1-Benzyl-3,5-diMethylpiperidin-4-one
- CAS No.
- 836-21-5
- Chemical Name:
- 1-Benzyl-3,5-diMethylpiperidin-4-one
- Synonyms
- 1-Benzyl-3,5-dimethyl-4-piperidone;1-Benzyl-3,5-diMethylpiperidin-4-one;4-Piperidinone, 3,5-dimethyl-1-(phenylmethyl)-;1-Benzyl-3,5-dimethylpiperidin-4-one(cis:trans=85:15)
- CBNumber:
- CB72735819
- Molecular Formula:
- C14H19NO
- Molecular Weight:
- 217.31
- MDL Number:
- MFCD14583139
- MOL File:
- 836-21-5.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 1-Benzyl-3,5-dimethylpiperidin-4-one 98% | AS43316-rac | 1g | $660 |
| 1-Benzyl-3,5-dimethylpiperidin-4-one 95% | AA004TQ3 | 250mg | $248 |
| 1-Benzyl-3,5-dimethylpiperidin-4-one 95% | AA004TQ3 | 1g | $522 |
| 1-benzyl-3,5-dimethylpiperidin-4-one 97% | Q65184 | 250MG | $215 |
| 1-benzyl-3,5-dimethylpiperidin-4-one 97% | Q65184 | 1G | $475 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
1-Benzyl-3,5-diMethylpiperidin-4-one price More Price(16)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Activate Scientific | AS43316-rac | 1-Benzyl-3,5-dimethylpiperidin-4-one 98% | 836-21-5 | 1g | $660 | 2026-06-04 | Buy |
| aablocks | AA004TQ3 | 1-Benzyl-3,5-dimethylpiperidin-4-one 95% | 836-21-5 | 250mg | $248 | 2026-05-28 | Buy |
| aablocks | AA004TQ3 | 1-Benzyl-3,5-dimethylpiperidin-4-one 95% | 836-21-5 | 1g | $522 | 2026-05-28 | Buy |
| ACHEMBLOCK | Q65184 | 1-benzyl-3,5-dimethylpiperidin-4-one 97% | 836-21-5 | 250MG | $215 | 2026-05-27 | Buy |
| ACHEMBLOCK | Q65184 | 1-benzyl-3,5-dimethylpiperidin-4-one 97% | 836-21-5 | 1G | $475 | 2026-05-27 | Buy |
1-Benzyl-3,5-diMethylpiperidin-4-one Chemical Properties,Uses,Production
Synthesis
34737-89-8
74-88-4
836-21-5
To a solution of 1-benzyl-3-methyl-piperidin-4-one (4.06 g, 20 mmol) in anhydrous THF (20 mL) at -78 °C was slowly added lithium hexamethyldisilaminate (21 mL, 21 mmol, 1.0 M THF solution). After stirring at -78 °C for 30 min, a solution of THF (5 mL) in iodomethane (1.31 mL, 21 mmol) was added dropwise to the reaction mixture. The reaction solution was gradually warmed to 25 °C and stirring was continued for 2 hours. Upon completion of the reaction, the reaction was quenched with water. The aqueous layer was extracted with dichloromethane (CH2Cl2) and the organic phases were combined, washed with saturated brine and dried over anhydrous magnesium sulfate (MgSO4). After filtration, the filtrate was concentrated under reduced pressure to give the crude product. The crude product was purified by fast column chromatography (eluent: hexane/ethyl acetate) to afford 1.37 g (31.5% yield) of 1-benzyl-3,5-dimethylpiperidin-4-one. The crude product 1-benzyl-3,5-dimethylpiperidin-4-ylamine (5) was prepared as a mixture of diastereoisomers with reference to the method of Scheme 1-1. LCMS assay showed the target molecular weight: 219 (M + H)+. The product could be used in the next reaction without further purification.
References
[1] Patent: WO2004/58736, 2004, A1. Location in patent: Page 26; 29
[2] Patent: WO2004/58709, 2004, A1. Location in patent: Page 31; 34
[3] Patent: US2002/169155, 2002, A1
[4] Patent: US2005/70549, 2005, A1
[5] Patent: US2016/31908, 2016, A1. Location in patent: Paragraph 1165; 1166; 1167
1-Benzyl-3,5-diMethylpiperidin-4-one Preparation Products And Raw materials
Raw materials
Preparation Products
1-Benzyl-3,5-diMethylpiperidin-4-one Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Aladdin Scientific | tp@aladdinsci.com | United States | 52906 | 58 | |
| Suzhou ARTK Medchem Co., Ltd. | +86-18168183658 | sales1@artkmedchem.com | China | 39007 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Mashilabs (Shanghai) Co.,Ltd. | 19916721580 | mafarm@126.com | China | 4538 | 58 |
| Cool Pharm, Ltd | 021-60455363 18019463053 | sales@coolpharm.com | China | 8455 | 58 |
| Shanghai DongYang Biotechnology Co., Ltd. | 18657622632 | chemsharker@126.com | China | 371 | 55 |
| Shanghai Chaolan Chemical Technology Center | QQ：65489617 13301690235 | Sales@ATKchemical.com | China | 9647 | 58 |
| Nanjing KaiMubo Pharmaceutical Co., Ltd. | 025-66162170 | China | 7180 | 55 | |
| Combiphos (Shanghai) Biological Technology Co., Ltd. | 021-65232103 17602124823 | combiphos@vip.qq.com | China | 30000 | 58 |
| Combiphos (Shanghai) Biological Technology Co., Ltd. | 021-65232103 17602124823 | combiphos@vip.qq.com | China | 29993 | 58 |
