoxic to cancer cell lines in vitro and in vivo however in vivo potency was limited by suboptimal pharmacokinetics.2 BI-6015 represents the first small molecule tool for pharmacologic modulation of HNF4α activity.2 Cell permeable.
Uses
BI 6015 is a known HNF4α antagonist that represses the expression of known HNF4α target genes. Studies have shown that BI6015 are also capable of exhibiting selective cytotoxic activities against numerous tumor cell lines.
in vivo
BI-6015 (10-30 mg/kg; i.p. once daily for 5 days) induces loss of HNF4α expression and hepatic steatosis in mice[1].
BI-6015 (10-30 mg/kg; i.p. daily or every other day for 20-57 days) induces apoptosis in a human hepatocellular carcinoma mouse model[1].
storage
Store at -20°C
References
[1] H WANG. Hepatocyte nuclear factor 4alpha regulates the expression of pancreatic beta -cell genes implicated in glucose metabolism and nutrient-induced insulin secretion.[J]. The Journal of Biological Chemistry, 2000, 275 46: 35953-35959. DOI:10.1074/jbc.m006612200
[2] ALICE KISELYUK. HNF4α antagonists discovered by a high-throughput screen for modulators of the human insulin promoter.[J]. Chemistry & biology, 2012: 806-818. DOI:10.1016/j.chembiol.2012.05.014
BI 6015 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32468 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +86-13203830695 | laboratory@coreychem.com | China | 30224 | 58 |
| BOC Sciences | 16314854226; +8616314854226 | inquiry@bocsci.com | United States | 19853 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +86-18327326525 | masar@topule.com | China | 8467 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Suzhou Zhixin Biotechnology Co., Ltd. | 0512-65118909 18100677375 | sales@szzxbio.com | China | 1045 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Guangzhou Isun Pharmaceutical Co., Ltd | 020-39119399 18927568969 | isunpharm@qq.com | China | 4784 | 55 |
| Shanghai TaoSu Biochemical Technology Co., Ltd. | 021-33632979 | info@tsbiochem.com | China | 8065 | 58 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4874 | 55 |
